Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate | i.e. 8-CPTcAMP, tyrosine hydroxylase protein level and activity rate are increased in MN9D cells in response to treatment with 8-CPTcAMP, mechanism, overview | Mus musculus | |
forskolin | i.e. 8-CPTcAMP, tyrosine hydroxylase protein level and activity rate are increased in MN9D cells in response to treatment with 8-CPTcAMP, mechanism, overview | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of an enzyme-luciferase fusion protein in MN9D cells, quantitative PCR-based enzyme expression analysis, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Mus musculus | - |
3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
midbrain | midbrain dopaminergic neurons, expression analysis in situ | Rattus norvegicus | - |
MN9D cell | a hybrid cell line derived from the fusion of mouse neuroblastoma N18TG2 cells with embryonic mouse mesencephalic neurons, tyrosine hydroxylase polysome profile analysis, overview | Mus musculus | - |
N18TG2 cell | - |
Mus musculus | - |
neuron | midbrain dopaminergic neurons, expression analysis in situ | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
additional information | - |
- |
Rattus norvegicus |
0.0002 | - |
about, MN9D cells | Mus musculus |
0.00045 | - |
about, MN9D cells induced by forskolin or 8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + 6-methyltetrahydrobiopterin + O2 | - |
Mus musculus | 3,4-dihydroxy-L-phenylalanine + 6-methyl-4a-hydroxytetrahydrobiopterin | - |
? | |
L-tyrosine + 6-methyltetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 6-methyl-4a-hydroxytetrahydrobiopterin | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | - |
Mus musculus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Mus musculus |
tyrosine hydroxylase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Mus musculus |
6.8 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
6-Methyl-5,6,7,8-tetrahydropterin | - |
Mus musculus | |
6-Methyl-5,6,7,8-tetrahydropterin | - |
Rattus norvegicus | |
tetrahydrobiopterin | - |
Mus musculus | |
tetrahydrobiopterin | - |
Rattus norvegicus |