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Information on EC 1.14.14.25 - cholesterol 24-hydroxylase

for references in articles please use BRENDA:EC1.14.14.25
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IUBMB Comments
A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol . This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood---brain barrier whereas cholesterol cannot . The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase .
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The enzyme appears in viruses and cellular organisms
Synonyms
cyp46a1, cyp46, cholesterol 24s-hydroxylase, cytochrome p450 46a1, cholesterol-24s-hydroxylase, 24s-hydroxylase, cyp46a, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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