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3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Word Map on EC 3.4.22.1

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.1 cathepsin B

Turnover Number

Turnover Number on EC 3.4.22.1 - cathepsin B

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.9
Abz-FRF(NO2)A
37°C, pH 4.5
43
Abz-GIVRAK(Dnp)-OH
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37°C
0.1
Abz-GIVRAK-Dnp
37°C, pH 4.5
0.004
Arg-4-methylcoumaryl-7-amide
-
-
0.000000001
azocasein
-
-
-
0.075
benzoyl-DL-Arg-beta-naphthylamide
-
-
83
benzoyl-DL-Arg-p-nitroanilide
-
-
8.12
benzoyl-Phe-Val-Arg-4-methylcoumaryl-7-amide
-
-
0.125 - 87
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide
0.139
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide
-
-
0.149 - 158
benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
11
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin
37°C, pH 4.5
0.327 - 0.512
benzyloxycarbonyl-L-leucyl-L-arginine-4-methylcoumaryl-7-amide
0.318 - 0.476
benzyloxycarbonyl-L-phenylalaninyl-L-arginine 4-methylcoumaryl-7-amide
0.445 - 364
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide
4.7
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
37°C, pH 4.5
0.325 - 68
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide
0.28
Boc-Asp-Pro-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
0.69
Boc-Asp-Pro-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
3.38
Boc-Val-Leu-Lys-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
0.72
Boc-Val-Pro-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.000625
Collagen
-
-
0.14
D-Val-Leu-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.00000000817
gelatin
-
-
-
0.011
N,N'-diBoc-dityrosine-Gly-(isoniazid)2
pH 6.2, 25°C
0.036
N,N'-diBoc-dityrosine-Lys-(isoniazid)2
pH 6.2, 25°C
1.09
N-benzyloxycarbonyl-Arg-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
0.13
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
1.71
N-benzyloxycarbonyl-Phe-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
0.19
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.51
N-benzyloxycarbonyl-Val-Ile-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
34 - 67
Nalpha-benzoyl-Arg-Arg-7-amido-4-methylcoumarin
86 - 115
Nalpha-benzoyl-Phe-Arg-7-amido-4-methylcoumarin
277.6
Nalpha-carbobenzoxy-L-Arg-L-Arg-7-amido-4-trifluoromethylcoumarin
recombinant enzyme, at pH 7.3 and 37°C
2.26
Tos-Gly-Pro-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
0.13
Tos-Gly-Pro-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C