Protein Variants | Comment | Organism |
---|---|---|
additional information | neuroblastoma N2A cells are infected with adenovirus expressing myc-tagged DHCR24 (Ad-DHCR24) or lacZ (Ad-lacZ, serving as a control) and subjected to endoplasmic reticulum-stress, induced with tunicamycin. Cells infected with Ad-DHCR24-myc are resistant to TM-induced apoptosis, and show weaker level of caspase-12 activity. The cells also exhibit lower levels of Bip and CHOP proteins than Ad-LacZ-infected cells. A stronger and rapid activation of PERK, and a prolonged activation of JNK and p38 are observed in Ad-LacZinfected cells. The generation of intracellular reactive oxygen species from endoplasmic reticulum stress is also diminished by the overexpression of DHCR24 and intracellular cholesterol level is elevated, accompanied by a well-organized formation of caveolae (cholesterol-rich microdomain) on the plasma membrane, and improved colocalization of caveolin-1 and insulin-like growth factor 1 receptor. DHCR24 can protect neuronal cells from apoptosis induced by endoplasmic reticulum stress | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15392 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
additional information | not in glial cells | Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
3 beta-hydroxysteroid-DELTA 24 reductase | - |
Homo sapiens |
DHCR24 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | 3beta-hydroxysteroid-DELTA24 reductase (DHCR24) is an endoplasmic reticulum-localized multifunctional enzyme that possesses anti-apoptotic and cholesterol-synthesizing activities. Overexpression of DHCR24 protects neuronal cells from tunicamycin-induced apoptosis. DHCR24 may function as a neuroprotective protein under endoplasmic reticulum stress. Overexpression of DHCR24 inhibits apoptotic cell signaling and reduces or delays activation of endoplasnic reticlum stress-related cell signaling during unfolded protein response in mouse embryonic fibroblast N2A cells, overview. Elevated cholesterol levels may contribute to the neuroprotective function of DHCR24 | Homo sapiens |