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Literature summary for 1.14.16.2 extracted from

  • He, D.Y.; Ron, D.
    Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90 (2008), J. Biol. Chem., 283, 12811-12818.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.2

Activating Compound

Activating Compound Comment Organism Structure
additional information ethanol induces the enzyme activation of the cAMP/cyclic AMP-dependent protein kinase A pathway, the activation is reversible by ibogaine via glial cell line-derived neurotrophic factor, GNDF. Ethanol treatment results in an increase in tyrosine hydroxylase association with the chaperone heat shock protein that is mediated by the cAMP/PKA pathway and inhibited by GDNF, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information glial cell line-derived neurotrophic factor, GDNF, supresses the enzyme expression in the midbrain Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Homo sapiens the glial cell line-derived neurotrophic factor, GDNF, is involved in the regulation of tyrosine hydroxylase levels in the midbrain 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein activation through phosphorylation of tyrosine hydroxylase by cyclic AMP-dependent protein kinase A, inhibited in the presence of H89 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
midbrain
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 Homo sapiens
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SH-SY5Y cell a dopaminergic-like, neuroblastoma cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
 Homo sapiens 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
L-tyrosine + tetrahydrobiopterin + O2 the glial cell line-derived neurotrophic factor, GDNF, is involved in the regulation of tyrosine hydroxylase levels in the midbrain Homo sapiens 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
 Homo sapiens