EC Number   |
Natural Substrates |
|---|
    1.14.16.2 | L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2 |
first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine |
| 1.14.16.2 | L-tyrosine + (6R)-L-erythro-tetrahydrobiopterin + O2 |
probable regulatory role of cosubstrate for all 4 isoforms |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 |
- |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 |
best substrate |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 |
first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 |
reaction is coupled with ascorbate oxidation |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 |
rate-limiting step in catecholamine biosynthesis |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 |
the enzyme prefers L-tyrosine as a substrate over L-phenylalanine by an order of magnitude and over L-tryptophan by 25fold |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 |
the enzyme shows high substrate specificity for L-tyrosine |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 |
regulation, overview |
