Cloned (Comment) | Organism |
---|---|
expression as His-tagged protein in Escherichia coli, amino acid sequence analysis | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Catecholamines | - |
Schistosoma mansoni | |
tyrosine | at concentrations above 0.03 mM | Schistosoma mansoni |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0095 | - |
tyrosine | - |
Schistosoma mansoni | |
0.045 | - |
tetrahydrobiopterin | - |
Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant from Escherichia coli | Schistosoma mansoni |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00003 | - |
crude extract | Schistosoma mansoni |
0.78 | - |
purified enzyme | Schistosoma mansoni |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | tetrahydropterin absolutely required | Schistosoma mansoni | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | 3,4-dihydroxy-L-phenylalanine is identical with dopa | ? | |
L-tyrosine + tetrahydrobiopterin + O2 | - |
Schistosoma mansoni | L-dopa + 4a-hydroxytetrahydrobiopterin + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
TH | - |
Schistosoma mansoni |