Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation at Ser40 activates the enzyme, the phosphorylation is inhibited by alpha-synuclein, up to 183% induced by amphetamines, the phosphorylation inhibition is inhibited by melatonin, mechanisms, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation at Ser40 activates the enzyme, the phosphorylation is inhibited by alpha-synuclein, up to 183% induced by amphetamines, the phosphorylation inhibition is inhibited by melatonin, mechanisms, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Homo sapiens | key and rate-limiting enzyme in dopamine and other catecholamine biosynthesis, regulation, mechanisms, overview | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at Ser40 activates the enzyme, the phosphorylationis inhibited by alpha-synuclein, up to 183% induced by amphetamines, the phosphorylation inhibition is inhibited by melatonin, mechanisms, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
SK-N-SH cell | a dopaminergic cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | key and rate-limiting enzyme in dopamine and other catecholamine biosynthesis, regulation, mechanisms, overview | Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Homo sapiens |