Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation at Ser40 in the regulatory domain activates the enzyme, the activation is inhibited by alpha-synuclein | Mus musculus |
Application | Comment | Organism |
---|---|---|
diagnostics | tyrosine hydroxylase is frequently used as a marker of dopaminergic neuronal loss in animal models of Parkinsons disease | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | reduction of high-level tyrosine hydroxylase dopaminergic alpha-Syn-deficient cells by infection with wild-type alpha-Syn human lentivirus, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | alpha-synuclein inhibits the enzyme by inhibiting enzyme phosphorylation at Ser40 in the regulatory domain, aggregated alpha-Syn is no longer able to inhibit tyrosine hydroxylase, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Mus musculus | tyrosine hydroxylase is the rate limiting enzyme in catecholamine synthesis, and is involved in Parkinson's disease, enzyme inhibition by alpha-synuclein causes the dopaminergic phenotype, overview | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male ASKO mice, strain B6:129X1-Snca | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | short term regulation of tyrosine hydroxylase depends on the phosphorylation of seryl residues, Ser19, Ser31, and Ser40, in the TH regulatory domain, activating phosphorylation at Ser40 is inhibited by alpha-synuclein | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
additional information | immunohistochemic enzyme analysis in brain slices, overview | Mus musculus | - |
olfactory bulb | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Mus musculus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | tyrosine hydroxylase is the rate limiting enzyme in catecholamine synthesis, and is involved in Parkinson's disease, enzyme inhibition by alpha-synuclein causes the dopaminergic phenotype, overview | Mus musculus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Mus musculus |