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Literature summary for 1.14.16.2 extracted from

  • Oka, K.; Kato, T.; Sugimoto, T.; Matsuura, S.; Nagatsu, T.
    Kinetic properties of tyrosine hydroxylase with natural tetrahydrobiopterin as cofactor (1981), Biochim. Biophys. Acta, 661, 45-53.
    View publication on PubMed
Search for more literature for 1.14.16.2

Inhibitors

Inhibitors Comment Organism Structure
O2 above 4.8% Bos taurus
tyrosine 0.1 mM Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km is dependent on substrate and cofactor concentration when (6R)-L-erythro-tetrahydrobiopterin is used due to inhibitory effects Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Bos taurus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
280000
-
 gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2 Bos taurus first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine ?
-
 ?
L-tyrosine + tetrahydrobiopterin + O2 Bos taurus first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from adrenal medulla Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.21
-
 purified enzyme Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2 first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine Bos taurus ?
-
 ?
L-tyrosine + (6R)-L-erythro-tetrahydrobiopterin + O2 tyrosine at 0.1 mM and O2 at 4.8% inhibit with (6R)-L-erythro-tetrahydrobiopterin as electron donor, depending on O2 and cofactor concentration Bos taurus ?
-
 ?
L-tyrosine + tetrahydrobiopterin + O2
-
 Bos taurus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
L-tyrosine + tetrahydrobiopterin + O2 first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine Bos taurus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus