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Literature summary for 1.14.16.2 extracted from

  • Bodnar, I.; Hechtl, D.; Szekacs, D.; Olah, M.; Nagy, G.M.
    Effect of local (intracerebral and intracerebroventricular) administration of tyrosine hydroxylase inhibitor on the neuroendocrine dopaminergic neurons and prolactin release (2007), Ideggyogy. Sz., 60, 177-181.
    View publication on PubMed
Search for more literature for 1.14.16.2

Inhibitors

Inhibitors Comment Organism Structure
alpha-methyl-L-tyrosine in vivo injection into the neurointermediate lobe of the pituitary gland, i.e. the intracerebro-ventricular and intra-arcuatus injection, leads to reduced synthesis of dopamine and DOPA, but not of norepinephrine, and leads to increased contents of pituitary prolactin, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus the enzyme catalyzes the rate-limiting step in dopamine biosynthesis, enzyme inhibition in the brain leads to hypothalamic reduced dopamine and DOPAC levels and increased pituitary prolactine, while the norepinephrine levels remain unaltered, overview 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male Wistar rats
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation activates the tyrosine hydroxylase Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
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neuron hypothalamic domainergic neurons Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
 Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
L-tyrosine + tetrahydrobiopterin + O2 the enzyme catalyzes the rate-limiting step in dopamine biosynthesis, enzyme inhibition in the brain leads to hypothalamic reduced dopamine and DOPAC levels and increased pituitary prolactine, while the norepinephrine levels remain unaltered, overview Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
 Rattus norvegicus