3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.1 cathepsin B

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Results	in table
113	Activating Compound
1179	AA Sequence
43	Application
1	CAS Registry Number
62	Cloned(Commentary)
9	Crystallization (Commentary)
7005	Disease/ Diagnostics
31	Expression
103	General Information
7	General Stability
260	IC50 Value
957	Inhibitors
32	kcat/KM [mM/s]
177	Ki Value [mM]
223	KM Value [mM]
126	Localization
3	Metals/Ions
104	Molecular Weight [Da]
115	Natural Substrates/ Products (Substrates)
5	Organic Solvent Stability
986	Organism
60	PDB ID
120	pH Optimum
32	pH Range
21	pH Stability
5	pI Value
38	Posttranslational Modification
61	Protein Variants
74	Purification (Commentary)
5	Reaction
2	Reaction Type
299	Reference
3	Renatured (Commentary)
440	Source Tissue
56	Specific Activity [micromol/min/mg]
5	Storage Stability
617	Substrates and Products (Substrate)
47	Subunits
199	Synonyms
70	Temperature Optimum [°C]
8	Temperature Range [°C]
16	Temperature Stability [°C]
54	Turnover Number [1/s]

General Stability

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General Stability on EC 3.4.22.1 - cathepsin B

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

CM-cellulose and 1% CaCl2 concentration for cationic solution and 3% sodium alginate concentration for anionic solution, the encapsulated enzyme can retain about 60-70% of the immobilized activity even after five batch reactions whereas at other concentrations of CM-cellulose (2.0-3.0%), CaCl2 (1.5-2.5%) and sodium alginate (1.0-2.0%), the retention of enzyme activity is less (about 28-50%)

Capra aegagrus

-

679565

deglycosylation compromises CmCatB stability

Callosobruchus maculatus

-

708228

enzyme stability in cysteine-containing buffers depends on pH-value, half-life of enzyme at pH 7.0 is about 150 sec, at pH 6.0 about 650 sec, activity of enzyme is similar in both conditions

Bos taurus

-

650465

glycerol stabilizes

Artemia sp.

-

36633

tetrathionate stabilizes

Oryctolagus cuniculus

-

34989

the encapsulated form of enzyme can retain about 60% of its original activity during its reusability for more than five successive batch reactions, the percent-encapsulated activity is about 53% at 4% CM-cellulose concentration, at 4%

Capra aegagrus

-

679565

unstable in absence of thiol compounds

Homo sapiens

-

36647