Literature summary for 1.14.16.2 extracted from

Perfume, G.; Morgazo, C.; Nabhen, S.; Batistone, A.; Hope, S.I.; Bianciotti, L.G.; Vatta, M.S.
Short-term regulation of tyrosine hydroxylase activity and expression by endothelin-1 and endothelin-3 in the rat posterior hypothalamus (2007), Regul. Pept., 142, 69-77.

Search for more literature for 1.14.16.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	no activation by ETA and ETB selective agonists sarafotoxin S6b and IRL-1620, respectively	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	endothelin-1 and endothelin-3 inhibit the enzyme by inhibiting enzyme phosphorylation at Ser19, Ser31, and Ser40, but the response is abolished by selective ETA and ETB antagonists BQ-610 and BQ-788, respectively. The inhibitory effect of endothelins is also reversed by Nomega-nitro-L-arginine methyl ester and 7-nitroindazole, 1H-[1,2,4]-oxadiazolo[4,3-alpha]quinozalin-1-one, and KT-5823, respectively, no inhibition of tyrosine hydroxylase by ETA and ETB selective agonists sarafotoxin S6b and IRL-1620, respectively, detailed overview	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	Rattus norvegicus	-	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male sprague-dawley rats	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	the enzyme is phosphorylated at Ser19, Ser31, and Ser40, leading to its activation	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
hypothalamus	posterior	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + 6-methyltetrahydrobiopterin + O2	-	Rattus norvegicus	3,4-dihydroxy-L-phenylalanine + 6-methyl-4a-hydroxytetrahydrobiopterin	-	?
L-tyrosine + tetrahydrobiopterin + O2	-	Rattus norvegicus	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Synonyms

Synonyms	Comment	Organism
tyrosine hydroxylase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	assay at	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
6-methyltetrahydrobiopterin	-	Rattus norvegicus
tetrahydrobiopterin	-	Rattus norvegicus

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Release 2023.1 (January 2023)