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Literature summary for 1.14.16.2 extracted from

  • Wang, Y.; Sung, C.C.; Chung, K.K.
    Novel enhancement mechanism of tyrosine hydroxylase enzymatic activity by nitric oxide through S-nitrosylation (2017), Sci. Rep., 7, 44154 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.2

Activating Compound

Activating Compound Comment Organism Structure
additional information not activated by GSH Homo sapiens
nitric oxide S-nitrosylation by nitric oxide at Cys279 enhances the enzymatic activity by about 25% Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain Rosetta (DE3) pLys and HEK-293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Homo sapiens
-
 L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information nitration at N-terminal of the enzyme can inactivate its activity Homo sapiens
additional information S-glutathionylation at N-terminal of the enzyme can inactivate its activity Homo sapiens
nitrosylation the enzyme can be S-nitrosylated at Cys279 Homo sapiens
phosphoprotein phosphorylation at N-terminal of the enzyme can activate its activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
 Homo sapiens L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 58000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
 Homo sapiens