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Literature summary for 1.14.16.2 extracted from
- A small dopamine permeability of storage vesicle membranes and end product inhibition of tyrosine hydroxylase are sufficient to explain changes occurring in dopamine synthesis and storage after inhibition of neuron firing (2007), Synapse, 61, 715-723.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dopamine | end product inhibition | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | key enzyme in dopamine biosynthesis, the majority of dopamine is derived from recycling after dopamine exocytosis, but loss in dopamine leads to de novo synthesis of dopamine, due to increased enzyme activity since the feedback enzyme inhibition by dopamine is reduced, regulation, overview | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| corpus striatum | - |
Rattus norvegicus | - |
| neuron | dopaminergic neurons | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
| L-tyrosine + tetrahydrobiopterin + O2 | key enzyme in dopamine biosynthesis, the majority of dopamine is derived from recycling after dopamine exocytosis, but loss in dopamine leads to de novo synthesis of dopamine, due to increased enzyme activity since the feedback enzyme inhibition by dopamine is reduced, regulation, overview | Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tyrosine hydroxylase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| tetrahydrobiopterin | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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