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Literature summary for 1.14.16.2 extracted from

  • Jorge-Finnigan, A.; Kleppe, R.; Jung-Kc, K.; Ying, M.; Marie, M.; Rios-Mondragon, I.; Salvatore, M.F.; Saraste, J.; Martinez, A.
    Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules (2017), J. Biol. Chem., 292, 14092-14107 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.2

Protein Variants

Protein Variants Comment Organism
S31A the mutant is not phosphorlyated Homo sapiens
S31A the mutant is not phosphorlyated Rattus norvegicus
S31E phospho-mimic mutant Homo sapiens
S31E phospho-mimic mutant Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-
Golgi apparatus
-
 Rattus norvegicus 5794
-
vesicle
-
 Homo sapiens 31982
-
vesicle
-
 Rattus norvegicus 31982
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Homo sapiens
-
 L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus
-
 L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus P04177
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at the Ser-31 site may regulate enzyme subcellular localization by enabling its transport along microtubules and is necessary for enzyme association with vesicles Homo sapiens
phosphoprotein phosphorylation at the Ser-31 site may regulate enzyme subcellular localization by enabling its transport along microtubules and is necessary for enzyme association with vesicles Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
dopaminergic neuron
-
 Homo sapiens
-
dopaminergic neuron
-
 Rattus norvegicus
-
HEK-293 cell
-
 Homo sapiens
-
PC-12 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
 Homo sapiens L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
L-tyrosine + tetrahydrobiopterin + O2
-
 Rattus norvegicus L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 60000, SDS-PAGE Homo sapiens
? x * 60000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
TH1 isoform Homo sapiens
TH1 isoform Rattus norvegicus
tyrosine hydroxylase
-
 Homo sapiens
tyrosine hydroxylase
-
 Rattus norvegicus