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Literature summary for 1.14.16.2 extracted from

  • Royo, M.; Colette Daubner, S.
    Kinetics of regulatory serine variants of tyrosine hydroxylase with cyclic AMP-dependent protein kinase and extracellular signal-regulated protein kinase 2 (2006), Biochim. Biophys. Acta, 1764, 786-792.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.2

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21(DE3) as His-tag fusion protein Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
S19E mimics phosphorylation at S19 Rattus norvegicus
S19E/S40E mimics phosphorylation at S19S40 Rattus norvegicus
S31E mimics phosphorylation at S31 Rattus norvegicus
S40E mimics phosphorylation at S40 Rattus norvegicus
S8E mimics phosphorylation at S8 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation occurs at S8, S19, S31 and S40. Neither cAMP-dependent protein kinase nor extracellular signal-regulated kinase 2 activity for phosphorylation of tyrosine hydroxylase is affected by pre-existing phosphorylations. Phosphorylation of S40 by cAMP-dependent protein kinase is inhibited by bound dopamine Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
Ni-affinity chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
TyrH
-
 Rattus norvegicus
tyrosine hydroxylase
-
 Rattus norvegicus