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3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Word Map on EC 3.4.22.1

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.1 cathepsin B

pH Optimum

pH Optimum on EC 3.4.22.1 - cathepsin B

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.3
-
collagen as substrate
4 - 5
4.1
-
hemoglobin or ovalbumin as substrate
4.2 - 4.7
Dorytheuthis bleekeri
-
-
4.4 - 5.5
attack from C-terminus
4.5 - 5.5
4.5 - 6
4.5 - 6.5
with Z-Arg-Phe-7-amido-4-methylcoumarin, Z-Arg-Val-7-amido-4-methylcoumarin or Z-Arg-Leu-7-amido-4-methylcoumarin as substrate
4.8
-
assay at
5 - 6.5
with Z-Arg-Val-7-amido-4-methylcoumarin as substrate
5.2
-
assay at
5.5 - 6.5
with Z-Arg-Arg-7-amido-4-methylcoumarin as substrate
5.5 - 7
-
catB1shows optimal activity within this range
6 - 6.5
-
encapsulated enzyme
6 - 7
6.1
-
-
6.2 - 6.4
6.4
-
-
6.7
-
benzoyl-DL-Arg-p-nitroanilide substrate
7.6
-
hydrolytic enzyme assay at
8
-
azocasein as substrate