3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.1 cathepsin B

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
113	Activating Compound
1179	AA Sequence
43	Application
1	CAS Registry Number
62	Cloned(Commentary)
9	Crystallization (Commentary)
7005	Disease/ Diagnostics
31	Expression
103	General Information
7	General Stability
260	IC50 Value
957	Inhibitors
32	kcat/KM [mM/s]
177	Ki Value [mM]
223	KM Value [mM]
126	Localization
3	Metals/Ions
104	Molecular Weight [Da]
115	Natural Substrates/ Products (Substrates)
5	Organic Solvent Stability
986	Organism
60	PDB ID
120	pH Optimum
32	pH Range
21	pH Stability
5	pI Value
38	Posttranslational Modification
61	Protein Variants
74	Purification (Commentary)
5	Reaction
2	Reaction Type
299	Reference
3	Renatured (Commentary)
440	Source Tissue
56	Specific Activity [micromol/min/mg]
5	Storage Stability
617	Substrates and Products (Substrate)
47	Subunits
199	Synonyms
70	Temperature Optimum [°C]
8	Temperature Range [°C]
16	Temperature Stability [°C]
54	Turnover Number [1/s]

Temperature Range

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Temperature Range on EC 3.4.22.1 - cathepsin B

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Temperature Range Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

17 - 57

Angiostrongylus cantonensis

-

the activity is relatively stable at 17°C and 27°C, retaining about 95% and 98% activity, respectively. The relative activities at 47°C and 57°C are 31% and 13% of that at 37°C, respectively

718184

20 - 50

Cynoglossus semilaevis

G9FTP5

more than 60% of maximum activity between 20 und 50°C

717519

25 - 55

Scophthalmus maximus

Q27HX3

60% of activity maintained

733892

30 - 50

Oreochromis niloticus

A0A2U8JGA6

30°C: about 70% of maximal activity, 50°C: about 80% of maximal activity

753845

30 - 55

2 entries

35 - 45

Radopholus similis

G8Z9T0

35°C: about 70% of maximal activity, 45°C: about 25% of maximal activity

753877

45 - 60

Trachurus japonicus

A0A0P0YP15

45°C: about 45% of maximal activity, 60°C: about 45% of maximal activity

754582

30 - 55

Cyprinus carpio

-

greater activity than 50% of maximum

35024

30 - 55

Homo sapiens

-

-

36647