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3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Word Map on EC 3.4.22.1

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.1 cathepsin B

Molecular Weight

Molecular Weight on EC 3.4.22.1 - cathepsin B

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
13600
Dorytheuthis bleekeri
-
gel filtration
15000
-
x * 15000, form I, SDS-PAGE, x * 20000, form II, SDS-PAGE, x * 30000, form III, SDS-PAGE
20000
-
x * 15000, form I, SDS-PAGE, x * 20000, form II, SDS-PAGE, x * 30000, form III, SDS-PAGE
22000
-
gel filtration
22500
-
sedimentation equilibrium centrifugation
23000
23000 - 25000
-
gel filtration, SDS-PAGE
23400
-
x * 31000, single-chain form, x * 23400 or x * 25000, heavy chain of double chain form, SDS-PAGE
24000
24000 - 25000
mature protein, SDS-PAGE
24000 - 31000
-
isoenzyme I, gel filtration, SDS-PAGE
24250
-
sedimentation equilibrium centrifugation
24500
25000
25250
-
gel filtration
25500 - 27000
-
gel filtration, SDS-PAGE
26000
26000 - 28000
-
gel filtration, SDS-PAGE
26900
-
x * 26900, calculated from amino acid sequence
27000
27000 - 27800
-
gel filtration, SDS-PAGE
27000 - 29000
-
gel filtration, SDS-PAGE
27000 - 33000
-
isoenzyme II, gel filtration, SDS-PAGE
27300 - 28300
-
gel filtration, SDS-PAGE
27500
-
gel filtration, SDS-PAGE
28000
28500
mature protein, calculated from amino acid sequence
28790
-
derived from cDNA sequence
28800
29000
29000 - 30000
29220
mature protein, calculated from amino acid sequence
30000
31000
32000
-
x * 37000, procathepsin B, x * 32000, intermediate cathepsin B, x * 30000, mature enzyme, SDS-PAGE
32400
-
x * 62200, preproenzyme, x * 32400, mature enzyme, calculated from amino acid sequence
33000
34000
36000
36191
calculated from sequence
36250
x * 36250, calculated from amino acid sequence
36310
calculated from cDNA
36400
-
calculated from sequence
36500
zymogen protein, calculated from amino acid sequence
36800
calculated from sequence
36900
proenzyme, SDS-PAGE
37000
37120
pro-protein, calculated from amino acid sequence
38000
calculated from cDNA
38400
calculated from cDNA
38550
calculation from sequence, the deduced CpCathB protein is encoded as a preproenzyme with 347 amino acid residues and predicted molecular weight of 38550
38700
full length protein, calculated from amino acid sequence
38980
prepro-protein, calculated from amino acid sequence
39000
-
x * 39000, enzyme precursor form, SDS-PAGE, x * 30000-31000, intermediate single-chain enzyme form, SDS-PAGE, x* 24000-25000, mature double-chain enzyme form, SDS-PAGE
40000
-
x * 40000, SDS-PAGE
400000
gel filtration
40850
-
x * 40850, calculated from amino acid sequence
42000
SDS-PAGE, procathepsin B
43000
43000 - 46000
proenzyme, SDS-PAGE
55000
62200
-
x * 62200, preproenzyme, x * 32400, mature enzyme, calculated from amino acid sequence
63000
LC-ESI mass spectrometry
68000
-
filtration, SDS-PAGE