EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
neuron |
- |
763094 |
1.1.1.188 | prostaglandin-F synthase |
neuron |
dendrites and somata, isozyme PGF synthase I |
655139 |
1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase |
neuron |
adult and fetal |
670476 |
1.1.1.27 | L-lactate dehydrogenase |
neuron |
activities of both H- and M-isoforms of LDH are high but neurons show a dominance of H-isoform activity |
700452 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
neuron |
- |
673822 |
1.1.1.284 | S-(hydroxymethyl)glutathione dehydrogenase |
neuron |
- |
726053 |
1.1.1.31 | 3-hydroxyisobutyrate dehydrogenase |
neuron |
- |
688515 |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
neuron |
- |
763094 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
neuron |
- |
656588 |
1.1.1.95 | phosphoglycerate dehydrogenase |
neuron |
- |
738901 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
neuron |
- |
764701 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
neuron |
endogenous GPX4 is mainly expressed in neurons, usage of primary cultured cortical neurons |
-, 765297 |
1.11.1.9 | glutathione peroxidase |
neuron |
- |
685439 |
1.11.1.9 | glutathione peroxidase |
neuron |
upregulated Gpx-1 activity is associated with neuroprotection in vitro |
673250 |
1.13.11.11 | tryptophan 2,3-dioxygenase |
neuron |
- |
743358 |
1.13.11.31 | arachidonate 12-lipoxygenase |
neuron |
primary cortical culture |
689218 |
1.13.11.31 | arachidonate 12-lipoxygenase |
neuron |
primary cortical neurons, increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain |
-, 743056 |
1.13.11.33 | arachidonate 15-lipoxygenase |
neuron |
primary cortical neurons, increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain |
-, 743056 |
1.13.11.40 | arachidonate 8-lipoxygenase |
neuron |
nervous tissue |
439400 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
neuron |
- |
743358 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
neuron |
the enzyme is upregulated by interferon-gamma in neurons of the hippocampus. The enzyme could contribute to the vulnerability of neurons to inflammatory conditions |
666461 |
1.14.11.53 | mRNA N6-methyladenine demethylase |
neuron |
Alkbh5 is mainly colocalized with neuronal marker NeuN |
764386 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
neuron |
- |
754882 |
1.14.11.68 | [histone H3]-trimethyl-L-lysine27 demethylase |
neuron |
primary adult murine trigeminal ganglion neuron |
754544 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
- |
-, 440226, 440233, 658119, 672363, 674558, 675520, 687697, 687734, 711646, 711779, 745293, 745299, 745379, 764938 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
amacrine |
672844 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
central nervous system, natural variant with 105-amino acid deletion in the heme-binding domain |
440217 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
comparison of endothelial and neuronal isoform |
658116 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
isozyme NOS1 |
673804 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
neuronal NOS, nNOS |
686293 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
neurons of several nuclei of the hypothalamus, such as the arcuate nucleus (ARC) and paraventricular nucleus (PVN) |
-, 763849 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
nitrergic neurons in the rat stomach, the myenteric cell bodies have single axons, type I morphology and a wide range of sizes. Nitrergic terminals do not provide baskets of terminals around myenteric neurons. The nitrergic neuron populations in the stomach supply the muscle layers and intramural arteries, but, unlike in the intestine, gastric interneurons do not express nNOS |
-, 764443 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
nNOS |
687358 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
peripheral nitrergic nerves, isoform I |
440226 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neuron |
the NADPH-d histochemistry stains a selective population of neurons in the brain. The staining allows the visualization of the dendritic tree, resembling a Golgi impregnation, and the cells are distributed sparsely in the cortical tissue, allowing their unbiased identification and reconstruction, quantitative analysis, overview |
-, 764565 |
1.14.13.9 | kynurenine 3-monooxygenase |
neuron |
- |
743358, 763915 |
1.14.13.9 | kynurenine 3-monooxygenase |
neuron |
adult and fetal |
763915 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
neuron |
- |
685906, 686269, 690143, 705913 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
neuron |
immortalized hypothalamic neurons GT1-7 |
689226 |
1.14.14.25 | cholesterol 24-hydroxylase |
neuron |
- |
-, 671173, 687987, 705612, 712869, 735602, 735877 |
1.14.14.25 | cholesterol 24-hydroxylase |
neuron |
expression in cell bodies, dendrites, and axons |
-, 712120 |
1.14.14.25 | cholesterol 24-hydroxylase |
neuron |
hippocampal |
675535 |
1.14.14.25 | cholesterol 24-hydroxylase |
neuron |
in normal brain |
659374 |
1.14.14.25 | cholesterol 24-hydroxylase |
neuron |
large pyramidal cells and their dendrites in cortical layers II, III, V, and VI. Is absent from nonpyramidal cells that compose layer IV |
701715 |
1.14.14.25 | cholesterol 24-hydroxylase |
neuron |
of the neural retina, specific expression of CYP46A1 |
686258 |
1.14.14.25 | cholesterol 24-hydroxylase |
neuron |
primary hippocampal neurons |
688555 |
1.14.15.15 | cholestanetriol 26-monooxygenase |
neuron |
- |
705935 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
- |
685885, 687935, 688521, 688545, 689223, 699251, 700464 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
amount of immunoreactive neurons in seizure-sensitive and seizure-resistant gerbils, overview |
688723 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
dopaminergic neurons |
690099 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
fibers and puncta |
687936 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
hypothalamic domainergic neurons |
687055 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
interneurons in developing brain tissue, complete absence of cell death markers, i.e. active caspase 3, suggests that cortical tyrosine hydroxylase-immunoreactive neurons are not a transient population of cells, overview |
685887 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
mid brain dopamine neuron |
695599 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
midbrain dopaminergic neurons, expression analysis in situ |
689074 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
myenteric, about 16% of the total number of axosomatic terminals show tyrosine hydroxylase immunoreactivity |
687937 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
non-monoaminergic neurons, immunohistochemic analysis of enzyme distribution, overview |
684220 |
1.14.16.2 | tyrosine 3-monooxygenase |
neuron |
olfactory and sensory neurons, cholinergic and adrenergic pathways modulate the proprotion of tyrosine hydroxylase-immunoreactive neurons, KCl induces the number of positive TH-IR neurons involving L-type Ca2+ channels, overview |
688624 |
1.14.16.4 | tryptophan 5-monooxygenase |
neuron |
- |
686011, 689062, 689206, 727949 |
1.14.16.4 | tryptophan 5-monooxygenase |
neuron |
expressed predominantly in serotonergic neurons |
673005 |
1.14.16.4 | tryptophan 5-monooxygenase |
neuron |
neural isozyme TPH2 |
689089 |
1.14.16.4 | tryptophan 5-monooxygenase |
neuron |
primary serotonergic, from raphe nuclei |
685470 |
1.14.16.4 | tryptophan 5-monooxygenase |
neuron |
serotonergic |
684239, 689228 |
1.14.16.4 | tryptophan 5-monooxygenase |
neuron |
serotonergic, expression of TPH2 |
689086 |
1.14.16.4 | tryptophan 5-monooxygenase |
neuron |
TPH2, serotonergic neurons |
689088 |
1.14.16.4 | tryptophan 5-monooxygenase |
neuron |
TPHexpressing neurons form two clusters in the anterior central nervous system at the level of the visceral ganglion |
686289 |
1.14.17.1 | dopamine beta-monooxygenase |
neuron |
axons expressing dopamine beta hydroxyase frequenty made appositions to sympathetic and parasympathetic preganglionic neurons |
676190 |
1.14.17.1 | dopamine beta-monooxygenase |
neuron |
neurons in primary neural crest stem cell culture |
689180 |
1.14.17.3 | peptidylglycine monooxygenase |
neuron |
- |
658685 |
1.14.18.9 | 4alpha-methylsterol monooxygenase |
neuron |
- |
688660 |
1.16.1.10 | ferric-chelate reductase [NAD(P)H] |
neuron |
hippocampal primary neuron cultures |
-, 744983 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
neuron |
- |
656591, 676319, 740884 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
neuron |
cerebellar granule neurons |
675552 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
neuron |
hippocampal neuron |
700476 |
1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
neuron |
striatal |
287982 |
1.2.1.25 | branched-chain alpha-keto acid dehydrogenase system |
neuron |
- |
763513 |
1.2.1.25 | branched-chain alpha-keto acid dehydrogenase system |
neuron |
primary cortical neuronal cultures |
-, 763378 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
neuron |
- |
693766 |
1.2.4.2 | oxoglutarate dehydrogenase (succinyl-transferring) |
neuron |
hippocampal neuron |
699606 |
1.2.4.4 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) |
neuron |
- |
725082, 763513 |
1.3.1.24 | biliverdin reductase |
neuron |
- |
673797, 711794 |
1.3.1.72 | DELTA24-sterol reductase |
neuron |
- |
746255 |
1.3.5.2 | dihydroorotate dehydrogenase (quinone) |
neuron |
- |
713150 |
1.3.8.6 | glutaryl-CoA dehydrogenase (ETF) |
neuron |
striatal, from neonatal rats |
-, 726334 |
1.3.8.8 | long-chain acyl-CoA dehydrogenase |
neuron |
- |
653212, 671275 |
1.4.1.27 | glycine cleavage system |
neuron |
P-protein mRNA is expressed mainly in glia-like cells, including Bergmann glias in the cerebellum, while T- and H-protein mRNAs are detected in both glial-like cells and neurons |
758983 |
1.4.1.3 | glutamate dehydrogenase [NAD(P)+] |
neuron |
- |
-, 712827, 763376 |
1.4.3.1 | D-aspartate oxidase |
neuron |
primary cultured |
711719 |
1.4.3.5 | pyridoxal 5'-phosphate synthase |
neuron |
- |
705930 |
1.5.1.1 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] |
neuron |
- |
743355 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
neuron |
- |
743355 |
1.5.1.25 | thiomorpholine-carboxylate dehydrogenase |
neuron |
- |
743355 |
1.6.2.2 | cytochrome-b5 reductase |
neuron |
neuronal synaptic plasma membrane vesicles |
765742 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
neuron |
- |
713338 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
neuron |
dorsomedial nucleus tractus solitarius neuron. In small dendritic processes, both angiotensin II and phenylephrine produce a decrease in intracellular subunit p47phox labeling selectively in dorsomedial nucleus tractus solitarius neurons. In intermediate-size dendritic profiles in the dorsomedial nucleus tractus solitarius region only, there is an increase in p47phox labeling in response to each hypertensive agent, although these changes occurre in different subcellular compartments. There is an increase in non-vesicular labeling in response to angiotensin II, but an increase in surface labeling with phenylephrine |
686602 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
neuron |
in primary cultures of cerebellar granule neuron, expression of the components of NADPH oxidase proteins, p40phox, p47phox and p67phox,and p22phox, as well as three homologues of the catalytic subunit, NOX1, 2, and 4 |
686883 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
neuron |
isoforms NOX2 and NOX3 |
742567 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
neuron |
- |
691553 |
1.6.99.1 | NADPH dehydrogenase |
neuron |
hippocampal neuron, experimental epilepsy induced in rats by infusion of kainic acid into the lateral cerebral ventricles decreases the number of NADPH-diaphorase-positive neurons in the hippocampal formation by 55-79% |
672861 |
1.6.99.1 | NADPH dehydrogenase |
neuron |
medium and small, more common in neurons from ipsilateral ganglia |
724683 |