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3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Word Map on EC 3.4.22.1

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.1 cathepsin B

KI Value

KI Value on EC 3.4.22.1 - cathepsin B

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.181 - 0.25
(1R,2S)-2-([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)cyclohexane-1-carboxylic acid
0.000052
(5S)-5-([N-[(benzyloxy)carbonyl]-L-phenylalanyl]amino)-7-[(2,6-dimethylbenzoyl)oxy]-6-oxoheptan-1-aminium trifluoroacetate
pH 6, 37°C
0.00008
(5S)-5-([N-[(benzyloxy)carbonyl]-L-phenylalany]amino)-6-oxo-7-[(2,4,6-trimethylbenzoyl)oxy]heptan-1-aminium trifluoroacetate
pH 6, 37°C
0.019 - 0.079
(benzyl[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)acetonitrile
0.00035
(S)-18-[(S)-2-([(benzyloxy)carbonyl]amino)-3-phenylpropanamido]-1-(4-iodo-1H-1,2,3-triazol-1-yl)-12,19-dioxo-3,6,9-trioxa-13-azaicosan-20-yl 2,4,6-trimethylbenzoate
pH 6, 37°C
0.00037
(S)-20-[(S)-2-([(benzyloxy)carbonyl]amino)-3-phenylpropanamido]-1-(3-iodophenyl)-1,14,21-trioxo-5,8,11-trioxa-2,15-diazadocosan-22-yl 2,4,6-trimethylbenzoate
pH 6, 37°C
0.000181
(S)-20-[(S)-2-([(benzyloxy)carbonyl]amino)-3-phenylpropanamido]-1-(4-iodophenyl)-1,14,21-trioxo-5,8,11-trioxa-2,15-diazadocosan-22-yl 2,4,6-trimethylbenzoate
pH 6, 37°C
0.002
(S)-3-[(S)-2-([(benzyloxy)carbonyl]amino)-3-phenylpropanamido]-7-(3-iodobenzamido)-2-oxoheptyl 2,4,6-trimethylbenzoate
pH 6, 37°C
0.001
(S)-3-[(S)-2-([(benzyloxy)carbonyl]amino)-3-phenylpropanamido]-7-[6-(4-iodo-1H-1,2,3-triazol-1-yl)hexanamido]-2-oxoheptyl 2,4,6-trimethylbenzoate
pH 6, 37°C
0.126 - 0.172
([(8-hydroxy-5-nitroquinolin-7-yl)methyl](methyl)amino)acetonitrile
0.005 - 0.426
([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)acetonitrile
0.08
1,3,5-triphenyl pyrazole
pH 6, 37°C
0.0909
1,3,5-triphenyl-2-pyrazoline
pH 6, 37°C
0.034 - 0.17
1-(4-nitronaphthalen-1-yl)pyrrolidine
0.032 - 0.212
2-bromo-4-nitronaphthalen-1-amine
0.00136
2-chlorobenzohydrazide
pH 5, 37°C
0.0127
2-methoxybenzohydrazide
pH 5, 37°C
0.181 - 0.469
2-methyl-5-nitroquinolin-8-ol
0.04
3,5-diphenyl-2-pyrazoline
pH 6, 37°C
0.1205
3,5-diphenyl-4-amino-1,2,4-triazole
pH 5, 37°C
0.0032
3-(2-hydroxy-3-methylphenyl)-5-(2-hydroxy-3-methylphenyl)-4-amino-1,2,4-triazole
pH 5, 37°C
0.0149
3-(2-methylphenyl)-5-(2-methylphenyl)-4-amino-1,2,4-triazole
pH 5, 37°C
0.00095
3-(3-aminophenyl)-5-(3-aminophenyl)-4-amino-1,2,4-triazole
pH 5, 37°C
0.0385
3-(3-methylphenyl)-5-(3-methylphenyl)-4-amino-1,2,4-triazole
pH 5, 37°C
0.0024
3-(4-chlorophenyl)-5-(4-chlorophenyl)-4-amino-1,2,4-triazole
pH 5, 37°C
0.008
3-(4-methylphenyl)-5-(4-methylphenyl)-4-amino-1,2,4-triazole
pH 5, 37°C
0.00143
3-phenyl-5-(3-nitrophenyl)-4-amino-1,2,4-triazole
pH 5, 37°C
0.0048
3-phenyl-5-(4-nitrophenyl)-4-amino-1,2,4-triazole
pH 5, 37°C
0.085 - 0.289
4-(4-nitronaphthalen-1-yl)morpholine
0.003883
4-bromochalcone phenyl hydrazone
pH 6, 37°C
0.00328
4-chlorochalcone phenyl hydrazone
pH 6, 37°C
0.0019
4-hydroxybenzohydrazide
pH 5, 37°C
0.118 - 0.323
4-methoxy-3-(3-methoxypropoxy)-1-(5-nitroquinolin-8-yl)pyridin-1-ium
0.00064
4-methoxybenzohydrazide
pH 5, 37°C
0.00288
4-methoxychalcone phenyl hydrazone
pH 6, 37°C
0.00315
4-methylchalcone phenyl hydrazone
pH 6, 37°C
0.000042
4-nitrochalcone phenyl hydrazone
pH 6, 37°C
0.147 - 0.217
4-nitronaphthalen-1-amine
0.373
4-nitronaphthalen-1-ol
-
substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C
0.072 - 0.146
5,7-dinitroquinolin-8-ol
0.0526
5-(4-bromophenyl)-1,3-diphenyl pyrazole
pH 6, 37°C
0.000053
5-(4-bromophenyl)-1,3-diphenyl-2-pyrazoline
pH 6, 37°C
0.01481
5-(4-bromophenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
0.0178
5-(4-chlorophenyl)-1,3-diphenyl pyrazole
pH 6, 37°C
0.01
5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline
pH 6, 37°C
0.038
5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
0.0047
5-(4-methoxyphenyl)-1,3-diphenyl pyrazole
pH 6, 37°C
0.001311
5-(4-methoxyphenyl)-1,3-diphenyl-2-pyrazoline
pH 6, 37°C
0.07407
5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
0.007243
5-(4-methylphenyl)-1,3-diphenyl pyrazole
pH 6, 37°C
0.001365
5-(4-methylphenyl)-1,3-diphenyl-2-pyrazoline
pH 6, 37°C
0.1143
5-(4-methylphenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
0.001311
5-(4-nitrophenyl)-1,3-diphenyl pyrazole
pH 6, 37°C
0.01274
5-(4-nitrophenyl)-1,3-diphenyl-2-pyrazoline
pH 6, 37°C
0.000131
5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
0.311 - 0.364
5-nitro-7-((4-[(pyridin-3-yl)methyl]piperazin-1-yl)methyl)quinolin-8-ol
0.143 - 0.162
5-nitro-7-((4-[(pyridin-4-yl)methyl]piperazin-1-yl)methyl)quinolin-8-ol
0.047 - 0.107
5-nitro-N-[(pyridin-2-yl)methyl]quinolin-8-amine
0.203 - 0.243
7-([(2R)-2-methylpiperidin-1-yl]methyl)-5-nitroquinolin-8-ol
0.154 - 0.198
7-[(benzylamino)methyl]-5-nitroquinolin-8-ol
0.117 - 0.136
7-[(ethylamino)methyl]-5-nitroquinolin-8-ol
0.024 - 0.207
8-(4-methylpiperidin-1-yl)-5-nitroquinoline
0.155 - 0.18
8-(morpholin-4-yl)-5-nitroquinoline
0.142 - 0.214
8-hydroxy-5-nitroquinoline-2-carbonitrile
0.117 - 0.221
8-hydroxy-5-nitroquinoline-7-carboxylic acid
0.0302
ammonium 1-tribromo-1,3,2-dioxatellurolane
-
pH 6.5, 25°C
0.0127
ammonium 1-trichloro-1,3,2-dioxatellurolane
-
pH 6.5, 25°C
0.0024
Cabin-A1
-
pH 5.5, 37°C
0.29
Cabin-A2
-
pH 5.5, 37°C
0.0000876
canecystatin-1
-
in 100 mM sodium acetate pH 5.5, 2.5 mM dithiothreitol, at 37°C
-
0.00000058
canecystatin-4
-
in 100 mM sodium acetate pH 5.5, 2.5 mM dithiothreitol, at 37°C
-
0.01274
chalcone phenyl hydrazone
pH 6, 37°C
0.0000003 - 0.00000125
chicken cystatin
-
0.000072
CPI-H
-
pH 6.2, 30°C
-
0.00011
CPI-L
-
pH 6.2, 30°C
-
0.000029
cystatin
-
-
-
0.42
di-(2-ethylhexyl)phthalate
-
wild type enzyme, in 0.4 M sodium potassium phosphate buffer (pH 6.0) containing 8 mM dithiothreitol and 4 mM EDTA, at 37°C
0.64
dibutyl phthalate
-
wild type enzyme, in 0.4 M sodium potassium phosphate buffer (pH 6.0) containing 8 mM dithiothreitol and 4 mM EDTA, at 37°C
0.13 - 0.132
ethyl (1R,2S)-2-([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)cyclohexane-1-carboxylate
0.038 - 0.162
ethyl 1-(5-nitroquinolin-8-yl)piperidine-4-carboxylate
0.129 - 0.156
ethyl 4-[(8-hydroxy-5-nitroquinolin-7-yl)methyl]piperazine-1-carboxylate
3.3
Gly-Pro-Phe-Pro-Ile
-
30°C
0.0038
human albutensin
-
pH 5.5, 37°C
0.000225
human cystatin A
-
pH 6.0, 22°C
-
0.0022
human cystatin B
-
pH 6.0, 22°C
-
0.000093
Human cystatin C
-
pH 6.0, 22°C
-
0.000015 - 0.000017
leupeptin
-
-
0.105 - 0.155
N,N-dimethyl-1-(5-nitroquinolin-8-yl)piperidine-3-carboxamide
0.185
N-(1-cyanocyclopropyl)-8-hydroxy-5-nitroquinoline-7-carboxamide
substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication
0.19 - 0.24
N-(cyanomethyl)-5-nitroquinoline-8-carboxamide
0.16 - 0.201
N-(cyanomethyl)-8-hydroxy-5,7-dinitroquinoline-2-carboxamide
0.128
N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamide
substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication
0.01767
N-acetyl-3,5-diphenyl pyrazolines
pH 6, 37°C
0.06711
N-acetyl-5-(4-bromophenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
0.1087
N-acetyl-5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
0.149
N-acetyl-5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
1.25
N-acetyl-5-(4-methylphenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
0.01141
N-acetyl-5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
pH 6, 37°C
0.00012
N-alpha-[(benzyloxy)carbonyl]-N-[(3S)-1-[(2,6-dimethylbenzoyl)oxy]-7-[(6-[(2Z)-2-[(2E,4E)-5-(1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium-2-yl)penta-2,4-dien-1-ylidene]-3,3-dimethyl-5-sulfo-2,3-dihydro-1H-indol-1-yl]hexanoyl)amino]-2-oxoheptan-3-yl]-L-phenylalaninamide
pH 6, 37°C
0.00115
N-benzoyl-3,5-diphenylpyrazoline
pH 6, 37°C
0.000775
N-benzoyl-5-(2-chloro phenyl)-3-phenylpyrazoline
pH 6, 37°C
0.004901
N-benzoyl-5-(2-methoxyphenyl)-3-phenylpyrazoline
pH 6, 37°C
0.000572
N-benzoyl-5-(2-nitrophenyl)-3-phenylpyrazoline
pH 6, 37°C
0.000677
N-benzoyl-5-(3-chloro phenyl)-3-phenylpyrazoline
pH 6, 37°C
0.001594
N-benzoyl-5-(3-methoxy phenyl)-3-phenylpyrazoline
pH 6, 37°C
0.000195
N-benzoyl-5-(3-nitrophenyl)-3-phenylpyrazoline
pH 6, 37°C
0.000925
N-benzoyl-5-(4-chloro phenyl)-3-phenylpyrazoline
pH 6, 37°C
0.001277
N-benzoyl-5-(4-methoxy phenyl)-3-phenylpyrazoline
pH 6, 37°C
0.000287
N-benzoyl-5-(4-nitrophenyl)-3-phenylpyrazoline
pH 6, 37°C
0.349 - 0.364
N-benzyl-5-nitroquinolin-8-amine
0.035
N-benzyl-N-(cyanomethyl)-8-hydroxy-5,7-dinitroquinoline-2-carboxamide
substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication
0.156
N-benzyl-N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-2-carboxamide
substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication
0.182 - 0.185
N-benzyl-N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamide
0.196 - 0.242
N-benzyl-N-methyl-5-nitroquinolin-8-amine
0.0000227
N-formyl-3,5-diphenylpyrazoline
pH 6, 37°C
0.000018
N-formyl-5-(2-chlorophenyl)-3-phenylpyrazoline
pH 6, 37°C
0.0000668
N-formyl-5-(2-methoxyphenyl)-3-phenylpyrazoline
pH 6, 37°C
0.0000141
N-formyl-5-(2-nitrophenyl)-3-phenylpyrazoline
pH 6, 37°C
0.0000146
N-formyl-5-(3-chlorophenyl)-3-phenylpyrazoline
pH 6, 37°C
0.0000455
N-formyl-5-(3-methoxyphenyl)-3-phenylpyrazoline
pH 6, 37°C
0.0000011
N-formyl-5-(3-nitrophenyl)-3-phenylpyrazoline
pH 6, 37°C
0.0000211
N-formyl-5-(4-chlorophenyl)-3-phenylpyrazoline
pH 6, 37°C
0.0000448
N-formyl-5-(4-methoxyphenyl)-3-phenylpyrazoline
pH 6, 37°C
0.0000113
N-formyl-5-(4-nitrophenyl)-3-phenylpyrazoline
pH 6, 37°C
0.0011
N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
-
0.000064
N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
-
0.0000785
oryzacystatin-1
-
in 100 mM sodium acetate pH 5.5, 2.5 mM dithiothreitol, at 37°C
-
0.0000112
oryzacystatin-1 clone A10
-
in 100 mM sodium acetate pH 5.5, 2.5 mM dithiothreitol, at 37°C
-
0.24
penetratin
-
pH 5.5
0.00087
phenylacetyl hydrazine
pH 5, 37°C
2.31
Pro-Phe-Pr-Gly-Pro-Ile
-
30°C
0.000215
sheep cystatin B
-
pH 6.0, 22°C
-
0.00000083
Z-Arg-Gly-Pro-Agly-Gly-Glu-OMe
-
0.0000000011
Z-Arg-Leu-His-Agly-Ile-Val-OMe
-
0.0000000086
Z-Arg-Leu-Phe-Agly-Val-Ala-OMe
-
0.0000075
Z-Arg-Leu-Val-Agly-Gly-Asp-OMe
-
0.000007
Z-Arg-Leu-Val-Agly-Gly-Glu-OMe
-
0.000000052
Z-Arg-Nle-Val-Agly-Gly-Glu-OMe
-
0.0048 - 0.0113
[2-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethylamino]-2-oxoethyl] 2-(furan-2-carbonylamino) acetate
0.1675
[N-benzyl-N,N-diethylethanaminium]2 hexachloro-lambda6-tellane
-
pH 6.5, 25°C
additional information
(2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide