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Information on EC 1.14.16.2 - tyrosine 3-monooxygenase

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IUBMB Comments
The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by EC 2.7.11.27, [acetyl-CoA carboxylase] kinase. The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34 (6,7-dihydropteridine reductase), or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
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The enzyme appears in viruses and cellular organisms
Synonyms
tyrosine hydroxylase, cat-2, monophenol monooxygenase, tyrosine-3-monooxygenase, tyrosine 3-hydroxylase, l-tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-tyrosine + tetrahydrobiopterin + O2 = L-dopa + 4a-hydroxytetrahydrobiopterin
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