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Literature summary for 1.14.16.2 extracted from

  • Chaube, R.; Joy, K.P.
    In vitro effects of catecholamines and catecholestrogens on brain tyrosine hydroxylase activity and kinetics in the female catfish Heteropneustes fossilis (2003), J. Neuroendocrinol., 15, 273-279.
    View publication on PubMed
Search for more literature for 1.14.16.2

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxyestradiol-17beta noncompetitive Heteropneustes fossilis
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol competitive Heteropneustes fossilis
adrenalin competitive Heteropneustes fossilis
dopamine competitive Heteropneustes fossilis
noradrenaline
-
 Heteropneustes fossilis

Organism

Organism UniProt Comment Textmining
Heteropneustes fossilis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Heteropneustes fossilis
-
hypothalamus
-
 Heteropneustes fossilis
-
telencephalon
-
 Heteropneustes fossilis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine + O2
-
 Heteropneustes fossilis ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine
-
 Heteropneustes fossilis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.18
-
 2-hydroxyestradiol-17beta enzyme from telencephalom, resting phase Heteropneustes fossilis
0.22
-
 2-hydroxyestradiol-17beta enzyme from hypothalamus, resting phase Heteropneustes fossilis
0.25
-
 noradrenaline enzyme from hypothalamus, preparatory phase Heteropneustes fossilis
0.25
-
 2-hydroxyestradiol-17beta enzyme from telencephalon, resting phase Heteropneustes fossilis
0.28
-
 2-hydroxyestradiol-17beta enzyme from hypothalamus, preparatory phase Heteropneustes fossilis
0.28
-
 noradrenaline enzyme from telencephalon, resting phase Heteropneustes fossilis
0.3
-
 adrenaline enzyme from hypothalamus, preparatory phase Heteropneustes fossilis
0.3
-
 noradrenaline enzyme from hypothalamus, resting phase Heteropneustes fossilis
0.32
-
 noradrenaline enzyme from telencephalom, resting phase Heteropneustes fossilis
0.32
-
 adrenaline enzyme from telencephalon, resting phase Heteropneustes fossilis
0.35
-
 adrenaline enzyme from telencephalom, resting phase Heteropneustes fossilis
0.4
-
 adrenaline enzyme from hypothalamus, resting phase Heteropneustes fossilis
0.52
-
 dopamine enzyme from hypothalamus, preparatory phase Heteropneustes fossilis
0.52
-
 dopamine enzyme from telencephalon, resting phase Heteropneustes fossilis
0.6
-
 dopamine enzyme from telencephalom, resting phase Heteropneustes fossilis
0.69
-
 dopamine enzyme from hypothalamus, resting phase Heteropneustes fossilis