Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2,3-Dimercaptopropanol
-
-
asparaginyl endopeptidase from Schistosoma mansoni
-
-
emodin
-
i.e. 1,3,8-trihydroxy-6-methylanthraquinone, emodin at apoptosis-inducing concentrations causes expression and activation of cathepsin B protein
heparin
-
at pH 8.0, heparin increases the half-life of wild type enzyme from 84 sec to 433 sec
imatinib
-
activates cathepsin B and mediates its redistribution to the cytoplasm
interleukin-6
-
IL-6, in the presence of soluble form of IL-6 receptor, sIL-6R, enhances cathepsin B expression and activity via the Cav-1-JNK-AP-1 pathway in fibroblasts of the gingiva
L-cysteine
-
cathepsin B is activated at 22°C for 5 min in 100 mM sodium acetate, 1 mM DTT, 2 mM EDTA, 4 mM cysteine, pH 5.5
lipopolysaccharide
-
activates a Cat-B-dependent programmed death response in endothelial cells that is independent of both myeloid differentiation factor 88 and Toll-like receptor-associated interferon-inducing factor, is blocked by both Fas-associated death domain protein and phosphatidylinositol 3 kinase. Activates both caspase- and Cat B-dependent death pathways in presence of phosphatidylinositol 3 kinase inhibitor LY294002 or the inflammatory cytokine interferon-gamma
reduced glutathione
-
the presence of reduced glutathione at concentrations of more than 10 mM significantly increases activity at pH 4.0
tumor necrosis factor-related apoptosis inducing ligand
-
an increase in the cellular amount of active 31 kDa cathepsin B is observed after tumor necrosis factor-related apoptosis inducing ligand treatment (100 ng/ml)
-
2-mercaptoethanol
-
activates
2-mercaptoethanol
-
activates
2-mercaptoethanol
-
activates
2-mercaptoethanol
-
activates
2-mercaptoethanol
-
activates
2-mercaptoethanol
-
activates
2-mercaptoethanol
-
activates
2-mercaptoethanol
-
activates
2-mercaptoethanol
-
activates
2-mercaptoethanol
2.0 mM, 1.75fold activation
cysteamine
-
activates
cysteine
-
activates
dithiothreitol
-
activates
dithiothreitol
-
activates
dithiothreitol
-
required to reduce the enzyme to its catalytically active form
dithiothreitol
-
activates
dithiothreitol
-
activates
dithiothreitol
-
activates
dithiothreitol
-
activates
dithiothreitol
-
activates
dithiothreitol
-
activates
dithiothreitol
-
the presence of dithiothreitol at concentrations of more than 10 mM significantly increases activity at pH 4.0
dithiothreitol
-
activates
dithiothreitol
-
activates
EDTA
-
no effect at 0.5 mM
EDTA
-
activates in presence of thiol compound
EDTA
1.0 mM, 1.2fold activation
glutathione
-
activates
thioglycerol
-
activates
thiol compounds
-
required for full activity
thiol compounds
-
absolute requirement
thiol compounds
-
required for full activity
thiol compounds
-
required for full activity
thiol compounds
-
required for full activity
thiol compounds
-
required for full activity
thiol compounds
-
required for full activity
thiol compounds
-
required for full activity
thiol compounds
-
absolute requirement
thiol compounds
-
required for full activity
thiol compounds
-
required for full activity
additional information
3.5fold higher up-regulation of cathepsin B transcript in resistant than in the susceptible snail after Schistosoma mansoni parasite exposure
-
additional information
-
3.5fold higher up-regulation of cathepsin B transcript in resistant than in the susceptible snail after Schistosoma mansoni parasite exposure
-
additional information
soyacystatin N induces expression of CmCatB1, but not of CmCatB2
-
additional information
soyacystatin N induces expression of CmCatB1, but not of CmCatB2
-
additional information
-
soyacystatin N induces expression of CmCatB1, but not of CmCatB2
-
additional information
-
deglycosylation enhances CmCatB activity, but compromises CmCatB stability
-
additional information
serum-starvation increases cathepsin B-like activation in zebrafish follicles, not due to an increase in gene expression. No effects on cathepsin B activity by human chorionic gonadotropin and 17beta-estradiol
-
additional information
-
serum-starvation increases cathepsin B-like activation in zebrafish follicles, not due to an increase in gene expression. No effects on cathepsin B activity by human chorionic gonadotropin and 17beta-estradiol
-
additional information
-
cell treatment with attenuated bacillus Calmette-Guerin increases enzyme expression and activity
-
additional information
-
activator buffer contains 5 mM EDTA, 10 mM DTT, pH 5.2
-
additional information
-
neutrophil elastase induces expression of cathepsin B in vivo and in vitro
-
additional information
-
Porphyromonas gingivalis strain 381 or its lipopolysaccharides increases the expression of cathepsin B 3fold in oral epithelial cells, while the expression of the cathepsin B specific inhibitor cytsatin is reduced 5fold
-
additional information
-
knockdown of cellular FLICE inhibitory protein potentiates the caspase-dependent pathway but does not activate the Cat B-dependent death response. Also knockdown of either myeloid differentiation factor 88 or Toll-like receptor-associated interferon-inducing factor expression does not affect the LPS-triggered Cat B death response in Fas-associated death domain protein-deficient human umbilical vein endothelial cells
-
additional information
-
p53-dependent lysosomal destabilization and cathepsin B activation contribute for increased sensitivity of p21-deficient cells to embelin with enhanced caspase 9 and caspase 3 activation
-
additional information
-
phagocytosis of crystalline silica induces lysosomal destabilization and subsequent release of cathepsin B into the cytoplasm, leading to NALP3 activation. Release of specific proteases such as cathepsin B seems to be causally related to inflammasome activation
-
additional information
-
pharmacological or short hairpin RNA-mediated inhibition of tyrosine kinase BCR-ABL triggers lysosomal membrane permeabilization that culminates in activation and redistribution of cathepsin B into the cytoplasm of chronic myelogenous leukemia cells, in which it triggers directly BCR-ABL degradation
-
additional information
-
the autocatalytic processing of procathepsin B is triggered by proenzyme activity, overview
-
additional information
-
bafilomycin A1 induces lysosome-associated podosome-like structures and promotes degradation of extracellular gelatin
-
additional information
-
during in vivo liver fibrogenesis, caused by CCl4 administration, CtsB expression increases in hepatic stellate cells but not in hepatocytes
-
additional information
the enzyme expression is induced by virus, e.g. Scophthalmus maximus rhabdovirus, SMRV, or UV-inactivated grass carp hemorrhage virus, GCHV, by poly I:C, and lipopolysaccharide, overview. SMRV upregulation takes place predominantly in spleen, head kidney, posterior kidney, intestine, gill, and muscle
-
additional information
-
the enzyme expression is induced by virus, e.g. Scophthalmus maximus rhabdovirus, SMRV, or UV-inactivated grass carp hemorrhage virus, GCHV, by poly I:C, and lipopolysaccharide, overview. SMRV upregulation takes place predominantly in spleen, head kidney, posterior kidney, intestine, gill, and muscle
-
additional information
-
Schistosome asparaginyl endopeptidase, i.e. legumain, is not essential for cathepsin B1 activation in vivo
-