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3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Word Map on EC 3.4.22.1

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.1 cathepsin B

Activating Compound

Activating Compound on EC 3.4.22.1 - cathepsin B

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,3-Dimercaptopropanol
-
-
2-mercaptoethanol
2-mercaptoethylamine
-
-
asparaginyl endopeptidase from Schistosoma mansoni
-
-
cysteamine
cysteine
dithiothreitol
emodin
-
i.e. 1,3,8-trihydroxy-6-methylanthraquinone, emodin at apoptosis-inducing concentrations causes expression and activation of cathepsin B protein
glutathione
heparin
-
at pH 8.0, heparin increases the half-life of wild type enzyme from 84 sec to 433 sec
imatinib
-
activates cathepsin B and mediates its redistribution to the cytoplasm
interferon-gamma
-
-
-
interleukin-6
-
IL-6, in the presence of soluble form of IL-6 receptor, sIL-6R, enhances cathepsin B expression and activity via the Cav-1-JNK-AP-1 pathway in fibroblasts of the gingiva
Kainic acid
-
1.25-5 nM
L-cysteine
-
cathepsin B is activated at 22°C for 5 min in 100 mM sodium acetate, 1 mM DTT, 2 mM EDTA, 4 mM cysteine, pH 5.5
lipopolysaccharide
-
activates a Cat-B-dependent programmed death response in endothelial cells that is independent of both myeloid differentiation factor 88 and Toll-like receptor-associated interferon-inducing factor, is blocked by both Fas-associated death domain protein and phosphatidylinositol 3 kinase. Activates both caspase- and Cat B-dependent death pathways in presence of phosphatidylinositol 3 kinase inhibitor LY294002 or the inflammatory cytokine interferon-gamma
pepsin A
-
-
reduced glutathione
-
the presence of reduced glutathione at concentrations of more than 10 mM significantly increases activity at pH 4.0
thioglycerol
thiol compounds
tumor necrosis factor-related apoptosis inducing ligand
-
an increase in the cellular amount of active 31 kDa cathepsin B is observed after tumor necrosis factor-related apoptosis inducing ligand treatment (100 ng/ml)
-
additional information
-