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Literature summary for 1.14.16.2 extracted from

  • Tank, A.W.; Xu, L.; Chen, X.; Radcliffe, P.; Sterling, C.R.
    Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain (2008), Ann. N. Y. Acad. Sci., 1148, 238-248.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.2

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
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 Rattus norvegicus
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brain
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 Rattus norvegicus
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neuron mid brain dopamine neuron Rattus norvegicus
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PC-12 cell
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
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 Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
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 ?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
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 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus neither forskolin, nor phorbol esters or stimulatory agonists like glutamate, neurotensin, muscarine, nicotine or pituitary adenylate cyclase-activating peptide reproducibly induce tyrosine hydroxylase mRNA in the midbrain. When midbrain slices are treated with 1 mM 8-(4-chlorophenylthio)-cAMP or 0.01 mM forskolin, there is no induction of tyrosine hydroxylase mRNA. additional information
Rattus norvegicus long-term stress from hypoxia leads to induction of tyrosine hydroxylase mRNA and protein in adrenal medulla and brain, this induction is usually associated with stimulation of tyrosine hydroxylase gene transcription rate. Tyrosine hydroxylase mRNA increases 8fold at 3 h after immobilization of rats and remains elevated about 2fold after 24 h. Tyrosine hydroxylase gene transcription increases in response to nicotine or stress. cAMP is a powerful inducer of both tyrosine hydroxylase mRNA and protein. up