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Disease on EC 1.14.16.2 - tyrosine 3-monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
Involvement of renal sympathetic nerve activation on the progression of ischemic acute kidney injury in the mouse.
L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats.
Acute Lung Injury
Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury.
Addison Disease
Absence of autoantibodies connected to autoimmune polyendocrine syndrome type I and II and Addison's disease in girls and women with Turner syndrome.
Adenoma, Islet Cell
Tyrosine hydroxylase activity in a transplantable islet cell tumour of golden hamster.
Adenoma, Villous
Changes in vasoconstrictor and vasodilator neurotransmitters in nerves supplying arterioles in developing colorectal polyps.
Alcoholic Neuropathy
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.
Alopecia
Pteridin-dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type I.
Alopecia Areata
Demonstration of autoantibodies against tyrosine hydroxylase in patients with alopecia areata.
Epitopes, Avidity and IgG Subclasses of Tyrosine Hydroxylase Autoantibodies in Patients with Vitiligo and Alopecia Areata.
Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type I.
Alzheimer Disease
Allopregnanolone enhances the neurogenesis of midbrain dopaminergic neurons in APPswe/PSEN1 mice.
Alzheimer's Disease and Type 2 Diabetes Mellitus: The Link to Tyrosine Hydroxylase and Probable Nutritional Strategies.
Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase.
Cardiac sympathetic denervation and synucleinopathy in Alzheimer's disease with brain Lewy body disease.
Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease.
CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.
Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with Parkinson's, Alzheimer's with parkinsonism, and Alzheimer's disease.
Frequency analysis of catecholamine axonal morphology in human brain. II. Alzheimer's disease and hippocampal sympathetic ingrowth.
Immunocytochemical quantification of tyrosine hydroxylase at a cellular level in the mesencephalon of control subjects and patients with Parkinson's and Alzheimer's disease.
Nitration in neurodegeneration: deciphering the "Hows" "nYs".
Noggin Along with a Self-Assembling Peptide Nanofiber Containing Long Motif of Laminin Induces Tyrosine Hydroxylase Gene Expression.
Secretagogin expression in the vertebrate brainstem with focus on the noradrenergic system and implications for Alzheimer's disease.
Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer's disease.
Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brains of normal controls and patients with senile dementia of Alzheimer type.
Tyrosine hydroxylase-like (TH) immunoreactivity in Parkinson's disease and Alzheimer's disease.
Tyrosine hydroxylase-like immunoreactivity in senile plaques is not related to the density of tyrosine hydroxylase-positive fibers in patients with Alzheimer's disease.
[Catecholaminergic systems in the amygdaloid complex of SDAT and aged controls: tyrosine hydroxylase immunohistochemistry]
Amnesia
A comparison of the effects of localized brain administration of catecholamine and protein synthesis inhibitors on memory processing.
Role of the biogenic amines in the reversal of cycloheximide-induced amnesia.
Amyotrophic Lateral Sclerosis
Decrease of medullary catecholaminergic neurons in multiple system atrophy and Parkinson's disease and their preservation in amyotrophic lateral sclerosis.
Diminution of dopaminergic neurons in the substantia nigra of sporadic amyotrophic lateral sclerosis.
Nitration in neurodegeneration: deciphering the "Hows" "nYs".
Anemia
Recent progress in gene therapy for Parkinson's disease.
Anemia, Sickle Cell
Sympathetic Hyperactivity, Increased Tyrosine Hydroxylase and Exaggerated Corpus Cavernosum Relaxations Associated with Oxidative Stress Plays a Major Role in the Penis Dysfunction in Townes Sickle Cell Mouse.
Anhedonia
Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal.
[Signs of anhedonia and destructive changes in the ventral tegmental area of the midbrain in the model of the preclinical Parkinson's disease stage in experiment].
Anosmia
Temporary anosmia in mice following nasal lavage with dilute detergent solution.
Aortic Aneurysm, Abdominal
Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm: Impact on Inflammation, Oxidative Stress, and Vascular Remodeling.
Apnea
AMPK-?1 or AMPK-?2 Deletion in Smooth Muscles Does Not Affect the Hypoxic Ventilatory Response or Systemic Arterial Blood Pressure Regulation During Hypoxia.
Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.
aromatic-l-amino-acid decarboxylase deficiency
Pediatric neurotransmitter diseases.
The pediatric neurotransmitter disorders.
Arthritis
Changes in the density and distribution of sympathetic nerves in spleens from Lewis rats with adjuvant-induced arthritis suggest that an injury and sprouting response occurs.
Chronic arthritis increases tyrosine hydroxylase mRNA levels in the pontine noradrenergic cell groups.
Differences in the injury/sprouting response of splenic noradrenergic nerves in Lewis rats with adjuvant-induced arthritis compared with rats treated with 6-hydroxydopamine.
Tyrosine hydroxylase expression in CD4(+) T cells is associated with joint inflammatory alleviation in collagen type II-induced arthritis.
Arthritis, Experimental
Expression of tyrosine hydroxylase in CD4+ T cells contributes to alleviation of Th17/Treg imbalance in collagen-induced arthritis.
Intervention of Tyrosine Hydroxylase Expression Alters Joint Inflammation and Th17/Treg Imbalance in Collagen-Induced Arthritis.
[Changes in expression of tyrosine hydroxylase by CD4+ T lymphocytes in lymphoid tissues of DBA/1 mice with collagen-induced arthritis].
[Roles of tyrosine hydroxylase expressed by CD4+ T cell subsets in collagen type II-induced arthritis].
Arthritis, Rheumatoid
Norepinephrine from synovial tyrosine hydroxylase positive cells is a strong indicator of synovial inflammation in rheumatoid arthritis.
[Changes in expression of tyrosine hydroxylase by CD4+ T lymphocytes in lymphoid tissues of DBA/1 mice with collagen-induced arthritis].
Asthma
Exploring N1-p-Fluorobenzyl-Cymserine as an Inhibitor of 5-Lipoxygenase as a Candidate for Type 2 Diabetes and Neurodegenerative Disorder Treatment.
Ataxia
Abnormal expression of tyrosine hydroxylase immunoreactivity in Purkinje cells precedes the onset of ataxia in dilute-lethal mice.
Ectopic expression of tyrosine hydroxylase in Zebrin II immunoreactive Purkinje cells in the cerebellum of the ataxic mutant mouse, pogo.
Expression of tyrosine hydroxylase in cerebellar Purkinje cells of ataxic mutant mice: its relation to the onset and/or development of ataxia.
Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment.
The Neuroprotective Mechanism of Low-Frequency rTMS on Nigral Dopaminergic Neurons of Parkinson's Disease Model Mice.
Atrial Fibrillation
Expression of tyrosine hydroxylase and growth-associated protein 43 in aging atrial fibrillation patients of Xinjiang Uygur and Han nationality.
Increase of Autonomic Nerve Factors in Epicardial Ganglionated Plexi During Rapid Atrial Pacing Induced Acute Atrial Fibrillation.
Azoospermia
RT-qPCR for PHOX2B mRNA is a highly specific and sensitive method to assess neuroblastoma minimal residual disease in testicular tissue.
Basal Ganglia Diseases
6R-Tetrahydrobiopterin induces dopamine synthesis in a human neuroblastoma cell line, LA-N-1. A cellular model of DOPA-responsive dystonia.
Beckwith-Wiedemann Syndrome
Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism.
Blister
Production of catecholamines in the human epidermis.
Borna Disease
Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability.
Brain Diseases
A homozygous tyrosine hydroxylase gene promoter mutation in a patient with dopa-responsive encephalopathy: Clinical, biochemical and genetic analysis.
A New Tyrosine Hydroxylase Genotype Associated With Early-Onset Severe Encephalopathy.
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.
Brain MR patterns in inherited disorders of monoamine neurotransmitters: An analysis of 70 patients.
Compound heterozygous mutations in the TH gene in a Chinese family with autosomal-recessive dopa-responsive dystonia: A case report.
Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability.
New insights into the roles of microRNAs in drug addiction and neuroplasticity.
Novel mutations in the tyrosine hydroxylase gene in the first Czech patient with tyrosine hydroxylase deficiency.
Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia.
Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis.
Brain Diseases, Metabolic
CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.
Brain Injuries
Critical roles of astrocytic-CCL2-dependent monocyte infiltration in a DJ-1 knockout mouse model of delayed brain repair.
Hypoxia-ischemia induced neurological dysfunction and brain injury in the neonatal rat.
Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury.
Brain Injuries, Traumatic
Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury.
Enhanced catecholamine synthesis in the prefrontal cortex after traumatic brain injury: implications for prefrontal dysfunction.
Focal traumatic brain injury causes widespread reductions in rat brain norepinephrine turnover from 6 to 24 h.
Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury.
Traumatic Brain Injury Reduces Striatal Tyrosine Hydroxylase Activity and Potassium Evoked Dopamine Release in Rats.
Tyrosine hydroxylase, but not dopamine beta-hydroxylase, is increased in rat frontal cortex after traumatic brain injury.
Brain Ischemia
Resistance of hippocampal CA-1 noradrenergic fibers to five minutes of transient cerebral ischemia in the gerbil.
Time-dependent changes of vasoactive substances in rat cerebral ischemia.
Brain Neoplasms
Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4.
Preparation of Trojan horse liposomes (THLs) for gene transfer across the blood-brain barrier.
Breast Neoplasms
Correlation between tyrosine hydroxylase activity, melanogenesis, and estradiol binding in human melanoma cells.
Monoclonal anti-tyrosine hydroxylase antibodies.
Carcinogenesis
Antagonism by progesterone of diethylstilbestrol-induced pituitary tumorigenesis in Fischer 344 rats: effects on sex steroid receptors and tyrosine hydroxylase mRNA.
Mechanisms in progestin antagonism of pituitary tumorigenesis.
Polymer-encapsulated PC12 cells: long-term survival and associated reduction in lesion-induced rotational behavior.
Voltage-dependent ion channels in CAD cells: A catecholaminergic neuronal line that exhibits inducible differentiation.
Carcinoid Tumor
Adrenergic control of serotonin release from a midgut carcinoid tumour.
Increased dopamine production in patients with carcinoid tumors.
Carcinoma
Correlation between tyrosine hydroxylase activity, melanogenesis, and estradiol binding in human melanoma cells.
Effect of testosterone and 6-hydroxydopamine treatment on the metabolism of catecholamine and 5-hydroxytryptamine in methylcholanthrene-induced prostate carcinoma of rats.
Expression of chromogranin a protein and messenger RNA and tyrosine hydroxylase protein in paraffin-embedded sections of neuroendocrine neoplasms.
Monoclonal anti-tyrosine hydroxylase antibodies.
Carcinoma, Embryonal
Induction of Tyrosine Hydroxylase Gene Expression in Embryonal Carcinoma Stem Cells Using a Natural Tissue-Specific Inducer.
Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP.
Carcinoma, Hepatocellular
CDKN2 mutation is infrequent in german hepatocellular carcinoma.
Cardiomegaly
Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus.
Mechanisms of blood pressure variability-induced cardiac hypertrophy and dysfunction in mice with impaired baroreflex.
Cardiomyopathies
Increased gene expression of catecholamine-synthesizing enzymes in adrenal glands contributes to high circulating catecholamines in pigs with tachycardia-induced cardiomyopathy.
Cardiovascular Diseases
Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.
Histological study on the distribution of autonomic nerves in the human heart.
Tyrosine Hydroxylase Polymorphism (C-824T) and Hypertension: A Population-Based Study.
Catalepsy
Anti-inflammatory and Anti-oxidant Activity of Hidrox® in Rotenone-Induced Parkinson's Disease in Mice.
beta-Phenylethylamine reversal of chlorpromazine-induced activation of striatal tyrosine hydroxylase and catalepsy.
Effect of alpha-methyl-p-tyrosine on neuroleptic-induced catalepsy in rat.
Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects.
Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
On the role of storage granules in the functional utilization of newly synthesized dopamine.
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease.
Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson's Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions.
Chediak-Higashi Syndrome
Distinguishing between the catalytic potential and apparent expression of tyrosinase activities.
Cholangiocarcinoma
Increased local dopamine secretion has growth promoting effects in cholangiocarcinoma.
Cholera
A discrete dopaminergic projection from the incertohypothalamic A13 cell group to the dorsolateral periaqueductal gray in rat.
Brainstem dopaminergic, cholinergic and serotoninergic afferents to the pallidum in the squirrel monkey.
Catecholamine innervation of the piriform cortex: a tracing and immunohistochemical study in the rat.
Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease.
Distribution and innervation of putative arterial chemoreceptors in the bullfrog (Rana catesbeiana).
Distribution and ultrastructure of dopaminergic neurons in the dorsal motor nucleus of the vagus projecting to the stomach of the rat.
Dopaminergic and non-dopaminergic neurons in the ventral tegmental area of the rat project, respectively, to the cerebellar cortex and deep cerebellar nuclei.
GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus.
Glucocorticoids increase catecholamine synthesis and storage in PC12 pheochromocytoma cell cultures.
Immunohistochemical characterization of cardiac vagal preganglionic neurons in the rat.
Immunoreactivity for the NMDA NR1 subunit in bulbospinal catecholamine and serotonin neurons of rat ventral medulla.
Lower brainstem catecholamine afferents to the rat dorsal raphe nucleus.
Nerve growth factor and other agents mediate phosphorylation and activation of tyrosine hydroxylase. A convergence of multiple kinase activities.
Origin of noradrenergic afferents to the shell subregion of the nucleus accumbens: anterograde and retrograde tract-tracing studies in the rat.
Origin of the dopaminergic innervation of the rat dorsal raphe nucleus.
Projections to the alimentary canal from the dopaminergic neurons in the dorsal motor nucleus of the vagus of the rat.
Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells.
Regulation of nerve growth factor action on Nsp100 phosphorylation in PC12h cells by calcium.
Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction.
The hypothalamus and periaqueductal gray are the sources of dopamine fibers in the paraventricular nucleus of the thalamus in the rat.
The tungstate-stabilized tetramethylbenzidine reaction for light and electron microscopic immunocytochemistry and for revealing biocytin-filled neurons.
Tyrosine 3-monooxygenase regulates catecholamine synthesis in pheochromocytoma cells.
Tyrosine hydroxylase-immunoreactive cells in the nodose ganglion for the canine larynx.
Chorea
Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a.
Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea.
Choriocarcinoma
A factor(s) from a trophoblast cell line increases tyrosine hydroxylase activity in fetal hypothalamic cell cultures.
Serotonin-induced decrease in hypothalamic tyrosine hydroxylase activity and corresponding increase in prolactin release are abolished at midpregnancy and by transplants of rat choriocarcinoma cells.
Choroidal Effusions
Human orbital sympathetic nerve pathways.
Colitis
A role for interleukin 17A in IBD-related neuroplasticity.
Differential responses of intrinsic and extrinsic innervation of smooth muscle cells in rat colitis.
Electroacupuncture relieved visceral and referred hindpaw hypersensitivity in colitis rats by inhibiting tyrosine hydroxylase expression in the sixth lumbar dorsal root ganglia.
Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
Modulation of inflammatory response via alpha2-adrenoceptor blockade in acute murine colitis.
Coma
Brain monoamines in hepatic encephalopathy and other types of metabolic coma.
CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.
Craniocerebral Trauma
Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury.
Cystic Fibrosis
Neuropathy and vasculopathy in colonic strictures from children with cystic fibrosis.
Cystitis, Interstitial
Increased tyrosine hydroxylase immunoreactivity in bladder tissue from patients with classic and nonulcer interstitial cystitis.
Increased tyrosine hydroxylase immunoreactivity in the locus coeruleus of cats with interstitial cystitis.
Cysts
The neurotropic parasite Toxoplasma gondii increases dopamine metabolism.
Toxoplasma-induced changes in host risk behaviour are independent of parasite-derived AaaH2 tyrosine hydroxylase.
Deafness
Tyrosine hydroxylase in rat auditory midbrain: distribution and changes following deafness.
Decompression Sickness
Latent alterations in swimming behavior by developmental methylmercury exposure are modulated by the homolog of tyrosine hydroxylase in Caenorhabditis elegans.
Deglutition Disorders
Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia.
Dehydration
Alteration of dopaminergic innervation and voluntary movements after long period of thirst in a semi-desert rodent, Meriones shawi: Behavioral and immunohistochemical studies.
Pterin-4alpha-carbinolamine dehydratase in rat brain. I. Patterns of co-localization with tyrosine hydroxylase.
The role of dopamine in learning, memory, and performance of a water escape task.
[Interaction of neuronal NOS and catecholamines in regulation of expression of proteins of apoptosis by vasopressinergic hypothalamic neurons].
Delirium
Possible allelic association of a tyrosine hydroxylase polymorphism with vulnerability to alcohol-withdrawal delirium.
Short tandem repeat (STR) replacements in UTRs and introns suggest an important role for certain STRs in gene expression and disease.
Dementia
Degeneration of tyrosine hydroxylase-immunoreactive neurons in the cerebral cortex and hippocampus of patients with dementia with Lewy bodies.
Interaction between ?-synuclein and tau in Parkinson's disease Comment on Wills et al.: Elevated tauopathy and ?-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218.
Demyelinating Diseases
Neuropathology of Rett syndrome.
Dermatitis, Atopic
Increased number of immunoreactive nerve fibers in atopic dermatitis.
Diabetes Mellitus
Alzheimer's Disease and Type 2 Diabetes Mellitus: The Link to Tyrosine Hydroxylase and Probable Nutritional Strategies.
Factors influencing sweat gland innervation in diabetes.
Diabetes Mellitus, Type 1
Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population.
Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene.
Diabetes Mellitus, Type 2
Alzheimer's Disease and Type 2 Diabetes Mellitus: The Link to Tyrosine Hydroxylase and Probable Nutritional Strategies.
Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase.
Exploring N1-p-Fluorobenzyl-Cymserine as an Inhibitor of 5-Lipoxygenase as a Candidate for Type 2 Diabetes and Neurodegenerative Disorder Treatment.
Diabetic Coma
Brain monoamines in hepatic encephalopathy and other types of metabolic coma.
CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.
Diabetic Neuropathies
Effects of chronic experimental streptozotocin-induced diabetes on the noradrenergic and peptidergic innervation of the rat alimentary tract.
diacylglycerol kinase (atp) deficiency
Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus.
DiGeorge Syndrome
Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism.
Distemper
Inhibition of tyrosine hydroxylase expression within the substantia nigra of mice infected with canine distemper virus.
Diverticulitis
Altered enteric expression of the homeobox transcription factor Phox2b in patients with diverticular disease.
Dysautonomia, Familial
Tyrosine hydroxylase immunoreactivity in familial dysautonomia.
Dyskinesias
Anti-apoptotic effect of Shudipingchan granule in the substantia nigra of rat models of Parkinson's disease.
CaMKII inhibition ameliorated levodopa-induced dyskinesia by downregulating tyrosine hydroxylase activity in an experimental model of Parkinson's disease.
Ceftriaxone reduces L-dopa-induced dyskinesia severity in 6-hydroxydopamine parkinson's disease model.
Effects of repeated cyclosporin A administration on iminodipropionitrile-induced dyskinesia and TRE-/CRE-binding activities in rat brain.
l-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons.
Levodopa-induced dyskinesias in tyrosine hydroxylase deficiency.
Nurr1:RXR? heterodimer activation as monotherapy for Parkinson's disease.
Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease.
Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors.
Systemic administration of the propargylamine CGP 3466B prevents behavioural and morphological deficits in rats with 6-hydroxydopamine-induced lesions in the substantia nigra.
Dystonia
6R-Tetrahydrobiopterin induces dopamine synthesis in a human neuroblastoma cell line, LA-N-1. A cellular model of DOPA-responsive dystonia.
A case of late-onset dopa-responsive isolated dystonia secondary to a novel tyrosine hydroxylase gene variant.
A common point mutation in the tyrosine hydroxylase gene in autosomal recessive L-DOPA-responsive dystonia in the Dutch population.
A novel missense mutation pattern of the GCH1 gene in dopa-responsive dystonia.
A Novel Tyrosine Hydroxylase Variant in a Group of Chinese Patients with Dopa-Responsive Dystonia.
A Severe l-Dopa Responsive Dystonia With Slow and Continuous Improvement in a Patient With a Novel Mutation in the Tyrosine Hydroxylase Gene.
Brain biopterin and tyrosine hydroxylase in asymptomatic dopa-responsive dystonia.
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.
Comment on "Mild dopa-responsive dystonia in heterozygous tyrosine hydroxylase mutation carrier: Evidence of symptomatic enzyme deficiency?"
Compound heterozygous mutations in the TH gene in a Chinese family with autosomal-recessive dopa-responsive dystonia: A case report.
Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson's Disease and Dopa-Responsive Dystonia.
Dopa-responsive dystonia caused by tyrosine hydroxylase deficiency: Three cases report and literature review.
Dopa-responsive dystonia due to mild tyrosine hydroxylase deficiency.
Dopa-responsive dystonia simulating spastic paraplegia due to tyrosine hydroxylase (TH) gene mutations.
Dopa-responsive dystonia.
Dopa-responsive dystonia: [18F]dopa positron emission tomography.
Effects of mutations in tyrosine hydroxylase associated with progressive dystonia on the activity and stability of the protein.
Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in Dopa-responsive dystonia.
Genetics and biochemistry of dopa-responsive dystonia: significance of striatal tyrosine hydroxylase protein loss.
Genetics of primary dystonia.
GTP cyclohydrolase I and tyrosine hydroxylase gene mutations in familial and sporadic dopa-responsive dystonia patients.
GTP cyclohydrolase I gene, tetrahydrobiopterin, and tyrosine hydroxylase gene: their relations to dystonia and parkinsonism.
Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase.
Levodopa-responsive infantile parkinsonism due to a novel mutation in the tyrosine hydroxylase gene and exacerbation by viral infections.
Long-term course of L-dopa-responsive dystonia caused by tyrosine hydroxylase deficiency.
Low frequency of Parkin, Tyrosine Hydroxylase, and GTP Cyclohydrolase I gene mutations in a Danish population of early-onset Parkinson's Disease.
Mild dopa-responsive dystonia in heterozygous tyrosine hydroxylase mutation carrier: Evidence of symptomatic enzyme deficiency?
Mild dopa-responsive dystonia in heterozygous tyrosine hydroxylase mutation carrier: Evidence of symptomatic enzyme deficiency? Response from the authors.
Molecular genetics of hereditary dystonia--mutations in the GTP cyclohydrolase I gene.
Monoamine neurotransmitter deficiencies.
Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.
Mutations in the cyclic adenosine monophosphate response element of the tyrosine hydroxylase gene.
Mutations in the gene encoding epsilon-sarcoglycan cause myoclonus-dystonia syndrome.
Mutations in the tyrosine hydroxylase gene cause various forms of L-dopa-responsive dystonia.
Myoclonus-dystonia syndrome due to tyrosine hydroxylase deficiency.
Neuropathological Findings in Ephedrone Encephalopathy.
Novel mutations in the tyrosine hydroxylase gene in the first Czech patient with tyrosine hydroxylase deficiency.
Parkinsonism, dystonia, and hemiatrophy.
Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene.
Striatal biopterin and tyrosine hydroxylase protein reduction in dopa-responsive dystonia.
The effect of GTP cyclohydrolase-1 on tyrosine hydroxylase expression: implications in DOPA-responsive dystonia.
Tyrosine hydroxylase and levodopa responsive dystonia.
Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia.
Tyrosine hydroxylase deficiency presenting with a biphasic clinical course.
Tyrosine hydroxylase deficiency unresponsive to L-dopa treatment with unusual clinical and biochemical presentation.
Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis.
Tyrosine hydroxylase immunoreactivity and [3H]WIN 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia.
[Genetics of dystonia]
[Molecular biology of hereditary dystonia]
[Recessive dopa-responsive form of dystonia due to a mutation of the tyrosine hydroxylase gene]
[Tyrosine hydroxylase deficiency: a case of autosomal recessive dopa-responsive dystonia].
Dystonia Musculorum Deformans
Genetics of primary dystonia.
[Genetics of dystonia]
Ectodermal Dysplasia 1, Anhidrotic
Increased neurotrophic factor levels in ventral mesencephalic cultures do not explain the protective effect of osteopontin and the synthetic 15-mer RGD domain against MPP+ toxicity.
Eczema
Increased sensory neuropeptides in nodular prurigo: a quantitative immunohistochemical analysis.
Encephalitis
High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress.
Encephalomyelitis, Autoimmune, Experimental
Intraspinal nerve terminals immunoreactive for tyrosine hydroxylase, serotonin and substance P in guinea-pigs with acute experimental allergic encephalomyelitis.
Encephalomyelitis, Venezuelan Equine
Tyrosine hydroxylase activity in Venezuelan equine encephalomyelitis virus infection.
Endotoxemia
Effect of peripherally administered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice.
NF-kappaB inhibitors significantly attenuate the transcription of high affinity type-2 cationic amino acid transporter in LPS-stimulated rat kidney.
Epilepsy
Medullary tyrosine hydroxylase catecholaminergic neuronal populations in sudden unexpected death in epilepsy.
The activity of some neurotransmitter-synthetizing enzymes in experimental cobalt epilepsy.
The effectiveness of correcting abnormal metabolic profiles.
Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo.
Equine Infectious Anemia
Recent progress in gene therapy for Parkinson's disease.
Erectile Dysfunction
Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction.
Essential Hypertension
A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population.
Association analysis of two tyrosine hydroxylase gene polymorphisms in normotensive offspring from hypertensive families.
Decreased tyrosine hydroxylase activity in the adrenals of spontaneously hypertensive rats.
Effect of pyratrione (a tyrosine hydroxylase inhibitor) in essential hypertension.
Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension.
Vasopressin (VP) and neuropeptide FF (NPFF) systems in the normal and hypertensive human brainstem.
[Genetic polymorphism in tyrosine hydroxylase gene and essential hypertension in Hunan Han population.]
Esthesioneuroblastoma, Olfactory
Esthesioneuroblastoma: a nasal catecholamine-producing tumor of neural crest origin. Demonstration of tyrosine hydroxylase-immunoreactive tumor cells.
Fetal Growth Retardation
Chronic hypoxemia: effects on developing nitrergic and dopaminergic amacrine cells.
Fibrosarcoma
Activity of brain stem groups of catecholaminergic cells in tumor-bearing rats: response to immobilization stress.
Anthocyanins Promote Learning through Modulation of Synaptic Plasticity Related Proteins in an Animal Model of Ageing.
Brain response to induced peripheral cancer development in rats: dual fos-tyrosine hydroxylase and fos-oxytocin immunohistochemistry.
Ganglioglioma
Neurochemical profile of glioneuronal lesions from patients with pharmacoresistant focal epilepsies.
Neuroendocrine markers in central nervous system neuronal tumors (gangliocytoma and ganglioglioma).
The occurrence of catecholamine neurons in a parietal lobe ganglioglioma.
[The occurrence of tyrosine hydroxylase-immunoreactive neurons in a parietal lobe ganglioglioma]
Ganglion Cysts
Ganglions and ganglionic neurons in the cat's larynx.
[Effects of selective vegetative denervation on the urinary bladder of the adult rat]
[Morphological study of intra-laryngeal ganglia and their neurons in the cat]
Ganglioneuroblastoma
Real-time analysis of tyrosine hydroxylase gene expression: a sensitive and semiquantitative marker for minimal residual disease detection of neuroblastoma.
Ganglioneuroma
Neuroendocrine markers in central nervous system neuronal tumors (gangliocytoma and ganglioglioma).
Real-time analysis of tyrosine hydroxylase gene expression: a sensitive and semiquantitative marker for minimal residual disease detection of neuroblastoma.
Genetic Diseases, Inborn
Catecholamine biosynthesis and physiological regulation in neuroendocrine cells.
Glioblastoma
Evaluating Novel RXR Agonists That Induce ApoE and Tyrosine Hydroxylase in Cultured Human Glioblastoma Cells.
Human glioblastoma ADF cells express tyrosinase, L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea.
Glioma
Dopamine release modifies intracellular calcium levels in tyrosine hydroxylase-transfected C6 cells.
Gliosarcoma
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase.
gtp cyclohydrolase i deficiency
Diagnosing dopamine-responsive dystonias.
Dopa-responsive dystonia--clinical and genetic heterogeneity.
Hearing Loss, Noise-Induced
Activation of tyrosine hydroxylase in the lateral efferent terminals by sound conditioning.
Environmental enrichment to sound activates dopaminergic pathways in the auditory system.
The distribution and the modulation of tyrosine hydroxylase immunoreactivity in the lateral olivocochlear system of the guinea-pig.
Heart Diseases
Auricular tyrosine hydroxylase and dopamine-beta-hydroxylase activities and noradrenaline content in ischaemic heart disease.
Myocardial catecholamines and their biosynthetic enzymes in various human heart diseases.
Heart Failure
A possible change in the rate-limiting step for cardiac norepinephrine synthesis in the cardiomyopathic Syrian hamster.
ACE inhibition improves cardiac NE uptake and attenuates sympathetic nerve terminal abnormalities in heart failure.
Auricular tyrosine hydroxylase and dopamine-beta-hydroxylase activities and noradrenaline content in ischaemic heart disease.
Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure.
Effect of the changes of NMDA receptor in hypothalamic paraventricular nucleus on cardiac function and sympathetic nervous activity in rats with heart failure.
Is activation of the sympathetic nervous system beneficial or detrimental to the patient with chronic heart failure? Lessons learned from clinical trials with beta-adrenergic agonists and antagonists.
NF-?B in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure.
Reduced aortocoronary sinus extraction of epinephrine in patients with left ventricular failure secondary to long-term pressure or volume overload.
Reduction of cardiac tyrosine hydroxylase activity in experimental congestive heart failure. Its role in the depletion of cardiac norepinephrine stores.
Regulation of tissue noradrenaline in the rat myocardial infarction model of chronic heart failure.
The NADPH oxidase inhibitor apocynin improves cardiac sympathetic nerve terminal innervation and function in heart failure.
Heart Neoplasms
Functional Cardiac Paraganglioma Associated with a Rare SDHC Mutation.
Heart Septal Defects, Atrial
Auricular tyrosine hydroxylase and dopamine-beta-hydroxylase activities and noradrenaline content in ischaemic heart disease.
Heart Valve Diseases
Auricular tyrosine hydroxylase and dopamine-beta-hydroxylase activities and noradrenaline content in ischaemic heart disease.
Hepatic Encephalopathy
Brain monoamines in hepatic encephalopathy and other types of metabolic coma.
CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.
Hepatitis
Immunotherapy with a posttranscriptionally modified DNA vaccine induces complete protection against metastatic neuroblastoma.
Herpes Simplex
A herpes simplex virus-1 vector containing the rat tyrosine hydroxylase promoter directs cell type-specific expression of beta-galactosidase in cultured rat peripheral neurons.
Alteration in tyrosine hydroxylase, glutamic acid decarboxylase and choline acetyltransferase in basal ganglia following herpes simplex virus inoculation in rat neostriatum.
Alteration of tyrosine hydroxylase activity in PC12 cells infected with herpes simplex virus type 1.
An HSV-1 vector containing the rat tyrosine hydroxylase promoter enhances both long-term and cell type-specific expression in the midbrain.
An HSV-1 vector expressing tyrosine hydroxylase causes production and release of L-dopa from cultured rat striatal cells.
Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease.
Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector.
Differential regulation of the two neuronal nitric-oxide synthase gene promoters by the Oct-2 transcription factor.
Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival.
Isolation of an enhancer from the rat tyrosine hydroxylase promoter that supports long-term, neuronal-specific expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system.
Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase.
Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector.
Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain.
The Oct-2 transcription factor.
Two neurotropic viruses, herpes simplex virus type 1 and mouse hepatitis virus, spread along different neural pathways from the main olfactory bulb.
Tyrosine hydroxylase activity in the superior cervical ganglion during herpes simplex virus infection: correlation with viral titers and viral antigen.
Herpes Zoster
Aromatic L-amino acid decarboxylase- and tyrosine hydroxylase-immunohistochemistry in the adult human hypothalamus.
Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitary.
Contrasting effects of repeated treatment vs. withdrawal of methamphetamine on tyrosine hydroxylase messenger RNA levels in the ventral tegmental area and substantia nigra zona compacta of the rat brain.
Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus.
Dopamine is taken up from the circulation by, and released from, local noradrenergic varicose axon terminals in zona glomerulosa of the rat: a neurochemical and immunocytochemical study.
Effect of gonadal steroids and gamma-aminobutyric acid on LH release and dopamine expression and activity in the zona incerta in rats.
Effects of formaldehyde exposure on anxiety-like and depression-like behavior, cognition, central levels of glucocorticoid receptor and tyrosine hydroxylase in mice.
Hyperprolactinemia increases and hypoprolactinemia decreases tyrosine hydroxylase messenger ribonucleic acid levels in the arcuate nuclei, but not the substantia nigra or zona incerta.
Hypothalamic dopaminergic neurons in prolactin-deficient Ames dwarf mice: localization and quantification of deficit by tyrosine hydroxylase immunocytochemistry.
Ibotenic acid-induced neuronal degeneration: a morphological and neurochemical study.
In vivo voltammetric monitoring of noradrenaline release and catecholamine metabolism in the hypothalamic paraventricular nucleus.
Luteinizing hormone-releasing hormone and gamma-aminobutyric acid neurons in the medial preoptic area are synaptic targets of dopamine axons originating in anterior periventricular areas.
Neurotrophins and the neuroendocrine brain: different neurotrophins sustain anatomically and functionally segregated subsets of hypothalamic dopaminergic neurons.
Ontogenesis of tyrosine hydroxylase-immunopositive structures in the rat hypothalamus. An atlas of neuronal cell bodies.
Ontogeny of tyrosine hydroxylase mRNA signal levels in central dopaminergic neurons: development of a gender difference in the arcuate nuclei.
Origin and development of descending catecholaminergic pathways to the spinal cord in amphibians.
Peripheral administration of an angiotensin II AT(1) receptor antagonist decreases the hypothalamic-pituitary-adrenal response to isolation Stress.
Post mortem studies in Parkinson's disease--is it possible to detect brain areas for specific symptoms?
Postnatal regression of hypothalamic dopaminergic neurons in prolactin-deficient Snell dwarf mice.
Progesterone reverses the estradiol-induced decrease in tyrosine hydroxylase mRNA levels in the arcuate nucleus.
Rapid increase in LHRH mRNA levels following NMDA.
Reinnervation of dopamine neurons by regenerating serotonin axons in the rat medial zona incerta. A combined radioautographic and immunocytochemical ultrastructural study.
Sexually dimorphic expression of calcitonin gene-related peptide (CGRP) immunoreactivity by rat mediobasal hypothalamic neurons.
Stimulatory effect of human, but not bovine, growth hormone expression on numbers of tuberoinfundibular dopaminergic neurons in transgenic mice.
The dopaminergic system of the telencephalo-diencephalic areas of the vertebrate brain in the organization of the sleep-waking cycle.
The use of the MPTP-treated mouse as an animal model of parkinsonism.
Tyrosine hydroxylase mRNA in the neurons of the tuberoinfundibular region and zona incerta examined after gonadal steroid hormone treatment.
Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine Hydroxylase in Dopaminergic Neurons after Treatment with Paroxetine but Not with Agomelatine in Male Rats.
Hirschsprung Disease
Sympathetic neurotransmitter metabolism in Hirschsprung's disease.
Homocystinuria
The effectiveness of correcting abnormal metabolic profiles.
Huntington Disease
Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology.
The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea.
Hydatidiform Mole
Paternal uniparental isodisomy of tyrosine hydroxylase locus at chromosome 11p15.4: spectrum of phenotypical presentations simulating hydatidiform moles.
Hydrocephalus
Neuropathology and immunohistochemistry of the brain-stem in neonates with congenital hydrocephalus: comparative studies between aqueductal stenosis and Arnold-Chiari malformation.
Hyperaldosteronism
Hyperiodotyrosinemia-induced hyperprolactinemia and hyperaldosteronism.
Hyperalgesia
L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses.
Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models.
Hypercholesterolemia
Arginine uptake is attenuated, through post-translational regulation of cationic amino acid transporter-1, in hyperlipidemic rats.
Hyperglycemia
Effect of experimental diabetes on the catecholamine metabolism in rat brain.
Hyperkinesis
Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.
The hyperkinetic syndrome following long-term haloperidol treatment: involvement of dopamine and noradrenaline.
Hyperparathyroidism, Secondary
Effect of chronic renal failure with and without secondary hyperparathyroidism on the activities of synaptosomal tyrosine hydroxylase and monoamine oxidase.
Hyperprolactinemia
Cooperative Synthesis of Dopamine in Rat Mediobasal Hypothalamus as a Compensatory Mechanism in Hyperprolactinemia.
Effects of ovariectomy and hyperprolactinemia on tyrosine hydroxylase and dopamine-beta-hydroxylase activity in various limbic and hypothalamic structures.
Feedback regulation of PRL secretion is mediated by the transcription factor, signal transducer, and activator of transcription 5b.
Hyperiodotyrosinemia-induced hyperprolactinemia and hyperaldosteronism.
Hyperprolactinemia increases and hypoprolactinemia decreases tyrosine hydroxylase messenger ribonucleic acid levels in the arcuate nuclei, but not the substantia nigra or zona incerta.
Mass and in situ activity of tyrosine hydroxylase in the median eminence: effect of hyperprolactinemia.
Prolactin in cerebrospinal fluid: a probable site of prolactin autoregulation.
Tyrosine hydroxylase and POMC mRNA in the arcuate region are increased by castration and hyperprolactinemia.
Hypersensitivity
Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal.
Dopaminergic inhibition by G9a/Glp complex on tyrosine hydroxylase in nerve injury-induced hypersensitivity.
Electroacupuncture relieved visceral and referred hindpaw hypersensitivity in colitis rats by inhibiting tyrosine hydroxylase expression in the sixth lumbar dorsal root ganglia.
Exploring N1-p-Fluorobenzyl-Cymserine as an Inhibitor of 5-Lipoxygenase as a Candidate for Type 2 Diabetes and Neurodegenerative Disorder Treatment.
Hypophysectomy-induced striatal hypersensitivity and mesolimbic hyposensitivity to apomorphine.
The Neuroprotection of Low-Dose Morphine in Cellular and Animal Models of Parkinson's Disease Through Ameliorating Endoplasmic Reticulum (ER) Stress and Activating Autophagy.
Hypertension
A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase.
Adrenal and vascular tyrosine hydroxylase activity in Goldblatt hypertension.
Brain tyrosine hydroxylase activity and systolic blood pressure in rats treated with either deoxycorticosterone and salt or angiotensin.
Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats.
Comparison of neurons in rat medulla oblongata with fos immunoreactivity evoked by seizures, chemoreceptor, or baroreceptor stimulation.
Correction: Tyrosine Hydroxylase Is Short-Term Regulated by the Ubiquitin-Proteasome System in PC12 Cells and Hypothalamic and Brainstem Neurons from Spontaneously Hypertensive Rats: Possible Implications in Hypertension.
Decreased tyrosine hydroxylase activity in the adrenals of spontaneously hypertensive rats.
DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes: association with unexpected death from acute myocardial infarction and increased heart weight.
Effect of baroreceptor deafferentation on central catecholamines in the rat.
Effect of dietary NaCl on tyrosine hydroxylase in the superior cervical ganglia of Dahl rats.
Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.
Gender differences in hypothalamic tyrosine hydroxylase and alpha(2)-adrenoceptor subtype gene expression in cafeteria diet-induced hypertension and consequences of neonatal androgenization.
Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension.
Human Tyrosine Hydroxylase Natural Allelic Variation: Influence on Autonomic Function and Hypertension.
Influence of androgen on tyrosine hydroxylase mRNA in adrenal medulla of spontaneously hypertensive rats.
Intramedullary secretory gangliocytoma.
Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats.
Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension.
Nephrectomy-induced alterations in the synthesis of catecholamines in the sympathetic nervous system and central nervous system.
Norepinephrine-synthesizing enzymes in brain, adrenals and peripheral sympathetic nerves of spontaneously hypertensive rats.
Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension.
Quantitative immunofluorescence of tyrosine hydroxylase in the adrenal medulla of spontaneously hypertensive rats.
Quantitative immunohistochemical distributions of tyrosine hydroxylase and calmodulin in the brains of spontaneously hypertensive rats.
Regional changes in the activities of aminergic biosynthetic enzymes in the brains of hypertensive rats.
Role of endothelin receptor type A on catecholamine regulation in the olfactory bulb of DOCA-salt hypertensive rats: Hemodynamic implications.
Surgical management of pheochromocytoma with the use of metyrosine.
Sympathetic activation in adipose tissue and skeletal muscle of hypertensive rats.
Synthesis of catecholamines in the hypothalamus and brainstem in one-kidney, one clip and two-kidney, one clip hypertension in rabbits.
The Contribution of the C-824T Tyrosine Hydroxylase Polymorphism to the Prevalence of Hypertension in a South African Cohort: The SABPA Study.
The sympathetic nervous system: the muse of primary hypertension.
Time course analysis of tyrosine hydroxylase and angiotensinogen mRNA expression in central nervous system of rats submitted to experimental hypertension.
Tyrosine hydroxylase antisense gene therapy causes hypotensive effects in the spontaneously hypertensive rats.
Tyrosine hydroxylase is short-term regulated by the ubiquitin-proteasome system in PC12 cells and hypothalamic and brainstem neurons from spontaneously hypertensive rats: possible implications in hypertension.
Tyrosine Hydroxylase Polymorphism (C-824T) and Hypertension: A Population-Based Study.
Tyrosine hydroxylase regulation in the central nervous system.
Tyrosine hydroxylase: another piece of the genetics of hypertension puzzle.
Whole brain tyrosine hydroxylase activity during the development of deoxycorticosterone acetate-1% sodium chloride-induced hypertension in rats.
Hypertension, Pulmonary
Intrinsic cardiac adrenergic (ICA) cell density and MAO-A activity in failing rat hearts.
Hypertension, Renal
Gene expression of tyrosine hydroxylase and neuropeptide Y in prevertebral ganglia of renal hypertensive rats.
Hypertension, Renovascular
Adrenal and vascular tyrosine hydroxylase activity in Goldblatt hypertension.
Catecholamine synthesizing enzymes in brain stem and hypothalamus during the development of renovascular hypertension.
Changes in tyrosine hydroxylase and phenylethanolamine N-methyl transferase activity in individual brain nuclei during the development of renovascular hypertension in the rat [proceedings]
Increased hypothalamic noradrenergic activity in one-kidney, one-clip renovascular hypertensive rats.
Hypertensive Encephalopathy
CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.
Hyperthyroidism
Adrenal tyrosine hydroxylase activation in the developing rat: influence of the thyroid status.
Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat.
Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat.
Effects of apomorphine on behavioural activity and brain catecholamine synthesis in normal and L-triiodothyronine-treated rats.
Influence of neonatal and adult hyperthyroidism on behavior and biosynthetic capacity for norepinephrine, dopamine and 5-hydroxytryptamine in rat brain.
Thyroid hormone modulation of brain in vivo tyrosine hydroxylase activity and kinetics in the female catfish Heteropneustes fossilis.
Tyrosine hydroxylase activity and catecholamine content in the adrenals of young hypo- and hyperthyroid rats.
Hyperventilation
Activation of tyrosine hydroxylase in striatum of newborn piglets in response to hypocapnic ischemia and recovery.
Activity of tyrosine hydroxylase in the striatum of newborn piglets in response to hypocapnic hypoxia.
Hypoglycemia
Antecedent hypoglycemia, catecholamine depletion, and subsequent sympathetic neural responses.
Effect of experimental diabetes on the catecholamine metabolism in rat brain.
Effects of repetitive hypoglycemia on neuroendocrine response and brain tyrosine hydroxylase activity in the rat.
Glucoprivation by insulin leads to trans-synaptic increase in rat adrenal tyrosine hydroxylase mRNA levels.
Neonatal stress: effects of hypoglycemia and hypoxia on adrenal tyrosine hydroxylase gene expression.
Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis.
Posttranscriptional regulation of adrenal TH gene expression contributes to the maladaptive responses triggered by insulin-induced recurrent hypoglycemia.
Short- and long-term changes in adrenal tyrosine hydroxylase activity during insulin-induced hypoglycemia and cold stress.
Tyrosine hydroxylase activity and catecholamine biosynthesis in the adrenal medulla of rats during stress.
Hypokinesia
?-Methylphenylalanine exerts neuroprotective effects in a Parkinson's disease model by protecting against tyrosine hydroxylase depletion.
Absolute requirement of GDNF for adult catecholaminergic neuron survival.
Administration of AAV-Alpha Synuclein NAC Antibody Improves Locomotor Behavior in Rats Overexpressing Alpha Synuclein.
Compound heterozygous mutations in the TH gene in a Chinese family with autosomal-recessive dopa-responsive dystonia: A case report.
Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: evidence from calorie restriction intervention.
Gene disruption of caspase-3 prevents MPTP-induced Parkinson's disease in mice.
GFR ?-1 receptor expression in the aging nigrostriatal and mesoaccumbens pathways.
Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor.
Study on antrodia camphorata polysaccharide in alleviating the neuroethology of PD mice by decreasing the expression of NLRP3 inflammasome.
The effect of glucocorticoids on bradykinesia induced by immobilization stress.
Tyrosine hydroxylase deficiency with severe clinical course: clinical and biochemical investigations and optimization of therapy.
Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency.
[Tyrosine hydroxylase deficiency: a case of autosomal recessive dopa-responsive dystonia].
Hypotension
Catecholamines in turkeys with high or low blood pressure: effects of tyrosine hydroxylase inhibitor and ganglionic blocker.
Decrease in the reactivity of locus coeruleus neurons to hypotension after an increase in their tyrosine hydroxylase content: a subregional in vivo voltammetry study in the rat.
Effects of nitroprusside-induced hypotension on sympathetic nerve activity, tyrosine hydroxylase activity and [3H]norepinephrine uptake in rabbit vascular tissues.
Expression of Fos-like protein in brain following sustained hypertension and hypotension in conscious rabbits.
Hypotension and adrenal tyrosine hydroxylase in spontaneously hypertensive rats.
pSer40 tyrosine hydroxylase immunohistochemistry identifies the anatomical location of C1 neurons in rat RVLM that are activated by hypotension.
Serotonin(3) receptor stimulation in the nucleus tractus solitarii activates non-catecholaminergic neurons in the rat ventrolateral medulla.
Tyrosine hydroxylase activity and catecholamine biosynthesis in the adrenal medulla of rats during stress.
Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: a marker of activation following acute hypotension and glucoprivation.
Hypotension, Orthostatic
Catecholamine enzymes in the degenerative neurological disease idiopathic orthostatic hypotension.
Involvement of the ventrolateral medulla in parkinsonism with autonomic failure.
Hypothyroidism
Adrenal tyrosine hydroxylase activation in the developing rat: influence of the thyroid status.
Alterations in brain norepinephrine and tyrosine hydroxylase activity during experimental hypothyroidism in rats.
Effects of dysthyroidism on central catecholaminergic neurons.
Hypothyroidism increases prolactin secretion and decreases the intromission threshold for induction of pseudopregnancy in adult female rats.
Influence of hypothyroidism on the ontogenic development of tyrosine hydroxylase induction in the adrenal glands of the rat.
Influence of neonatal hypothyroidism on adrenal tyrosine hydroxylase activation in the young rat.
Influence of the thyroid hormone status on tyrosine hydroxylase in central and peripheral catecholaminergic structures.
Studies of the neural mechanisms by which hypothyroidism decreases prolactin secretion in the rat.
Tyrosine hydroxylase and dopamine beta-hydroxylase inductions evoked by reserpine in the superior cervical ganglion of developing eu- and hypothyroid rats.
Hypoventilation
Loss of catecholaminergic neurons in the medullary reticular formation in myotonic dystrophy.
Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.
Hypoxia-Ischemia, Brain
The pedunculopontine nucleus in developmental disorders of the basal ganglia.
Infarction, Middle Cerebral Artery
Colchicine affects cortical and amygdalar neurochemical changes differentially after middle cerebral artery occlusion in rats.
Neurochemical changes following occlusion of the middle cerebral artery in rats.
Infections
Alteration of tyrosine hydroxylase activity in PC12 cells infected with herpes simplex virus type 1.
Alterations in neurotransmitter-related enzyme activity in scrapie-infected PC12 cells.
An HSV-1 vector expressing tyrosine hydroxylase causes production and release of L-dopa from cultured rat striatal cells.
Behavioural Effect of Engineered Cells that Synthesize l-dopa or Dopamine after Grafting into the Rat Neostriatum.
Behavioural effects of genetically engineered cells releasing dopa and dopamine after intracerebral grafting in a rat model of Parkinson's disease.
Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells.
Close interactions between sympathetic neural fibres and follicular dendritic cells network are not altered in Peyer's patches and spleen of C57BL/6 mice during the preclinical stage of 139A scrapie infection.
Effect of Venezuelan equine encephalomyelitis virus infection on brain choline acetyltransferase and acetylcholinesterase activities.
Effects of pseudorabies virus on the neuronal properties of PC12 cells.
Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector.
Expression of rat tyrosine hydroxylase in insect tissue culture cells and purification and characterization of the cloned enzyme.
Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of ?-Synuclein in Mouse Brain.
In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatum.
Practical aspects of the development of ex vivo and in vivo gene therapy for Parkinson's disease.
Reference gene selection for normalization of PCR analysis in chicken embryo fibroblast infected with H5N1 AIV.
Reply to "reproducing increased dopamine with infection to evaluate the role of parasite-encoded tyrosine hydroxylase activity".
Reproducing increased dopamine with infection to evaluate the role of parasite-encoded tyrosine hydroxylase activity.
Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes.
RNAi-mediated silencing of HLA A2 suppressed acute rejection against human fibroblast xenografts in the striatum of 6-OHDA lesioned rats.
Tyrosine hydroxylase activity in the superior cervical ganglion during herpes simplex virus infection: correlation with viral titers and viral antigen.
Tyrosine hydroxylase activity in Venezuelan equine encephalomyelitis virus infection.
Influenza, Human
Depressed Hypoxic and Hypercapnic Ventilatory Responses at Early Stage of Lethal Avian Influenza A Virus Infection in Mice.
Lethal Avian Influenza A (H5N1) Virus Replicates in Pontomedullary Chemosensitive Neurons and Depresses Hypercapnic Ventilatory Response in Mice.
Insulin Resistance
Swimming exercise reduces preference for a high-fat diet by increasing insulin sensitivity in C57BL/6 mice.
Tyrosine hydroxylase gene microsatellite polymorphism associated with insulin resistance in depressive disorder.
Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease.
Intracranial Hemorrhages
Vasopressin (VP) and neuropeptide FF (NPFF) systems in the normal and hypertensive human brainstem.
Iron Deficiencies
The effect of chronic iron deficiency on adrenal tyrosine hydroxylase activity.
Iron Overload
Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra.
Ischemic Stroke
Exogenous glutathione exerts a therapeutic effect in ischemic stroke rats by interacting with intrastriatal dopamine.
Keratitis
Sensory and sympathetic nerve sprouting in the rat cornea following neonatal administration of capsaicin.
Kernicterus
Kernicterus: effect on choline acetyltransferase, glutamic acid decarboxylase and tyrosine hydroxylase activities in the brain of the Gunn rat.
The pedunculopontine nucleus in developmental disorders of the basal ganglia.
Kidney Failure, Chronic
Effect of chronic renal failure with and without secondary hyperparathyroidism on the activities of synaptosomal tyrosine hydroxylase and monoamine oxidase.
Leukemia
Cholinergic differentiation of rat sympathetic neurons in culture: effects of factors applied to distal neurites.
Coordinate regulation of choline acetyltransferase, tyrosine hydroxylase, and neuropeptide mRNAs by ciliary neurotrophic factor and leukemia inhibitory factor in cultured sympathetic neurons.
Cytokine-induced conversion of mesencephalic-derived progenitor cells into dopamine neurons.
Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease.
Involvement of leukemia inhibitory factor in the increases in galanin and vasoactive intestinal peptide mRNA and the decreases in neuropeptide Y and tyrosine hydroxylase mRNA in sympathetic neurons after axotomy.
Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells.
Neurotransmitters in Airway Parasympathetic Neurons Altered by NT-3 and Repeated Allergen Challenge.
No Evidence of Antibodies against GAD65 and Other Specific Antigens in Children with Autism.
Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes.
Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies.
Lewy Body Disease
(123)I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in ?-synucleinopathies.
Cardiac sympathetic denervation and synucleinopathy in Alzheimer's disease with brain Lewy body disease.
Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease.
Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease.
Reduced striatal tyrosine hydroxylase in incidental Lewy body disease.
Regional analysis and genetic association of nigrostriatal degeneration in Lewy body disease.
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies]
Lissencephaly
Neuropathology of the limbic system and brainstem in West syndrome.
Liver Cirrhosis
Brain monoamines in hepatic encephalopathy and other types of metabolic coma.
CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.
Liver Failure, Acute
Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachloride-intoxicated rats.
Long QT Syndrome
Localization of Romano-Ward long QT syndrome gene, LQT1, to the interval between tyrosine hydroxylase (TH) and D11S1349.
Lung Injury
Hypothermia attenuates iNOS, CAT-1, CAT-2, and nitric oxide expression in lungs of endotoxemic rats.
NF-kappaB involvement in the induction of high affinity CAT-2 in lipopolysaccharide-stimulated rat lungs.
Pulmonary transcription of CAT-2 and CAT-2B but not CAT-1 and CAT-2A were upregulated in hemorrhagic shock rats.
Lymphocytic Choriomeningitis
Regional tyrosine hydroxylase and choline acetyltransferase concentrations in the brains of lymphocytic choriomeningitis-infected mice.
Lymphoma
Analyses of novel prognostic factors in neuroblastoma patients.
Use of leptin-conjugated phosphatidic acid liposomes with resveratrol and epigallocatechin gallate to protect dopaminergic neurons against apoptosis for Parkinson's disease therapy.
Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies.
Lymphoma, B-Cell
Use of leptin-conjugated phosphatidic acid liposomes with resveratrol and epigallocatechin gallate to protect dopaminergic neurons against apoptosis for Parkinson's disease therapy.
Malnutrition
Prenatal malnutrition-induced functional alterations in callosal connections and in interhemispheric asymmetry in rats are prevented by reduction of noradrenaline synthesis during gestation.
Melanoma
Bone marrow-derived factors support growth of N-type, but not of melanocytic neuroblastoma cells.
Comparison of in vitro cytotoxicity of N-acetyl and N-propionyl derivatives of phenolic thioether amines in melanoma and neuroblastoma cells and the relationship to tyrosinase and tyrosine hydroxylase enzyme activity.
Correlation between tyrosine hydroxylase activity, melanogenesis, and estradiol binding in human melanoma cells.
Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?
Effect of penicillin-streptomycin and other antibiotics on melanogenic parameters in cultured B16/F10 melanoma cells.
Inability to demonstrate hydroxylation of tyrosine by murine melanoma "tyrosinase" (L-DOPA oxidase), using the tritiated water assay technique.
L-tyrosine, L-dopa, and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma cells.
Melanin formation in the inner ear is catalyzed by a new tyrosine hydroxylase kinetically and structurally different from tyrosinase.
Melanization stimulating activity in the skin of the gilthead porgy, Sparus auratus.
Melanocyte antigen-specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo.
Melanoma affine radiopharmaceuticals I. A comparative study of 131I-labeled quinoline and tyrosine derivatives.
Monoclonal anti-tyrosine hydroxylase antibodies.
Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment.
Pterin-dependent tyrosine hydroxylase mRNA is not expressed in human melanocytes or melanoma cells.
Purification of an autoantigenic 75-kDa human melanosomal glycoprotein.
Serum tyrosine hydroxylase activity is increased in melanoma patients. An ROC curve analysis.
Somatic cell hybrids producing inhibitors of melanotic melanoma tyrosine hydroxylase.
The association between Parkinson's disease and melanoma.
The inhibitory effect of DL-alpha-tocopheryl ferulate in lecithin on melanogenesis.
Tumor mRNA-transfected dendritic cells stimulate the generation of CTL that recognize neuroblastoma-associated antigens and kill tumor cells: immunotherapeutic implications.
Tyrosinase activity and isoenzyme distribution corresponding to growth and regression of melanoma in Sinclair miniature swine.
Melanoma, Experimental
Characteristics of tyrosinase in B16 melanoma.
Melanocyte stimulating hormone activation of tyrosinase in B16 mouse melanoma cells. Evidence for a differential induction of two distinct isoenzymes.
Tyrosinase isoenzymes in mammalian melanocytes. 2. Differential activation by alpha-melanocyte-stimulating hormone.
Melanosis
Use of tyrosine hydroxylase RNAi to study Megoura viciae (Hemiptera: Aphididae) sequestration of its host's l-DOPA for body melanism.
Memory Disorders
Enhanced catecholamine synthesis in the prefrontal cortex after traumatic brain injury: implications for prefrontal dysfunction.
Modulation of hippocampal dopamine and synapse-related proteins by electroacupuncture improves memory deficit caused by sleep deprivation.
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.
[Effect of dopamine receptor agonist apomorphine on scopolamine induced memory deficits in mice].
Menkes Kinky Hair Syndrome
Neurochemical and immunocytochemical studies of catecholamine system in the brindled mouse.
Metabolic Diseases
Bilateral subthalamic nucleus deep brain stimulation for dopa-responsive dystonia in a 6-year-old child.
Deficiency of tyrosine hydroxylase or tryptophan hydroxylase: a possible cause of two hypothetical metabolic diseases.
Metabolic Syndrome
Polymorphisms of genes for brain-derived neurotrophic factor, methylenetetrahydrofolate reductase, tyrosine hydroxylase, and endothelial nitric oxide synthase in depression and metabolic syndrome.
methenyltetrahydrofolate cyclohydrolase deficiency
Diagnosing dopamine-responsive dystonias.
Microcephaly
Morphometrical and microdensitometrical studies on peptide- and tyrosine hydroxylase-like immunoreactivities in the forebrain of rats prenatally exposed to methylazoxymethanol acetate.
Novel mutations in the tyrosine hydroxylase gene in the first Czech patient with tyrosine hydroxylase deficiency.
Microphthalmos
Immunohistochemical diagnosis of canine oral amelanotic melanocytic neoplasms.
Migraine Disorders
Anti-migraine and anti-depression activities of Tianshu capsule by mediating Monoamine oxidase.
Movement Disorders
A branch site mutation leading to aberrant splicing of the human tyrosine hydroxylase gene in a child with a severe extrapyramidal movement disorder.
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.
Ceftriaxone reduces L-dopa-induced dyskinesia severity in 6-hydroxydopamine parkinson's disease model.
Effects of pulmonary exposure to chemically-distinct welding fumes on neuroendocrine markers of toxicity.
IGF-1 inhibits MPTP/MPP+-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER.
Inhaled Hydrogen Sulfide Prevents Neurodegeneration and Movement Disorder in a Mouse Model of Parkinson's Disease.
Levodopa-induced dyskinesias in tyrosine hydroxylase deficiency.
Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson's disease model.
Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea.
Tyrosine hydroxylase deficiency presenting with a biphasic clinical course.
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies]
MPTP Poisoning
Discovery of novel and potent safinamide-based derivatives as highly selective hMAO-B inhibitors for treatment of Parkinson's disease (PD): Design, synthesis, in vitro, in vivo and in silico biological studies.
Indole-Substituted Benzothiazoles and Benzoxazoles as Selective and Reversible MAO-B Inhibitors for Treatment of Parkinson's Disease.
Multiple Endocrine Neoplasia
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes.
Multiple Endocrine Neoplasia Type 2a
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes.
Multiple Endocrine Neoplasia Type 2b
Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine.
Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra.
Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals.
Multiple Sclerosis
Catecholamine production and tyrosine hydroxylase expression in peripheral blood mononuclear cells from multiple sclerosis patients: effect of cell stimulation and possible relevance for activation-induced apoptosis.
Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis.
Multiple System Atrophy
Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease.
Decrease of medullary catecholaminergic neurons in multiple system atrophy and Parkinson's disease and their preservation in amyotrophic lateral sclerosis.
Involvement of the ventrolateral medulla in parkinsonism with autonomic failure.
Loss of DARPP-32 and calbindin in multiple system atrophy.
Muscle Hypotonia
Tyrosine hydroxylase deficiency with severe clinical course: clinical and biochemical investigations and optimization of therapy.
Muscle Rigidity
Involvement of cerulospinal glutamatergic neurotransmission in fentanyl-induced muscular rigidity in the rat.
Myocardial Infarction
DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes: association with unexpected death from acute myocardial infarction and increased heart weight.
Regulation of tissue noradrenaline in the rat myocardial infarction model of chronic heart failure.
Vasopressin (VP) and neuropeptide FF (NPFF) systems in the normal and hypertensive human brainstem.
Myocardial Ischemia
Inhibition of myocardial tyrosine hydroxylase during myocardial ischemia.
Myoclonus
Myoclonus-dystonia syndrome due to tyrosine hydroxylase deficiency.
Myopia
Pirenzepine Inhibits Myopia in Guinea Pig Model by Regulating the Balance of MMP-2 and TIMP-2 Expression and Increased Tyrosine Hydroxylase Levels.
Studies on retinal mechanisms possibly related to myopia inhibition by atropine in the chicken.
Transforming growth factor-beta in the chicken fundal layers: An immunohistochemical study.
Myxoma
Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroendocrine properties of tumors associated with Carney complex.
Neoplasm Metastasis
A rationally designed tyrosine hydroxylase DNA vaccine induces specific antineuroblastoma immunity.
Blood vessels in liver metastases from both sarcoma and carcinoma lack perivascular innervation and smooth muscle cells.
Comparison of two methods for evaluating bone marrow metastasis of neuroblastoma: Reverse transcription-polymerase chain reaction for tyrosine hydroxylase and magnetic resonance imaging.
Detection of tyrosine hydroxylase mRNA and minimal neuroblastoma cells by the reverse transcription-polymerase chain reaction.
Molecular mechanism of regulation of MTA1 by Granulocyte Colony Stimulating Factor.
Paragangliomas of the craniocervical region. An immunohistochemical study on tyrosine hydroxylase.
Plasma chromogranin A in pheochromocytoma, primary hyperparathyroidism and pituitary adenoma in comparison with catecholamine, parathyroid hormone and pituitary hormones.
Receptor activator of nuclear factor kappaB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly developed model of human neuroblastoma.
Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow.
The absence of autonomic perivascular nerves in human colorectal liver metastases.
[A long survived case of malignant pheochromocytoma treated with alpha-methyl-p-tyrosine and midaglizol (DG-5128)]
[Supersensitive detection of tyrosine hydroxylase mRNA and neuroblastoma cells by reverse transcription and polymerase chain reaction]
Neoplasm Micrometastasis
Receptor activator of nuclear factor kappaB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly developed model of human neuroblastoma.
[Molecular diagnostic detection of circulating tumor cells and their prognostic implications]
Neoplasm, Residual
Expression of Wilms tumor gene in high risk neuroblastoma: complementary marker to tyrosine hydroxylase for detection of minimal residual disease.
Impact of Minimal Residual Disease Detection Prior to Autologous Stem Cell Transplantation for Post-transplant Outcome in High Risk Neuroblastoma.
Minimal residual disease at the time of peripheral blood stem cell harvest in patients with advanced neuroblastoma.
Minimal residual disease in peripheral blood stem cell harvests from high-risk neuroblastoma patients.
Molecular assessment of minimal residual disease in PBSC harvests provides prognostic information in neuroblastoma.
New splicing variants for human Tyrosine Hydroxylase gene with possible implications for the detection of minimal residual disease in patients with neuroblastoma.
Real-time analysis of tyrosine hydroxylase gene expression: a sensitive and semiquantitative marker for minimal residual disease detection of neuroblastoma.
Useful markers for detecting minimal residual disease in cases of neuroblastoma.
Usefulness of tyrosine hydroxylase mRNA for diagnosis and detection of minimal residual disease in neuroblastoma.
Neoplasms
A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies.
A nonsecreting pheochromocytoma presenting as an incidental adrenal mass. Report on a case.
Acetylcholine synthesis in sympathetic human neuroblastoma.
Activity of brain stem groups of catecholaminergic cells in tumor-bearing rats: response to immobilization stress.
Alzheimer`s disease-like early-phase brain pathogenesis: Self-curing amelioration of neurodegeneration from pro-inflammatory 'wounding' to anti-inflammatory 'healing'.
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
Analyses of novel prognostic factors in neuroblastoma patients.
Association of tyrosine hydroxylase expression in brain and tumor with increased tumor growth in sympathectomized mice.
Biochemical activity in the metastatic lesions of neuroblastoma.
Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene.
Blockade of TLR4 Within the Paraventricular Nucleus Attenuates Blood Pressure by Regulating ROS and Inflammatory Cytokines in Prehypertensive Rats.
Brain response to induced peripheral cancer development in rats: dual fos-tyrosine hydroxylase and fos-oxytocin immunohistochemistry.
Catecholamine metabolism in neuroblastoma.
Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.
Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumours.
Characteristics of tyrosinase in B16 melanoma.
Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model.
Co-expression of IL-15 enhances anti-neuroblastoma effectivity of a tyrosine hydroxylase-directed DNA vaccination in mice.
Composite pheochromocytoma/ganglioneuroma of the adrenal gland associated with multiple endocrine neoplasia 2A: case report with immunohistochemical analysis.
Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model.
Considerations for the Use of SH-SY5Y Neuroblastoma Cells in Neurobiology.
Correlation between tyrosine hydroxylase immunoreactive cells in tumors and urinary catecholamine output in neuroblastoma patients.
Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.
Cytogenetic and immunohistochemical analysis of an adult anaplastic neuroblastoma.
Deficiency of Phenylethanolamine N-Methyltransferase in Norepinephrine-Producing Pheochromocytoma.
Detection of neuroblastoma cells in blood by reverse transcriptase-polymerase chain reaction.
Detection of neuroblastoma cells in bone marrow and peripheral blood at diagnosis by the reverse transcriptase-polymerase chain reaction for tyrosine hydroxylase mRNA.
Development of colonic and pancreatic endocrine tumours in mice expressing a glucagon-SV40 T antigen transgene.
Diagnostic identification of malignant cells in the cerebrospinal fluid by tumor-specific qRT-PCR.
Disease outcome may be predicted by molecular detection of minimal residual disease in bone marrow in advanced neuroblastoma: a pilot study.
Distinct morphological and immunohistochemical features and different growth rates among four human neuroblastomas heterotransplanted into nude mice.
DL?3?n?butylphthalide reduces microglial activation in lipopolysaccharide?induced Parkinson's disease model mice.
Dopamine, norepinephrine and serotonin production by an intestinal carcinoid tumor.
Dopamine-secreting glomus vagale: a case report and histopathologic correlation.
Dopamine-Secreting Paraganglioma in the Retroperitoneum.
Downregulation of miR-21 suppresses 1-methyl-4-phenylpyridinium-induced neuronal damage in MES23.5 cells.
Dynamics of cell proliferation and cell death during the emergence of primitive neuroectodermal tumors of the immature central nervous system in transgenic mice.
Early clinical evaluation of neuroblastoma cell detection by reverse transcriptase-polymerase chain reaction (RT-PCR) for tyrosine hydroxylase mRNA.
Effect of testosterone and 6-hydroxydopamine treatment on the metabolism of catecholamine and 5-hydroxytryptamine in methylcholanthrene-induced prostate carcinoma of rats.
Effects of Nogo-A Silencing on TNF-? and IL-6 Secretion and TH Downregulation in Lipopolysaccharide-Stimulated PC12 Cells.
Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: preclinical assessment and application to bone marrow samples from neuroblastoma patients.
Elevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGF?1, and TNF? associated with high-altitude pulmonary edema in an Indian population.
Enhanced immunohistochemical detection of autonomic nerve fibers, cytokines and inducible nitric oxide synthase by light and fluorescent microscopy in rat spleen.
Evidence of chromaffin oxygen sensing in neuroblastoma.
Expression of chromogranin a protein and messenger RNA and tyrosine hydroxylase protein in paraffin-embedded sections of neuroendocrine neoplasms.
Expression of mRNA coding for four catecholamine-synthesizing enzymes in human adrenal pheochromocytomas.
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Extraadrenal paragangliomas. An immunocytochemical and ultrastructural report.
Functional Cardiac Paraganglioma Associated with a Rare SDHC Mutation.
G-CSF reduces loss of dopaminergic neurons by inhibiting TNF-? and IL-1? in mouse model of Parkinson's disease.
Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.
Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly.
Growth of human pheochromocytomas in the anterior eye chamber of the rat. A histochemical study on amine and peptide content of pheochromocytoma tumour cells.
High-density marker analysis of 11p15.5 in non-small cell lung carcinomas reveals allelic deletion of one shared and one distinct region when compared to breast carcinomas.
HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors.
Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease.
Hypertension and a tumor of the glomus jugulare region. Evidence for epinephrine biosynthesis.
ICV vs. VMH injection of leptin: comparative effects on hypothalamic gene expression.
Immunohistochemical and morphological characterization of spontaneously occurring pheochromocytomas in the aging mouse.
Immunotherapy with a posttranscriptionally modified DNA vaccine induces complete protection against metastatic neuroblastoma.
In vitro translation of mRNA from rat pheochromocytoma tumors, characterization of tyrosine hydroxylase.
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent.
Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma.
Interleukin-1 beta and tumor necrosis factor-alpha stimulate the cat-2 gene of the L-arginine transporter in cultured vascular smooth muscle cells.
Intramedullary secretory gangliocytoma.
Intraoperative hypertensive crisis due to a catecholamine-secreting esthesioneuroblastoma.
Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model.
Large cell neuroblastoma: a distinct phenotype of neuroblastoma with aggressive clinical behavior.
MEN2 Syndrome-Related Medullary Thyroid Carcinoma with Focal Tyrosine Hydroxylase Expression: Does It Represent a Hybrid Cellular Phenotype or Functional State of Tumor Cells?
Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice.
Molecular detection of dopamine decarboxylase expression by means of reverse transcriptase and polymerase chain reaction in bone marrow and peripheral blood: utility as a tumor marker for neuroblastoma.
Molecular monitoring of tumor cell contamination in leukapheresis products from stage IV neuroblastoma patients before and after positive CD34 selection.
Monoamine oxidase a down-regulation contributes to high metanephrine concentration in pheochromocytoma.
Multi-antigen DNA vaccine delivered by polyethylenimine and Salmonella enterica in neuroblastoma mouse model.
Neuroblastoma initially presenting as a primary bone tumor: diagnostic value of molecular assays for tyrosine hydroxylase.
Neuroendocrine characteristics of human Leydig cell tumours.
Neuroendocrine markers in central nervous system neuronal tumors (gangliocytoma and ganglioglioma).
Neurogenic and anti-inflammatory effects of probiotics in Parkinson's disease: A systematic review of preclinical and clinical evidence.
Neuromodulatory complement of the pericardial organs in the embryonic lobster, Homarus americanus.
Neuronal and glial markers in tumours of neuroblastic origin.
Neurotransmitter analysis of dermal neurofibromas: implications for the pathogenesis and treatment of neurofibromatosis.
New splicing variants for human Tyrosine Hydroxylase gene with possible implications for the detection of minimal residual disease in patients with neuroblastoma.
No Evidence of Antibodies against GAD65 and Other Specific Antigens in Children with Autism.
Oncocytic adrenocortical neoplasms: a report of seven cases and review of the literature.
Outcome prediction by molecular detection of minimal residual disease in bone marrow for advanced neuroblastoma.
Peripheral carcinoid tumor of the lung with focal melanin production.
Peripheral neuroepithelioma (peripheral primitive neuroectodermal tumor) of the uterine cervix.
Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes.
Phosphorylation of tyrosine hydroxylase on at least three sites in rat pheochromocytoma PC12 cells treated with 56 mM K+: determination of the sites on tyrosine hydroxylase phosphorylated by cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases.
Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease.
Pilot study to evaluate MYCN expression as a neuroblastoma cell marker to detect minimal residual disease by RT-PCR.
Pinocembrin Decreases Ventricular Fibrillation Susceptibility in a Rat Model of Depression.
Plasma chromogranin A in pheochromocytoma, primary hyperparathyroidism and pituitary adenoma in comparison with catecholamine, parathyroid hormone and pituitary hormones.
Polyoma-induced neoplasms of the mouse adrenal medulla. Characterization of the tumors and establishment of cell lines.
Primary paraganglioma of the thyroid gland.
Prognostic impact of the detection of microcirculating tumor cells by a real-time RT-PCR assay of tyrosine hydroxylase in patients with advanced neuroblastoma.
Purification and characterization of the blue-green rat phaeochromocytoma (PC12) tyrosine hydroxylase with a dopamine-Fe(III) complex. Reversal of the endogenous feedback inhibition by phosphorylation of serine-40.
Purification of tyrosine hydroxylase from pheochromocytoma tumors.
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
Real-time RT-PCR of tyrosine hydroxylase to detect bone marrow involvement in advanced neuroblastoma.
Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors.
Sequential detection of tumor cells in the peripheral blood and bone marrow of patients with stage IV neuroblastoma by the reverse transcription-polymerase chain reaction for tyrosine hydroxylase mRNA.
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
Solid-pseudopapillary tumor of the pancreas: its origin revisited.
Studies on tyrosine hydroxylase in neuroblastoma in relation to urinary levels of catecholamine metabolites.
Sympathectomy reduces tumor weight and affects expression of tumor-related genes in melanoma tissue in the mouse.
Sympathetic innervation, norepinephrine content, and norepinephrine turnover in orthotopic and spontaneous models of breast cancer.
Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroendocrine properties of tumors associated with Carney complex.
Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow.
The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells.
The pyloric neural circuit of the herbivorous crab Pugettia producta shows limited sensitivity to several neuromodulators that elicit robust effects in more opportunistically feeding decapods.
Two cases of duodenal gangliocytic paraganglioma: immunocytochemical characteristics.
Tyrosine hydroxylase activity in a transplantable islet cell tumour of golden hamster.
Tyrosine hydroxylase activity in human adrenals and tumours of the neural crest.
Tyrosine hydroxylase, interleukin-1beta and tumor necrosis factor-alpha are overexpressed in peripheral blood mononuclear cells from schizophrenia patients as determined by semi-quantitative analysis.
Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies.
Utility of Phox2b immunohistochemical stain in neural crest tumours and non-neural crest tumours in paediatric patients.
Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action.
[Expression of mRNAs coding for catecholamine synthesizing enzymes in human adrenal pheochromocytoma]
[The mRNA expression levels of IL-1beta, TNF-alpha and tyrosine hydroxylase in peripheral blood of paranoid schizophrenic patients]
Nervous System Diseases
Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging.
CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.
Dopamine D3 receptor is decreased and D2 receptor is elevated in the striatum of Parkinson's disease.
G-Quadruplex-Enabling Sequence within the Human Tyrosine Hydroxylase Promoter Differentially Regulates Transcription.
Lower nucleus accumbens ?-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours.
Transgenic mice expressing yellow fluorescent protein under control of the human tyrosine hydroxylase promoter.
[Tyrosine hydroxylase in the catecholamine neurons of the autopsy brains with degenerative neurological disorder]
Neuralgia
Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain.
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.
Neuritis
[Role p53 and MAPK signaling integration in the regulation of PC12 cell neural differentiation].
Neuroblastoma
3,4-dihydroxyphenylalanine (dopa) metabolism and retinoic acid induced differentiation in human neuroblastoma.
6R-Tetrahydrobiopterin induces dopamine synthesis in a human neuroblastoma cell line, LA-N-1. A cellular model of DOPA-responsive dystonia.
A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies.
A neuroblastoma-selective suicide gene therapy approach using the tyrosine hydroxylase promoter.
A rationally designed tyrosine hydroxylase DNA vaccine induces specific antineuroblastoma immunity.
A simple PCR method for rapid genotype analysis of the TH-MYCN transgenic mouse.
Acetylcholine synthesis in sympathetic human neuroblastoma.
Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore.
Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line.
AP1-mediated transcriptional enhancement of the rat tyrosine hydroxylase gene by muscarinic stimulation.
Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH.
Ayurvedic (science of life) agents induce differentiation in murine neuroblastoma cells in culture.
Biochemical properties of monoamine-rich human neuroblastoma cells.
Bone marrow non-mesenchymal mononuclear cells induce functional differentiation of neuroblastoma cells.
Bone marrow-derived factors support growth of N-type, but not of melanocytic neuroblastoma cells.
Catecholamine metabolism in neuroblastoma.
Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.
Changes in expression of tyrosine hydroxylase immunoreactivity in human SMS-KCNR neuroblastoma following retinoic acid or phorbol ester-induced differentiation.
Ciliary neurotrophic factor suppresses Phox2a in sympathetic neurons.
Circulating neuroblastoma cells detected by reverse transcriptase polymerase chain reaction for tyrosine hydroxylase mRNA are an independent poor prognostic indicator in stage 4 neuroblastoma in children over 1 year.
Clinical Significance of Tyrosine Hydroxylase mRNA Transcripts in Peripheral Blood at Diagnosis in Patients with Neuroblastoma.
Comparison of immunocytochemistry, real-time quantitative RT-PCR and flow cytometry for detection of minimal residual disease in neuroblastoma.
Comparison of in vitro cytotoxicity of N-acetyl and N-propionyl derivatives of phenolic thioether amines in melanoma and neuroblastoma cells and the relationship to tyrosinase and tyrosine hydroxylase enzyme activity.
Comparison of two methods for evaluating bone marrow metastasis of neuroblastoma: Reverse transcription-polymerase chain reaction for tyrosine hydroxylase and magnetic resonance imaging.
Concomitant elevation of tyrosine hydroxylase and dopamine beta-hydroxylase by cyclic AMP in cultured mouse neuroblastoma cells.
Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model.
Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR: recommendations by the International Neuroblastoma Risk Group Task Force.
Correlation between tyrosine hydroxylase immunoreactive cells in tumors and urinary catecholamine output in neuroblastoma patients.
Detection of micrometastasis of neuroblastoma to bone marrow and tumor dissemination to hematopoietic autografts using flow cytometry and reverse transcriptase-polymerase chain reaction.
Detection of multiple hormones and their mRNAs in human neuroblastoma cell line NB-1 using in situ hybridization, immunocytochemistry and radioimmunoassay.
Detection of neuroblastoma cells during clinical follow up: advanced flow cytometry and rt-PCR for tyrosine hydroxylase using both conventional and real-time PCR.
Detection of neuroblastoma cells in bone marrow and peripheral blood at diagnosis by the reverse transcriptase-polymerase chain reaction for tyrosine hydroxylase mRNA.
Detection of neuroblastoma cells in bone marrow and peripheral blood by different techniques: accuracy and relationship with clinical features of patients.
Detection of neuroblastoma cells in CD34+ selected peripheral stem cells using a combination of tyrosine hydroxylase nested RT-PCR and anti-ganglioside GD2 immunocytochemistry.
Detection of the PGP9.5 and tyrosine hydroxylase mRNAs for minimal residual neuroblastoma cells in bone marrow and peripheral blood.
Detection of tyrosine hydroxylase mRNA and minimal neuroblastoma cells by the reverse transcription-polymerase chain reaction.
Detection procedures for neuroblastoma cells metastatic to blood and bone marrow: blinded comparison of chromogranin A heminested reverse transcription polymerase chain reaction to tyrosine hydroxylase nested reverse transcription polymerase chain reaction and to anti-GD2 immunocytology.
Developmental gene expression of sympathetic nervous system tumors reflects their histogenesis.
Diagnostic identification of malignant cells in the cerebrospinal fluid by tumor-specific qRT-PCR.
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells.
Differential Expression of Tyrosine Hydroxylase Protein and Apoptosis-Related Genes in Differentiated and Undifferentiated SH-SY5Y Neuroblastoma Cells Treated with MPP(.).
Differential regulation of phenotypic expression in a pluripotential neuroblastoma cell line.
Differentiated dopaminergic MN9D cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons.
Disease outcome may be predicted by molecular detection of minimal residual disease in bone marrow in advanced neuroblastoma: a pilot study.
DNA minigene vaccination for adjuvant neuroblastoma therapy.
Dopa-release from mouse neuroblastoma clone N 1 E-115 into the culture medium. A test for tyrosine hydroxylase activity.
Early clinical evaluation of neuroblastoma cell detection by reverse transcriptase-polymerase chain reaction (RT-PCR) for tyrosine hydroxylase mRNA.
Effect of carbachol and 56 mm-potassium chloride on the cyclic AMP-mediated induction of tyrosine hydroxylase in neuroblastoma cells in culture.
Effects of desipramine treatment on tyrosine hydroxylase gene expression in cultured neuroblastoma cells and rat brain tissue.
Effects of serotonin on tyrosine hydroxylase and tau protein in a human neuroblastoma cell line.
Estrogen modulation of catecholamine synthesis and monoamine oxidase A activity in the human neuroblastoma cell line SK-ER3.
Estrogens influence growth, maturation, and amyloid beta-peptide production in neuroblastoma cells and in a beta-APP transfected kidney 293 cell line.
Ethanol increases tyrosine hydroxylase gene expression in N1E-115 neuroblastoma cells.
Evaluation of neurotropic drug actions on tyrosine hydroxylase activity and dopamine metabolism in clonal cell lines.
Event-free survival of infants and toddlers enrolled in the HR-NBL-1/SIOPEN trial is associated with the level of neuroblastoma mRNAs at diagnosis.
Evidence of chromaffin oxygen sensing in neuroblastoma.
Ex vivo expansion of autologous PB CD34+ cells provides a purging effect in children with neuroblastoma.
Ex vivo expansion of CD34+/CD41+ late progenitors from enriched peripheral blood CD34+ cells.
Expression of mRNAs for PACAP and its receptor in human neuroblastomas and their relationship to catecholamine synthesis.
Expression of Tyrosine Hydroxylase Increases the Resistance of Human Neuroblastoma Cells to Oxidative Insults.
Expression of Wilms tumor gene in high risk neuroblastoma: complementary marker to tyrosine hydroxylase for detection of minimal residual disease.
Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.
Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma.
Ginsenoside Re protects methamphetamine-induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C ? in human neuroblastoma dopaminergic SH-SY5Y cell lines.
Glial cell line-derived neurotrophic factor up-regulates the expression of tyrosine hydroxylase gene in human neuroblastoma cell lines.
Glucocorticoids increase tyrosine hydroxylase activity in cultured murine neuroblastoma.
Human neuroblastoma cells transfected with tyrosine hydroxylase gain increased resistance to methylmercury-induced cell death.
Improving Detection of Metastatic Neuroblastoma in Bone Marrow Core Biopsies: A Proposed Immunohistochemical Approach.
Induction of cholinergic and adrenergic differentiation in N-18 cells by differentiation agents and DNA demethylating agents.
Induction of tyrosine hydroxylase and dopamine beta-hydroxylase in cultured mouse neuroblastoma by 8Br-cAMP. Involvement of RNA and protein synthesis.
Induction of tyrosine hydroxylase by glucocorticoids in mouse neuroblastoma cells. Enhancement of the induction by cyclic AMP.
Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma.
Inhibition of catecholamine biosynthesis by carbidopa and metyrosine in neuroblastoma.
Inhibition of striatal tyrosine hydroxylase by low concentrations of apomorphine.
Intracellular redistribution of neuropeptides and secretory proteins during differentiation of neuronal cell lines.
L-DOPA and glia-conditioned medium have additive effects on tyrosine hydroxylase expression in human catecholamine-rich neuroblastoma NB69 cells.
Long-term results of CD34(+) cell transplantation in children with neuroblastoma.
Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP.
Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma.
Measurement of tyrosine hydroxylase transcripts in bone marrow using biopsied tissue instead of aspirates for neuroblastoma.
Mechanisms of ascorbic acid stimulation of norepinephrine synthesis in neuronal cells.
Minimal residual disease at the time of peripheral blood stem cell harvest in patients with advanced neuroblastoma.
Minimal residual disease in peripheral blood stem cell harvests from high-risk neuroblastoma patients.
Modulation of frequency and duration of repetitive magnetic stimulation affects catecholamine levels and tyrosine hydroxylase activity in human neuroblastoma cells: implication for the antidepressant effect of rTMS.
Modulation of tyrosine hydroxylase expression by melatonin in human SH-SY5Y neuroblastoma cells.
Molecular assessment of minimal residual disease in PBSC harvests provides prognostic information in neuroblastoma.
Molecular detection of tyrosine hydroxylase in the peripheral blood of patients with neuroblastoma: useful at diagnosis but not predictive of subsequent relapse during off-therapy follow-up.
Molecular monitoring of tumor cell contamination in leukapheresis products from stage IV neuroblastoma patients before and after positive CD34 selection.
Mouse neuroblastoma clone N1E-115: a suitable model for studying the action of dopamine agonists of tyrosine hydroxylase activity.
mRNAs of tyrosine hydroxylase and dopa decarboxylase but not of GD2 synthase are specific for neuroblastoma minimal disease and predicts outcome for children with high-risk disease when measured at diagnosis.
Multiple forms of tyrosine hydroxylase in human neuroblastoma cells: quantitation with isoform-specific antibodies.
Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.
Neuroblastoma cell detection by reverse transcriptase-polymerase chain reaction (RT-PCR) for tyrosine hydroxylase mRNA.
Neuroblastoma directed therapy by a rational prodrug design of etoposide as a substrate for tyrosine hydroxylase.
Neuroblastoma initially presenting as a primary bone tumor: diagnostic value of molecular assays for tyrosine hydroxylase.
Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours.
Neuronal properties of hybrid neuroblastoma X sympathetic ganglion cells.
New splicing variants for human Tyrosine Hydroxylase gene with possible implications for the detection of minimal residual disease in patients with neuroblastoma.
Nitric oxide induces differentiation in the NB69 human catecholamine-rich cell line.
Outcome prediction by molecular detection of minimal residual disease in bone marrow for advanced neuroblastoma.
Peripheral blood stem cell tumor cell contamination and survival of neuroblastoma patients.
Pitfalls in detection of contaminating neuroblastoma cells by tyrosine hydroxylase RT-PCR due to catecholamine-producing hematopoietic cells.
Potential application of ELAVL4 real-time quantitative reverse transcription-PCR for detection of disseminated neuroblastoma cells.
Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-?B Signaling.
Prognostic impact of the detection of microcirculating tumor cells by a real-time RT-PCR assay of tyrosine hydroxylase in patients with advanced neuroblastoma.
Properties of tyrosine hydroxylation in living mouse neuroblastoma clone N1E-115.
Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP-treated human neuroblastoma cells with melatonin.
Pterin-dependent tyrosine hydroxylase mRNA is not expressed in human melanocytes or melanoma cells.
Quantitative analysis of tyrosine hydroxylase mRNA for sensitive detection of neuroblastoma cells in blood and bone marrow.
Real-time analysis of tyrosine hydroxylase gene expression: a sensitive and semiquantitative marker for minimal residual disease detection of neuroblastoma.
Real-time RT-PCR of tyrosine hydroxylase to detect bone marrow involvement in advanced neuroblastoma.
Receptor activator of nuclear factor kappaB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly developed model of human neuroblastoma.
Regulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells: elevation induced by analogs of adenosine 3':5'-cyclic monophosphate.
Regulation of tyrosine hydroxylase activity in mouse neuroblastoma clone N1E-115.
Regulation of tyrosine hydroxylase gene expression during differentiation of neuroblastoma cells.
Regulation of tyrosine hydroxylase gene expression in IMR-32 neuroblastoma cells by basic fibroblast growth factor and ciliary neurotrophic factor.
Retroviral transfer of a human tyrosine hydroxylase cDNA in various cell lines: regulated release of dopamine in mouse anterior pituitary AtT-20 cells.
Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of monoamine transporters in neuroblastoma cell lines: correlations to meta-iodobenzylguanidine (MIBG) uptake and tyrosine hydroxylase gene expression.
Reverse transcriptase-polymerase chain reaction as an ancillary molecular technique in the diagnosis of small blue round cell tumors by fine-needle aspiration cytology.
Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson's disease: Reciprocal up-regulation of E6-AP and down-regulation of ?-synuclein.
Sequential detection of tumor cells in the peripheral blood and bone marrow of patients with stage IV neuroblastoma by the reverse transcription-polymerase chain reaction for tyrosine hydroxylase mRNA.
SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a.
Staurosporine potentiates cAMP-mediated promoter activity of the vasoactive intestinal polypeptide gene in rat pheochromocytoma PC12 cells.
Stimulation of tyrosine hydroxylase activity in an adrenergic clone of mouse neuroblastoma by dibutyryl cyclic AMP.
Stimulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells by monocarboxylic acids.
Studies on tyrosine hydroxylase in neuroblastoma in relation to urinary levels of catecholamine metabolites.
Synergy between 5' and 3' flanking regions of the human tyrosine hydroxylase gene ensures specific, high-level expression in neuroblastoma cells.
Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.
TGF-beta1 increases tyrosine hydroxylase expression by a mechanism blocked by BMP-2 in human neuroblastoma SH-SY5Y cells.
The effects of Engelhardtia chrysolepis Hance on long-term memory and potential dopamine involvement in mice.
The MYCN oncoprotein as a drug development target.
The oxysterol 27-hydroxycholesterol regulates ?-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.
Thyroid hormone binding and regulation of adrenergic enzymes in two neuroblastoma cell lines.
Transcriptional enhancement of tyrosine hydroxylase by prostaglandin E2 in SK-N-BE(2) C cells.
Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells.
Translocation of cytosol protein kinase into nuclei and the induction of tyrosine hydroxylase in NBD-2 neuroblastoma cells.
Trichostatin A and Sirtinol Regulate the Expression and Nucleocytoplasmic Shuttling of Histone Deacetylases in All-Trans Retinoic Acid-Induced Differentiation of Neuroblastoma Cells.
TRIM16 inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization.
Tyrosine hydroxylase activity in neuroblastoma and human adrenal gland.
Tyrosine hydroxylase activity in neuroblastoma.
Tyrosine hydroxylase and choline acetyltransferase activity in human neuroblastoma. Correlations with clinical features.
Tyrosine hydroxylase and monoamine oxidase-A activity increases in differentiating human neuroblastoma after elimination of dividing cells.
Tyrosine hydroxylase in neuroblastoma.
Tyrosine hydroxylase-based DNA-vaccination is effective against murine neuroblastoma.
Tyrosine-dependent increase of tyrosine hydroxylase in neuroblastoma cells.
Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies.
Usefulness of tyrosine hydroxylase mRNA for diagnosis and detection of minimal residual disease in neuroblastoma.
Xenogeneic immunization with human tyrosine hydroxylase DNA vaccines suppresses growth of established neuroblastoma.
[Intracerebral transplantation of nerve cells and genetically modified cells for disorders of central nervous system, a basic and clinical study]
[Molecular diagnostic detection of circulating tumor cells and their prognostic implications]
[Supersensitive detection of tyrosine hydroxylase mRNA and neuroblastoma cells by reverse transcription and polymerase chain reaction]
Neurodegenerative Diseases
A link between nanoparticles and Parkinson's disease. Which nanoparticles are most harmful?
A new human pyridinium metabolite of furosemide, inhibitor of mitochondrial complex I, is a candidate inducer of neurodegeneration.
cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3'-untranslated region and poly(C)-binding protein 2.
Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease.
Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases.
Intracellular stability of tyrosine hydroxylase: phosphorylation and proteasomal digestion of the enzyme.
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
Neuroectodermal Tumors
Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies.
Neuroectodermal Tumors, Primitive
Detection of neuroblastoma cells in blood by reverse transcriptase-polymerase chain reaction.
Dynamics of cell proliferation and cell death during the emergence of primitive neuroectodermal tumors of the immature central nervous system in transgenic mice.
Neuroendocrine Tumors
Tyrosine hydroxylase indicates cell differentiation of catecholamine biosynthesis in neuroendocrine tumors.
Neuroinflammatory Diseases
A link between nanoparticles and Parkinson's disease. Which nanoparticles are most harmful?
Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat.
Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats.
Aqueous Extract of Dendropanax morbiferus Leaves Effectively Alleviated Neuroinflammation and Behavioral Impediments in MPTP-Induced Parkinson's Mouse Model.
Circadian rhythm dysfunction: a novel environmental risk factor for Parkinson's disease.
Congenital Cytomegalovirus Infection Alters Olfaction Before Hearing Deterioration In Mice.
Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson's Disease.
Counteracting neuroinflammation in experimental Parkinson's disease favors recovery of function: effects of Er-NPCs administration.
Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson's disease.
Early glycolytic reprogramming controls microglial inflammatory activation.
High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress.
Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice.
Neuroprotective Potential of Adenosine A2A and Cannabinoid CB1 Receptor Antagonists in an Animal Model of Parkinson Disease.
Sodium Butyrate Exacerbates Parkinson's Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model.
The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease.
The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson's disease.
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease.
Neuroma
Neuropeptide- and tyrosine hydroxylase-immunoreactive nerve fibers in painful Morton's neuromas.
Obesity
Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase.
Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity.
Exploring N1-p-Fluorobenzyl-Cymserine as an Inhibitor of 5-Lipoxygenase as a Candidate for Type 2 Diabetes and Neurodegenerative Disorder Treatment.
High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress.
High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice.
[Immediate-early c-fos and tyrosine hydroxylase protein expression in different brain regions in high-fat induced obesity in mice].
Obesity, Abdominal
Dopaminergic Receptors and Tyrosine Hydroxylase Expression in Peripheral Blood Mononuclear Cells: A Distinct Pattern in Central Obesity.
Olivopontocerebellar Atrophies
Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy.
Optic Nerve Injuries
Dark rearing maintains tyrosine hydroxylase expression in retinal amacrine cells following optic nerve transection.
Osteoarthritis
Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target.
Osteosarcoma
Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies.
Ovarian Cysts
In rats with estradiol valerate-induced polycystic ovary syndrome, the acute blockade of ovarian ?-adrenoreceptors improve ovulation.
Pancreatitis, Chronic
Changes in peptidergic innervation in chronic pancreatitis.
Papilloma
Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures.
Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex.
Paraganglioma
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
Developmental gene expression of sympathetic nervous system tumors reflects their histogenesis.
Dopamine-Secreting Paraganglioma in the Retroperitoneum.
Paragangliomas of the craniocervical region. An immunohistochemical study on tyrosine hydroxylase.
Paralysis
A human tyrosine hydroxylase isoform associated with progressive supranuclear palsy shows altered enzymatic activity.
Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease.
Involvement of dopamine receptor in the actions of non-psychoactive phytocannabinoids.
New species of human tyrosine hydroxylase mRNA are produced in variable amounts in adrenal medulla and are overexpressed in progressive supranuclear palsy.
Striatal phosphoproteins in Parkinson disease and progressive supranuclear palsy.
Paraplegia
Dopa-responsive dystonia simulating spastic paraplegia due to tyrosine hydroxylase (TH) gene mutations.
Reserpine induction of tyrosine hydroxylase in paraplegia.
Parkinson Disease
1,25-Dihydroxyvitamin D3 administration to 6-hydroxydopamine-lesioned rats increases glial cell line-derived neurotrophic factor and partially restores tyrosine hydroxylase expression in substantia nigra and striatum.
14-3-3 proteins in neurodegeneration.
?-Methylphenylalanine exerts neuroprotective effects in a Parkinson's disease model by protecting against tyrosine hydroxylase depletion.
A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease.
A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease.
A brief overview of tyrosine hydroxylase and ?-synuclein in the Parkinsonian brain.
A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey.
A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons.
A novel therapeutic approach to 6-OHDA-induced Parkinson's disease in rats via supplementation of PTD-conjugated tyrosine hydroxylase.
A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription.
A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.
A rare novel deletion of the tyrosine hydroxylase gene in Parkinson disease.
A synopsis on the role of tyrosine hydroxylase in Parkinson's disease.
Activation of the HMGB1-RAGE axis upregulates TH expression in dopaminergic neurons via JNK phosphorylation.
Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease.
alpha-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice.
Alpha-synuclein functions as a negative regulator for expression of tyrosine hydroxylase.
alpha-Synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calcium-binding protein- and substance P-positive cells.
Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase.
An experimental study on rat model of parkinsonizm by gene therapy.
Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model.
Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice.
Aquaporin-4 deficiency reduces TGF-?1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease.
Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease.
Bak Foong protects dopaminergic neurons against MPTP-induced neurotoxicity by its anti-apoptotic activity.
BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease.
Behavioral and histopathological consequences of paraquat intoxication in mice: Effects of alpha-synuclein over-expression.
Behavioural Effect of Engineered Cells that Synthesize l-dopa or Dopamine after Grafting into the Rat Neostriatum.
Behavioural effects of genetically engineered cells releasing dopa and dopamine after intracerebral grafting in a rat model of Parkinson's disease.
Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum.
Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease.
CaMKII inhibition ameliorated levodopa-induced dyskinesia by downregulating tyrosine hydroxylase activity in an experimental model of Parkinson's disease.
Cardiac sympathetic denervation and synucleinopathy in Alzheimer's disease with brain Lewy body disease.
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics.
Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.
Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum.
CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.
Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease.
Copper sulfate prevents tyrosine hydroxylase reduced activity and motor deficits in a Parkinson's disease model in mice.
Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector.
Current status of tyrosine hydroxylase in management of Parkinson's disease.
Current trends in the pharmacologic and surgical treatment of Parkinson's disease.
Decrease of medullary catecholaminergic neurons in multiple system atrophy and Parkinson's disease and their preservation in amyotrophic lateral sclerosis.
Decreased tyrosine hydroxylase messenger RNA in the surviving dopamine neurons of the substantia nigra in Parkinson's disease: an in situ hybridization study.
Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson's Disease and Dopa-Responsive Dystonia.
Depletion of nigrostriatal and forebrain tyrosine hydroxylase by S-adenosylmethionine: a model that may explain the occurrence of depression in Parkinson's disease.
Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease.
Development of an enzyme-linked immunosorbent assay (ELISA) to measure tyrosine hydroxylase protein in brain tissue from Parkinson's disease models.
Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons.
Differentiation of Human Dental Pulp Stem Cells into Dopaminergic Neuron-like Cells in Vitro.
Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study.
Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.
Direct Visualization of CHIP-Mediated Degradation of Alpha-Synuclein In Vivo: Implications for PD Therapeutics.
Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: evidence from calorie restriction intervention.
Dopamine release modifies intracellular calcium levels in tyrosine hydroxylase-transfected C6 cells.
Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.
Dopamine turnover and metabolism in the striatum of parkinsonian rats grafted with genetically-modified human astrocytes.
Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease.
Dopaminergic mesencephalic systems and behavioral performance in very old rats.
Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts.
Down regulation of DNA topoisomerase II? exerts neurodegeneration like effect through Rho GTPases in cellular model of Parkinson's disease by Down regulating tyrosine hydroxylase.
Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease.
Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis.
e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease.
Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of Parkinson's disease.
Effect of Bushen Huoxue Decoction on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson's disease.
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
Effect of siRNA-induced silencing of cellular prion protein on tyrosine hydroxylase expression in the substantia nigra of a rat model of Parkinson's disease.
Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease.
Efficacy of Tyrosine Hydroxylase gene modified neural stem cells derived from bone marrow on Parkinson's disease--a rat model study.
Endogenous tetrahydroisoquinolines associated with Parkinson's disease mimic the feedback inhibition of tyrosine hydroxylase by catecholamines.
Essential tremor is not a neurodegenerative disease.
Evaluating Novel RXR Agonists That Induce ApoE and Tyrosine Hydroxylase in Cultured Human Glioblastoma Cells.
Exogeneous expression of L-dopa and dopamine in various cell lines following transfer of rat and human tyrosine hydroxylase cDNA: grafting in an animal model of Parkinson's disease.
Exposure to an enriched environment facilitates motor recovery and prevents short-term memory impairment and reduction of striatal BDNF in a progressive pharmacological model of parkinsonism in mice.
Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli.
Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease.
Gene therapy in a rodent model of Parkinson's disease using differentiated C6 cells expressing a GFAP-tyrosine hydroxylase transgene.
Glatiramer Acetate Reverses Motor Dysfunction and the Decrease in Tyrosine Hydroxylase Levels in a Mouse Model of Parkinson's Disease.
Helper virus-free herpes simplex virus-1 plasmid vectors for gene therapy of Parkinson's disease and other neurological disorders.
HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity.
High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress.
Human albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase in in vitro and in vivo.
Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: ultrastructural evidence for synapse formation using tyrosine hydroxylase immunocytochemistry.
Human neural stem cells genetically modified for brain repair in neurological disorders.
Human tyrosine hydroxylase in Parkinson's disease and in related disorders.
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase.
In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease.
Increased tyrosine hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson's disease.
Indole-Substituted Benzothiazoles and Benzoxazoles as Selective and Reversible MAO-B Inhibitors for Treatment of Parkinson's Disease.
Infection of cultured striatal neurons with a defective HSV-1 vector: implications for gene therapy.
Interaction between ?-synuclein and tau in Parkinson's disease Comment on Wills et al.: Elevated tauopathy and ?-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218.
Interference of alpha-synuclein with cAMP/PKA-dependent CREB signaling for tyrosine hydroxylase gene expression in SK-N-BE(2)C cells.
Intracellular stability of tyrosine hydroxylase: phosphorylation and proteasomal digestion of the enzyme.
Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter.
Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.
Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease.
Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease.
l-Dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic l-amino acid decarboxylase, dopamine and its metabolites in an MPTP mouse model of Parkinson's disease.
Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells.
Levodopa-induced dyskinesias in tyrosine hydroxylase deficiency.
LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson's disease progression.
Long term gene therapy of Parkinson's disease using immortalized rat glial cell line with tyrosine hydroxylase gene.
Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase.
Long-term correction of rat model of Parkinson's disease by gene therapy.
Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease.
Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease.
Loss of non-phosphorylated neurofilament immunoreactivity, with preservation of tyrosine hydroxylase, in surviving substantia nigra neurons in Parkinson's disease.
Low frequency of Parkin, Tyrosine Hydroxylase, and GTP Cyclohydrolase I gene mutations in a Danish population of early-onset Parkinson's Disease.
Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease.
Low-level tyrosine hydroxylase (TH) expression allows for the generation of stable TH+ cell lines of human neural stem cells.
Lower nucleus accumbens ?-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours.
Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity.
Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR.
Mechanism of the neuroprotective effect of injecting brain cells on ST36 in an animal model of Parkinson's disease.
Medullary catecholaminergic neurons in the normal human brain and in Parkinson's disease.
Melanin, tyrosine hydroxylase, calbindin and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuronal susceptibility in Parkinson's disease.
Methyl jasmonate ameliorates rotenone-induced motor deficits in rats through its neuroprotective activity and increased expression of tyrosine hydroxylase immunopositive cells.
Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice.
Modulation of tyrosine hydroxylase expression by melatonin in human SH-SY5Y neuroblastoma cells.
Molecular docking study of catecholamines and [4-(propan-2-yl) phenyl]carbamic acid with tyrosine hydroxylase.
Moving beyond tyrosine hydroxylase to define dopaminergic neurons for use in cell replacement therapies for Parkinson's disease.
Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease.
NeuN is not a reliable marker of dopamine neurons in rat substantia nigra.
Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease.
Neural-targeted gene therapy for rodent and primate hemiparkinsonism.
Neurobehavioral Anomalies in the Pitx3/ak Murine Model of Parkinson's Disease and MPTP.
Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient.
Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy.
Neuroprotective Effect of ?-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways.
Neuroprotective effects of 3-O-demethylswertipunicoside against MPTP-induced Parkinson's disease in vivo and its antioxidant properties in vitro.
Neuroprotective effects of Bak Foong Pill in 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-induced Parkinson's disease model mice.
Neuroprotective effects of the andrographolide analogue AL-1 in the MPP(+)/MPTP-induced Parkinson's disease model in vitro and in mice.
Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy.
Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels.
Nitration in neurodegeneration: deciphering the "Hows" "nYs".
Nitration of soluble proteins in organotypic culture models of Parkinson's disease.
No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferase.
Noggin Along with a Self-Assembling Peptide Nanofiber Containing Long Motif of Laminin Induces Tyrosine Hydroxylase Gene Expression.
Number and nuclear morphology of TH+ and TH- neurons in the mouse ventral midbrain using epifluorescence stereology.
Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells.
Overview of tyrosine hydroxylase in Parkinson's disease.
Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1.
P2X4 receptor participates in autophagy regulation in Parkinson's disease.
P73 and age-related diseases: is there any link with Parkinson Disease?
Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system.
Particle bombardment-mediated gene transfer and expression in rat brain tissues.
Photobiomodulation-induced changes in a monkey model of Parkinson's disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum.
Physical exercise increases the production of tyrosine hydroxylase and CDNF in the spinal cord of a Parkinson's disease mouse model.
Piperine promotes autophagy flux by P2RX4 activation in SNCA/?-synuclein-induced Parkinson disease model.
Preparation of Trojan horse liposomes (THLs) for gene transfer across the blood-brain barrier.
Preservation of midbrain catecholaminergic neurons in very old human subjects.
Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation.
Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures.
Progressive supranuclear palsy: clinico-pathological and biochemical studies.
Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells.
Protective effects of kidney-tonifying Chinese herbal preparation on substantia nigra neurons in a mouse model of Parkinson's disease.
Pyrethroid and organophosphate insecticide exposure in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease: an immunohistochemical analysis of tyrosine hydroxylase and glial fibrillary acidic protein in dorsolateral striatum.
Quantification of mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the substantia nigra in Parkinson's disease and schizophrenia.
Quantification of tyrosine hydroxylase mRNA.
Relationship between neuromelanin and dopamine terminals within the Parkinson's nigrostriatal system.
Restorative Effects of Platelet Derived Growth Factor-BB in Rodent Models of Parkinson's Disease.
Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson's disease: Reciprocal up-regulation of E6-AP and down-regulation of ?-synuclein.
Role of aromatic L-amino acid decarboxylase for dopamine replacement by genetically modified fibroblasts in a rat model of Parkinson's disease.
Selective vulnerability of pigmented dopaminergic neurons in Parkinson's disease.
ser31 tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion.
Serine 129 phosphorylation reduces {alpha}-synuclein's ability to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
Spontaneously Hypertensive Rats (SHR) Are Resistant to a Reserpine-Induced Progressive Model of Parkinson's Disease: Differences in Motor Behavior, Tyrosine Hydroxylase and ?-Synuclein Expression.
Squamosamide derivative FLZ protected tyrosine hydroxylase function in a chronic MPTP/probenecid mouse model of Parkinson's disease.
Stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic MPTP administration in baboons.
Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy.
Striatal GABAergic neuronal activity is not reduced in Parkinson's disease.
Striatal phosphoproteins in Parkinson disease and progressive supranuclear palsy.
Subgroups of parkinsonian patients differentiated by peptidergic immunostaining of caudate nucleus biopsies.
Switching ability of over trained movements in a Parkinson's disease rat model.
The catecholamine system in health and disease -Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes.
The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats.
The delivery of tyrosine hydroxylase accelerates the neurorestoration of Macaca Rhesus model of Parkinson's disease provided by Neurturin.
The expression and significance of tyrosine hydroxylase in the brain tissue of Parkinsons disease rats.
The expression change of glial fibrillary acidic protein and tyrosine hydroxylase in substantia nigra of the Wistar rats exposed to chlorpyrifos: a novel environmental risk factor for Parkinson's disease.
The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea.
The morphology of human neuroblastoma cell grafts in the kainic acid-lesioned basal ganglia of the rat.
The Neuroprotective Mechanism of Low-Frequency rTMS on Nigral Dopaminergic Neurons of Parkinson's Disease Model Mice.
The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway.
The oxysterol 27-hydroxycholesterol regulates ?-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
The role of the regulatory enzymes of catecholamine synthesis in Parkinson's disease.
The therapeutic effects of tyrosine hydroxylase gene transfected hematopoetic stem cells in a rat model of Parkinson's disease.
The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease.
The vulnerability of nigral neurons to Parkinson's disease is unrelated to their intrinsic capacity for dopamine synthesis: an in situ hybridization study.
Therapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease.
Time-Dependent Memory and Gait Improvement by Intranasally-Administered Extracellular Vesicles in Parkinson's Disease Model Rats.
Too much for your own good: Excessive dopamine damages neurons and contributes to Parkinson's disease: An Editorial Highlight for "Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo".
Toxic Equine Parkinsonism: An Immunohistochemical Study of 10 Horses With Nigropallidal Encephalomalacia.
Trace amine metabolism in Parkinson's disease: low circulating levels of octopamine in early disease stages.
Transgenic mice expressing yellow fluorescent protein under control of the human tyrosine hydroxylase promoter.
Transient striatal GLT-1 blockade increases EAAC1 expression, glutamate reuptake, and decreases tyrosine hydroxylase phosphorylation at ser(19).
Transplantation of cells genetically modified and direct intracerebral gene transfer with an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.
Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease.
Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects.
Tyrosine hydroxylase activity in caudate nucleus from Parkinson's disease: effects of iron and phosphorylating agents.
Tyrosine hydroxylase and Parkinson's disease.
Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line--studies in vitro and after intracerebral grafting in vivo.
Tyrosine hydroxylase gene: another piece of the genetic puzzle of Parkinson's disease.
Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency.
Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease.
Tyrosine hydroxylase polymorphism in familial and sporadic Parkinson's disease.
Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease.
Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy.
Tyrosine hydroxylase-immunoreactive neurons are decreased in number in the cerebral cortex of Parkinson's disease.
Tyrosine hydroxylase-like (TH) immunoreactivity in Parkinson's disease and Alzheimer's disease.
Tyrosine hydroxylase: mechanisms of oxygen radical formation.
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.
Up-regulation of tyrosine hydroxylase mRNA in a sub-population of A10 dopamine neurons in Parkinson's disease.
Verbascoside promotes the regeneration of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra.
Viral vectors in the treatment of Parkinson's disease.
Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats.
[Effect of electroacupuncture intervention on levels of SOD, GSH, GSH-Px, MDA, and apoptosis of dopaminergic neurons in substantia Nigra in rats with Parkinson's disease].
[Effect of electroacupuncture on mitochondrial function in mice with Parkinson's disease].
[Effect of electroacupuncture scalp point-through-point therapy on the expression of tyrosine hydroxylase and dopamine transporter mRNAs in substantia nigra of Parkinson's disease model rats]
[Electroacupuncture improved locomotor function by regulating expression of tyrosine hydroxylase and ?-synuclein proteins and transcription activating factor 6 and transcription factor X box binding protein 1 mRNAs in substantia nigra of rats with Parkinson's disease].
[Expression of foreign tyrosine hydroxylase gene in the rat model of Parkinson's disease]
[Fate of human fetal dopamine neurons transplanted into rhesus monkey model of Parkinson's disease: a tyrosine hydroxylase immunocytochemical study]
[Gene therapy of tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and GTP cyclohydrolase genes in rat model of Parkinson's disease]
[Intracerebral transplantation of nerve cells and genetically modified cells for disorders of central nervous system, a basic and clinical study]
[Morphochemical changes in the substantia nigra cellular structures in Parkinson's disease].
[Recombinant adenovirus-mediated expression of tyrosine hydroxylase in 293 cells and activity assay of the expressed protein in vitro by capillary electrophoresis.]
[The changes of striatal dopamine levels in the brain in rat models for Parkinson's disease after gene therapy]
Parkinsonian Disorders
Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease.
Acupuncture for Parkinson's Disease: a review of clinical, animal, and functional Magnetic Resonance Imaging studies.
An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions.
An exploratory evaluation of tyrosine hydroxylase inhibition in planaria as a model for parkinsonism.
Astrocyte-specific expression of tyrosine hydroxylase after intracerebral gene transfer induces behavioral recovery in experimental parkinsonism.
Biphasic effects of MPP+, a possible parkinsonism inducer, on dopamine content and tyrosine hydroxylase mRNA expression in PC12 cells.
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.
Cerebrospinal fluid synaptic proteins as useful biomarkers in tyrosine hydroxylase deficiency.
Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine.
Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with Parkinson's, Alzheimer's with parkinsonism, and Alzheimer's disease.
Extract of Polygala tenuifolia, Angelica tenuissima, and Dimocarpus longan Reduces Behavioral Defect and Enhances Autophagy in Experimental Models of Parkinson's Disease.
Formation and development of Lewy pathology: a critical update.
Four novel mutations in the tyrosine hydroxylase gene in patients with infantile parkinsonism.
Gene disruption of caspase-3 prevents MPTP-induced Parkinson's disease in mice.
GTP cyclohydrolase I gene, tetrahydrobiopterin, and tyrosine hydroxylase gene: their relations to dystonia and parkinsonism.
Hereditary Lewy-body parkinsonism and evidence for a genetic etiology of Parkinson's disease.
Homospecific activity (activity per enzyme protein) of tyrosine hydroxylase increases in parkinsonian brain.
inPentasomes: An innovative nose-to-brain pentamidine delivery blunts MPTP parkinsonism in mice.
Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.
L-dopa-responsive infantile hypokinetic rigid parkinsonism due to tyrosine hydroxylase deficiency.
Levodopa-responsive infantile parkinsonism due to a novel mutation in the tyrosine hydroxylase gene and exacerbation by viral infections.
Linkage analysis of juvenile parkinsonism to tyrosine hydroxylase gene locus on chromosome 11.
Manganese-Mediated Decrease in Levels of c-RET and Tyrosine Hydroxylase Expression In Vitro.
MPTP animal model of Parkinsonism: dopamine cell death or only tyrosine hydroxylase impairment? A study using PET imaging, autoradiography, and immunohistochemistry in the cat.
Neuropathological changes in the caudate nucleus elicited by MPTP and their prevention by monoamine oxidase inhibition.
Neuropathological Findings in Ephedrone Encephalopathy.
Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease.
Neuroprotective changes of thalamic degeneration-related gene expression by acupuncture in an MPTP mouse model of parkinsonism: microarray analysis.
Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter.
Phenylethanolamine N-methyltransferase and other enzymes of catecholamine metabolism in human brain.
Primary astrocytes retrovirally transduced with a tyrosine hydroxylase transgene driven by a glial-specific promoter elicit behavioral recovery in experimental parkinsonism.
Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene.
Reversible Pharmacological Induction of Motor Symptoms in MPTP-Treated Mice at the Presymptomatic Stage of Parkinsonism: Potential Use for Early Diagnosis of Parkinson's Disease.
RNAi of cat-2, a putative tyrosine hydroxylase, increases alpha synuclein aggregation and associated effects in transgenic C. elegans.
Sex differences in the progressive model of parkinsonism induced by reserpine in rats.
Study of a fetal brain affected by a severe form of tyrosine hydroxylase deficiency, a rare cause of early parkinsonism.
Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism.
Tetrahydrobiopterin-dependent functional recovery in 6-hydroxydopamine-treated rats by intracerebral grafting of fibroblasts transfected with tyrosine hydroxylase cDNA.
Tyrosine hydroxylase and dopamine transporter expression in residual dopaminergic neurons: potential contributors to spontaneous recovery from experimental Parkinsonism.
Tyrosine hydroxylase and parkinsonism.
Tyrosine hydroxylase cofactor (tetrahydrobiopterin) in parkinsonism.
Tyrosine hydroxylase deficiency. A unifying concept of Parkinsonism.
Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism.
[A study of divalent metal transporter 1 and ferroportin 1 in brain of rats with manganese-induced parkinsonism].
[Clinical and genetic analysis of a case with infantile Parkinsonism with motor delay due to tyrosine hydroxylase deficiency].
[Neural stem cell, as a source of graft material for transplantation in neuronal disease]
[Tyrosine hydroxylase-immunohistochemical study in the midbrain of experimental MPTP parkinsonism]
Periodontal Diseases
Regulation of tyrosine hydroxylase in periodontal fibroblasts and tissues by obesity-associated stimuli.
Periodontitis
Chronic stress enhances progression of periodontitis via ?1-adrenergic signaling: a potential target for periodontal disease therapy.
Peritonitis
Enhanced Expression of Cardiac Nerve Growth Factor and Nerve Sprouting Markers in Rats following Gastric Perforation: the Association with Cardiac Sympatho-vagal Balance.
Phenylketonurias
"Peripheral" tetrahydrobiopterin deficiency with hyperphenylalaninaemia due to incomplete 6-pyruvoyl tetrahydropterin synthase deficiency or heterozygosity.
Inherited disorders affecting dopamine and serotonin: critical neurotransmitters derived from aromatic amino acids.
Modulation of cerebral catecholamine concentrations during hyperphenylalaninaemia.
Molecular genetics of hereditary dystonia--mutations in the GTP cyclohydrolase I gene.
Pheochromocytoma
"7-tetrahydrobiopterin," a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases.
A comparative immunohistochemical study of spontaneous and chemically induced pheochromocytomas in B6C3F1 mice.
A denaturant-insoluble form of tyrosine hydroxylase in PC12 pheochromocytoma cells.
A nonsecreting pheochromocytoma presenting as an incidental adrenal mass. Report on a case.
A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells.
Activating antibodies to tyrosine hydroxylase.
Activation of rat pheochromocytoma tyrosine hydroxylase by a cyclic AMP-dependent protein kinase in a cell-free system.
Activation of tyrosine 3-monooxygenase in pheochromocytoma cells by adenosine.
Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation.
Allosteric effect of tetrahydrobiopterin cofactors on tyrosine hydroxylase activity.
Alteration of tyrosine hydroxylase activity in PC12 cells infected with herpes simplex virus type 1.
Alternative catecholamine pathways after tyrosine hydroxylase inhibition in malignant pheochromocytoma.
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
Bicyclic monoterpene diols induce differentiation of S91 melanoma and PC12 pheochromocytoma cells by a cyclic guanosine-monophosphate-dependent pathway.
Bradykinin activates tyrosine hydroxylase in rat pheochromocytoma PC-12 cells.
Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase.
Catecholamine metabolism in pheochromocytoma and normal adrenal medullae.
Catecholamine-synthesizing enzymes and chromogranin proteins in drug-induced proliferative lesions of the rat adrenal medulla.
Characterization of Pheochromocytomas in a Mouse Strain with a Targeted Disruptive Mutation of the Neurofibromatosis Gene Nf1.
Characterization of the cytoplasmic proline-directed protein kinase in proliferative cells and tissues as a heterodimer comprised of p34cdc2 and p58cyclin A.
Characterization of the hypoxia-inducible protein binding site within the pyrimidine-rich tract in the 3'-untranslated region of the tyrosine hydroxylase mRNA.
Characterization of the sites phosphorylated on tyrosine hydroxylase by Ca2+ and phospholipid-dependent protein kinase, calmodulin-dependent multiprotein kinase and cyclic AMP-dependent protein kinase.
Cholinergic differentiation of clonal rat pheochromocytoma cells (PC12) induced by retinoic acid: increase of choline acetyltransferase activity and decrease of tyrosine hydroxylase activity.
CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines.
Death by a dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP+) and protection by EGF in GH3 cells.
Deficiency of Phenylethanolamine N-Methyltransferase in Norepinephrine-Producing Pheochromocytoma.
Determination of some molecular parameters of tyrosine hydroxylase from rat adrenal, rat striatum, and human pheochromocytoma.
Developmental gene expression of sympathetic nervous system tumors reflects their histogenesis.
Differential effect of membrane depolarization on levels of tyrosine hydroxylase and dopamine beta-hydroxylase mRNAs in PC12 pheochromocytoma cells.
Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase.
Effect of the 1-methyl-4-phenylpyridinium ion on phosphorylation of tyrosine hydroxylase in rat pheochromocytoma PC12h cells.
Effects of natriuretic peptides (ANP, BNP, CNP) on catecholamine synthesis and TH mRNA levels in PC12 cells.
Effects of PAMP on mRNAs coding for catecholamine-synthesizing enzymes in PC12 cells.
Endogenous von Hippel-Lindau tumor suppressor protein regulates catecholaminergic phenotype in PC12 cells.
Enhanced phosphorylation of tyrosine hydroxylase at more than one site is induced by 56 mM K+ in rat pheochromocytoma PC12 cells in culture.
Epidermal growth factor induces tyrosine hydroxylase in a clonal pheochromocytoma cell line, PC-G2.
ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells.
Evaluation of neurotropic drug actions on tyrosine hydroxylase activity and dopamine metabolism in clonal cell lines.
Expression of mRNA coding for four catecholamine-synthesizing enzymes in human adrenal pheochromocytomas.
Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis.
Expression of tyrosine hydroxylase gene in cultured hypothalamic cells: roles of protein kinase A and C.
Food-derived heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and related amines, as inhibitors of monoamine metabolism.
Glucocorticoid induction of tyrosine hydroxylase in a continous cell line of rat pheochromocytoma.
Glucocorticoids increase catecholamine synthesis and storage in PC12 pheochromocytoma cell cultures.
Growth factor dependence of pheochromocytoma cells in chemically defined medium.
HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors.
Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells.
Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine-rich sequence in the 3'-untranslated region of rat tyrosine hydroxylase mRNA.
Identification of a novel proline-directed serine/threonine protein kinase in rat pheochromocytoma.
Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.
Identification of the secretogranin II-derived peptide EM66 in pheochromocytomas as a potential marker for discriminating benign versus malignant tumors.
IL?1? and TNF?? suppress TGF???promoted NGF expression in periodontal ligament?derived fibroblasts through inactivation of TGF???induced Smad2/3? and p38 MAPK?mediated signals.
Immunocytochemical localization of tyrosine hydroxylase in rat adrenal medulla by the peroxidase labeled antibody method: effects of enzyme activation on ultrastructural distribution of the enzyme.
In vitro translation of mRNA from rat pheochromocytoma tumors, characterization of tyrosine hydroxylase.
Inactivation of tyrosine hydroxylase activity by ascorbate in vitro and in rat PC12 cells.
Increased cell-cell contact stimulates the transcription rate of the tyrosine hydroxylase gene in rat pheochromocytoma PC18 cells.
Increased dopamine production in patients with carcinoid tumors.
Induction of mRNA for tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: evidence for the regulation of tyrosine hydroxylase synthesis by multiple mechanisms in cells exposed to elevated levels of both inducing agents.
Induction of tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: effect of the inducing agents alone or in combination on the enzyme levels and rate of synthesis of tyrosine hydroxylase.
Inhibition of catecholamine synthesis and tyrosine 3-monooxygenase activation in pheochromocytoma cells by diphenylhydantoin.
Inhibition of striatal tyrosine hydroxylase by low concentrations of apomorphine.
Interaction of cyclic AMP and cell-cell contact in the control of tyrosine hydroxylase RNA.
Intracellular localization of tyrosine hydroxylase immunoreactivity in the rat adrenal chromaffin and pheochromocytoma cells.
Isolation, characterization, and application of monoclonal antibodies to rat tyrosine hydroxylase.
Monensin inhibits catecholamine synthesis in pheochromocytoma cells.
Monoclonal antibodies to tyrosine hydroxylase from rat pheochromocytoma PC12h cells with special reference to nerve growth factor-mediated increase of the immunoprecipitable enzymes.
Nerve growth factor-mediated induction of tyrosine hydroxylase in a clonal pheochromocytoma cell line.
Nerve growth factor-mediated stimulation of tyrosine hydroxylase activity in a clonal rat pheochromocytoma cell line.
Overexpression of c-Fos is sufficient to stimulate tyrosine hydroxylase (TH) gene transcription in rat pheochromocytoma PC18 cells.
Overexpression of glia maturation factor (GMF) in PC12 pheochromocytoma cells activates p38 MAP kinase, MAPKAP kinase-2, and tyrosine hydroxylase.
Partial separation and properties of tyrosine hydroxylase from the human pheochromocytoma: effect of norepinephrine.
Permissive action of glucocorticoids in induction of tyrosine hydroxylase by nerve growth factor in a pheochromocytoma cell line.
Pheochromocytomas and ganglioneuromas in the aging rats: morphological and immunohistochemical characterization.
Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes.
Phosphodiesterase 2 negatively regulates adenosine-induced transcription of the tyrosine hydroxylase gene in PC12 rat pheochromocytoma cells.
Phosphorylation and activation of tyrosine hydroxylase in PC18 cells: a cell line derived from rat pheochromocytoma PC12 cells.
Phosphorylation of rat tyrosine hydroxylase and its model peptides in vitro by cyclic AMP-dependent protein kinase.
Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.
Phosphorylation of tyrosine hydroxylase by cyclic GMP-dependent protein kinase.
Phosphorylation of tyrosine hydroxylase on at least three sites in rat pheochromocytoma PC12 cells treated with 56 mM K+: determination of the sites on tyrosine hydroxylase phosphorylated by cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases.
Plasma chromogranin A in pheochromocytoma, primary hyperparathyroidism and pituitary adenoma in comparison with catecholamine, parathyroid hormone and pituitary hormones.
Possible involvements of intracellular Ca2+ and Ca2+ -dependent protein phosphorylation in cholinergic differentiation of clonal rat pheochromocytoma cells (PC12) induced by glioma-conditioned medium and retinoic acid.
Protocatechuic acid inhibits rat pheochromocytoma cell damage induced by a dopaminergic neurotoxin.
Purification and characterization of tyrosine hydroxylase from a clonal pheochromocytoma cell line.
Purification of tyrosine hydroxylase from pheochromocytoma tumors.
Quantitation of tyrosine hydroxylase, protein levels: spot immunolabeling with an affinity-purified antibody.
Rapid activation of tyrosine hydroxylase in response to nerve growth factor.
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
Reduction of enzymatic activity of tyrosine hydroxylase by a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole (Trp-P-1), was due to reduced affinity to a cofactor biopterin.
Reduction of enzyme activity of tyrosine hydroxylase and aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by carcinogenic heterocyclic amines.
Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.
Regulation of human tyrosine hydroxylase activity. Effects of cyclic AMP-dependent protein kinase, calmodulin-dependent protein kinase II and polyanion.
Regulation of the activity of tyrosine hydroxylase in the central nervous system.
Regulation of tyrosine hydroxylase activity in pheochromocytoma PC-12 cells by bradykinin.
Regulation of tyrosine hydroxylase and choline acetyltransferase activities by cell density in the PC12 rat pheochromocytoma clonal cell line.
Regulation of tyrosine hydroxylase from human pheochromocytoma, bovine adrenal and rat striatum.
Regulation of tyrosine hydroxylase gene expression by the m1 muscarinic acetylcholine receptor in rat pheochromocytoma cells.
Regulation of tyrosine hydroxylase gene transcription rate and tyrosine hydroxylase mRNA stability by cyclic AMP and glucocorticoid.
Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase mRNA.
Regulation of tyrosine hydroxylase mRNA levels in rat pheochromocytoma PC12 cells by cell-cell contact.
Regulation of tyrosine hydroxylase phosphorylation in PC12 pheochromocytoma cells by elevated K+ and nerve growth factor. Evidence for different mechanisms of action.
Relationship between activation and phosphorylation of tyrosine hydroxylase by 56 mm K+ in PC12 cells in culture.
Role of the N-terminus of rat pheochromocytoma tyrosine hydroxylase in the regulation of the enzyme's activity.
Simultaneous evaluation of mRNAs of dopamine ?-hydroxylase, tyrosine hydroxylase and proenkephalin a from three human pheochromocytomas.
Simultaneous evaluation of the catecholamine pathway and three opioid peptide-producing systems in human pheochromocytomas.
Studies on dihydropteridine reductase activity in pheochromocytoma cells.
Studies on tyrosine hydroxylase in neuroblastoma in relation to urinary levels of catecholamine metabolites.
Successive occupancy by immediate early transcriptional factors of the tyrosine hydroxylase gene TRE and CRE sites in PACAP-stimulated PC12 pheochromocytoma cells.
Surgical management of pheochromocytoma with the use of metyrosine.
The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells.
The multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca2+-dependent phosphorylation of tyrosine hydroxylase.
The response of the tyrosine hydroxylase gene to cyclic AMP is mediated by two cyclic AMP-response elements.
Thermal stability and CD analysis of rat tyrosine hydroxylase.
Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.
Translation of tyrosine hydroxylase from poly(A)-mRNA in pheochromocytoma cells is enhanced by dexamethasone.
Treatment of PC12 cells by nerve growth factor, dexamethasone, and forskolin. Effects on cell morphology and expression of neurotensin and tyrosine hydroxylase.
Tyrosine 3-monooxygenase from rat pheochromocytoma.
Tyrosine 3-monooxygenase regulates catecholamine synthesis in pheochromocytoma cells.
Tyrosine hydroxylase gene expression in varying forms of human pheochromocytoma.
Tyrosine hydroxylase in human adrenal and pheochromocytoma: localization, kinetics, and catecholamine inhibition.
Tyrosine hydroxylase in human adrenal glands and human pheochromocytoma.
Tyrosine hydroxylase in rat brain dopaminergic nerve terminals. Multiple-site phosphorylation in vivo and in synaptosomes.
Tyrosine hydroxylase is activated and phosphorylated on different sites in rat pheochromocytoma PC12 cells treated with phorbol ester and forskolin.
Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase.
Urocortin stimulates tyrosine hydroxylase activity via the cAMP/protein kinase a pathway in rat Pheochromocytoma PC12 cells.
Vasoactive intestinal peptide increases tyrosine hydroxylase activity in normal and neoplastic rat chromaffin cell cultures.
von Hippel-Lindau protein induces hypoxia-regulated arrest of tyrosine hydroxylase transcript elongation in pheochromocytoma cells.
[A long survived case of malignant pheochromocytoma treated with alpha-methyl-p-tyrosine and midaglizol (DG-5128)]
[Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase]
[Expression of mRNAs coding for catecholamine synthesizing enzymes in human adrenal pheochromocytoma]
[Kinetic property of tyrosine hydroxylase in pheochromocytoma (author's transl)]
[Pathogenesis of Parkinson's disease, a molecular genetic approach]
Pituitary Neoplasms
The stability of endogenous tyrosine hydroxylase protein in PC-12 cells differs from that expressed in mouse fibroblasts by gene transfer.
Placental Insufficiency
BDNF increases survival of retinal dopaminergic neurons after prenatal compromise.
Chronic hypoxemia: effects on developing nitrergic and dopaminergic amacrine cells.
Pneumonia
Activation of tyrosine hydroxylase prevents pneumonia in a rat chronic cerebral hypoperfusion model.
Pneumoperitoneum
The effects of carbon dioxide pneumoperitoneum on tyrosine hydroxylase activity.
Polycystic Ovary Syndrome
In rats with estradiol valerate-induced polycystic ovary syndrome, the acute blockade of ovarian ?-adrenoreceptors improve ovulation.
Polycythemia
Hemoglobins emerging roles in mental disorders. Metabolical, genetical and immunological aspects.
Polyendocrinopathies, Autoimmune
Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems.
Reduction of Total Brain and Cerebellum Volumes Associated With Neuronal Autoantibodies in Patients With APECED.
Pre-Eclampsia
Profound Decrease in Glomerular Arginine Transport by CAT (Cationic Amino Acid Transporter)-1 Contributes to the FLT-1 (FMS-Like Tyrosine Kinase 1) Induced Preeclampsia in the Pregnant Mice.
System y+ arginine transport and NO production in peripheral blood mononuclear cells in pregnancy and preeclampsia.
[Study of follicle-stimulating hormone receptor and tyrosine hydroxylase polymorphisms and pre-eclampsia in Chinese Han population]
Prolactinoma
Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas.
Transfection of human lactotroph adenoma cells with an adenovirus vector expressing tyrosine hydroxylase decreases prolactin release.
[Gene therapy of rat prolactinomas mediated by adenoviral vectors with rat tyrosine hydroxylase gene]
Prurigo
Increased sensory neuropeptides in nodular prurigo: a quantitative immunohistochemical analysis.
Pseudorabies
Distribution of catecholaminergic presympathetic-premotor neurons in the rat lower brainstem.
Dopamine terminals in the rat prefrontal cortex synapse on pyramidal cells that project to the nucleus accumbens.
Dopamine terminals synapse on callosal projection neurons in the rat prefrontal cortex.
Pulmonary Edema
Elevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGF?1, and TNF? associated with high-altitude pulmonary edema in an Indian population.
Polymorphisms of the tyrosine hydroxylase gene in subjects susceptible to high-altitude pulmonary edema.
Refractive Errors
Altered Refractive Development in Mice With Reduced Levels of Retinal Dopamine.
Reperfusion Injury
Activation of Different Neuronal Phenotypes in the Rat Brain Induced by Liver Ischemia-Reperfusion Injury: Dual Fos/Neuropeptide Immunohistochemistry.
Respiratory Insufficiency
Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1.
Restless Legs Syndrome
Association between Antipsychotics-Induced Restless Legs Syndrome and Tyrosine Hydroxylase Gene Polymorphism.
Retroviridae Infections
Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes.
Rett Syndrome
Discussant--pathophysiologies of Rett syndrome.
Substance P immunoreactivity in the enteric nervous system in Rett syndrome.
Rhabdomyosarcoma
HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors.
Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies.
Rhabdomyosarcoma, Embryonal
A new highly polymorphic DNA restriction site marker in the 5' region of the human tyrosine hydroxylase gene (TH) detecting loss of heterozygosity in human embryonal rhabdomyosarcoma.
Hemihypertrophy and a poorly differentiated embryonal rhabdomyosarcoma of the pelvis.
Rickets
RNAi-Mediated Functional Analysis of Bursicon Genes Related to Adult Cuticle Formation and Tanning in the Honeybee, Apis mellifera.
ring-type e3 ubiquitin transferase deficiency
Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease.
Rubinstein-Taybi Syndrome
Hemoglobins emerging roles in mental disorders. Metabolical, genetical and immunological aspects.
Sarcoma
Hemihypertrophy and a poorly differentiated embryonal rhabdomyosarcoma of the pelvis.
Scrapie
Alterations in neurotransmitter-related enzyme activity in scrapie-infected PC12 cells.
Changes in tyrosine hydroxylase, glutamic acid decarboxylase and choline acetyltransferase after local microinoculation of scrapie agent into the nigrostriatal system of the golden hamster.
Close interactions between sympathetic neural fibres and follicular dendritic cells network are not altered in Peyer's patches and spleen of C57BL/6 mice during the preclinical stage of 139A scrapie infection.
Early changes in tyrosine hydroxylase and glutamate decarboxylase activity in the golden hamster striatum after intracerebral inoculation of the nigrostriatal system with scrapie agent (strain 263 K).
Scurvy
Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig.
Seizures
Altered patterns of catecholaminergic fibers in focal cortical dysplasia in two patients with partial seizures.
Catecholamines and pinealectomy-induced convulsions in the gerbil (Meriones unguiculatus).
Comparison of neurons in rat medulla oblongata with fos immunoreactivity evoked by seizures, chemoreceptor, or baroreceptor stimulation.
Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice.
Effect of repeated seizure experiences on tyrosine hydroxylase immunoreactivities in the brain of genetically epilepsy-prone rats.
Electroconvulsive shock increases tyrosine hydroxylase and neuropeptide Y gene expression in the locus coeruleus.
Increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission.
Levels of biogenic amines, their metabolites, and tyrosine hydroxylase activity in the human epileptic temporal cortex.
Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke.
Reduced immunoreactivity of tyrosine hydroxylase in the hypothalamic paraventricular nucleus of the seizure sensitive gerbil.
Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures.
Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a.
Tyrosine hydroxylase-immunoreactive neurons in the temporal lobe in complex partial seizures.
Sepsis
Increased gut-derived norepinephrine release in sepsis: up-regulation of intestinal tyrosine hydroxylase.
Loss of Sympathetic Nerves in Spleens from Patients with End Stage Sepsis.
Platonin attenuates LPS-induced CAT-2 and CAT-2B induction in stimulated murine macrophages.
Siderosis
Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment.
Sleep Apnea Syndromes
KNOCKDOWN OF TYROSINE HYDROXYLASE IN THE NUCLEUS OF THE SOLITARY TRACT REDUCES ELEVATED BLOOD PRESSURE DURING CHRONIC INTERMITTENT HYPOXIA.
Sleep Deprivation
Increased levels of tyrosine hydroxylase and glutamic acid decarboxylase in locus coeruleus neurons after rapid eye movement sleep deprivation in rats.
Kinetic parameters of tyrosine hydroxylase in the rat's preoptic region during sleep deprivation and recovery induced by ambient temperature.
Noradrenergic activity in rat brain during rapid eye movement sleep deprivation and rebound sleep.
Paradoxical sleep deprivation modulates tyrosine hydroxylase expression in the nigrostriatal pathway and attenuates motor deficits induced by dopaminergic depletion.
REM sleep deprivation increases the levels of tyrosine hydroxylase and norepinephrine transporter mRNA in the locus coeruleus.
Sleep deprivation affects sexual behavior and tyrosine hydroxylase (TH) levels in sexually experienced male rats.
The dopaminergic system of the telencephalo-diencephalic areas of the vertebrate brain in the organization of the sleep-waking cycle.
Tyrosine hydroxylase activity in rat brain following "REM" sleep deprivation.
[Diencephalo-telencephalic changes of tyrosine hydroxylase in rats and common frogs (Rana temporaria) after sleep deprivation]
[Morphfunctional interaction of cart-peptide and dopaminergic brain neurons].
Spinal Cord Injuries
Alterations in norepinephrine, serotonin, c-AMP, and transsynaptic induction of tyrosine hydroxylase after spinal cord transection in the rat.
Differential effects of transection of the spinal cord and splanchnic nerve on adrenal tyrosine hydroxylase and catecholamines.
Spinocerebellar Ataxias
Psychosis in Spinocerebellar Ataxias: a Case Series and Study of Tyrosine Hydroxylase in Substantia Nigra.
Starvation
Effect of starvation on hypothalamic tyrosine hydroxylase activity in adult male rats.
The role of dopamine in learning, memory, and performance of a water escape task.
Status Epilepticus
Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures.
Stomach Neoplasms
Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population.
Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis.
Loss of Sympathetic Nerve Fibers Around Intratumoral Arterioles Reflects Malignant Potential of Gastric Cancer.
Lower Sympathetic Nervous System Density and ?-adrenoreceptor Expression Are Involved in Gastric Cancer Progression.
Stomach Ulcer
Anti-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injury.
Gastric ulcer formation in cold-stressed mice related to a central calcium-dependent-dopamine synthesizing system.
Stomatitis
[Effect of anaprilin on the tyrosine hydroxylase activity of the oral mucosa in dogs with experimental stomatitis]
Stomatitis, Aphthous
[Effect of anaprilin on the tyrosine hydroxylase activity of the oral mucosa in dogs with experimental stomatitis]
Stroke
Colchicine affects cortical and amygdalar neurochemical changes differentially after middle cerebral artery occlusion in rats.
Exploring N1-p-Fluorobenzyl-Cymserine as an Inhibitor of 5-Lipoxygenase as a Candidate for Type 2 Diabetes and Neurodegenerative Disorder Treatment.
Neurovascular Specifications in the Alzheimer-Like Brain of Mice Affected by Focal Cerebral Ischemia: Implications for Future Therapies.
Reversible changes in the activities of tyrosine hydroxylase and dopamine-beta-hydroxylase in neurons of the nucleus locus coeruleus after experimental stroke.
Stupor
Behavioral and neurochemical effects induced by subchronic exposure to 40 ppm toluene in rats.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Outcome of Patients With Inherited Neurotransmitter Disorders.
Sudden Unexpected Death in Epilepsy
Medullary tyrosine hydroxylase catecholaminergic neuronal populations in sudden unexpected death in epilepsy.
Supranuclear Palsy, Progressive
A human tyrosine hydroxylase isoform associated with progressive supranuclear palsy shows altered enzymatic activity.
Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease.
New species of human tyrosine hydroxylase mRNA are produced in variable amounts in adrenal medulla and are overexpressed in progressive supranuclear palsy.
Striatal phosphoproteins in Parkinson disease and progressive supranuclear palsy.
Synucleinopathies
alpha-Synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calcium-binding protein- and substance P-positive cells.
Tardive Dyskinesia
No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia.
Tendinopathy
Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon.
Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man.
Sympathetic Innervation and Adrenergic Receptors in Equine Deep Digital Flexor Tendinopathy: Preliminary Results.
Teratocarcinoma
Lithium chloride induces the expression of tyrosine hydroxylase in hNT neurons.
Teratoma
Analyses of novel prognostic factors in neuroblastoma patients.
Thyroid Neoplasms
MEN2 Syndrome-Related Medullary Thyroid Carcinoma with Focal Tyrosine Hydroxylase Expression: Does It Represent a Hybrid Cellular Phenotype or Functional State of Tumor Cells?
Tic Disorders
Hemoglobins emerging roles in mental disorders. Metabolical, genetical and immunological aspects.
Tics
Effects of catecholamine depletion with AMPT (alpha-methyl-para-tyrosine) in obsessive-compulsive disorder.
Tourette Syndrome
No association of a tyrosine hydroxylase gene tetranucleotide repeat polymorphism in autism, Tourette syndrome, or ADHD.
The genetic susceptibility to Gilles de la Tourette syndrome in a large multiple affected British kindred: linkage analysis excludes a role for the genes coding for dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase, and tyrosine hydroxylase.
Toxoplasmosis
Identification of Toxoplasma Gondii Tyrosine Hydroxylase (TH) Activity and Molecular Immunoprotection against Toxoplasmosis.
Serum Tyrosine Level in Acute Murine Toxoplasmosis.
Tremor
Compound heterozygous mutations in the TH gene in a Chinese family with autosomal-recessive dopa-responsive dystonia: A case report.
Study on antrodia camphorata polysaccharide in alleviating the neuroethology of PD mice by decreasing the expression of NLRP3 inflammasome.
tryptophan 5-monooxygenase deficiency
Role of brain cytochrome P450 (CYP2D) in the metabolism of monoaminergic neurotransmitters.
Turner Syndrome
Absence of autoantibodies connected to autoimmune polyendocrine syndrome type I and II and Addison's disease in girls and women with Turner syndrome.
tyrosine 3-monooxygenase deficiency
A New Tyrosine Hydroxylase Genotype Associated With Early-Onset Severe Encephalopathy.
A novel missense mutation pattern of the GCH1 gene in dopa-responsive dystonia.
A review of biochemical and molecular genetic aspects of tyrosine hydroxylase deficiency including a novel mutation (291delC).
An Indian Family with Tyrosine Hydroxylase Deficiency.
An unusual presentation of tyrosine hydroxylase deficiency.
Bilateral subthalamic nucleus deep brain stimulation for dopa-responsive dystonia in a 6-year-old child.
Biochemical and molecular characterization of tyrosine hydroxylase deficiency in Hong Kong Chinese.
Biochemical and molecular genetic characteristics of the severe form of tyrosine hydroxylase deficiency.
Biochemical hallmarks of tyrosine hydroxylase deficiency.
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.
Brain MR patterns in inherited disorders of monoamine neurotransmitters: An analysis of 70 patients.
Cerebrospinal fluid synaptic proteins as useful biomarkers in tyrosine hydroxylase deficiency.
Compound heterozygous mutations in the TH gene in a Chinese family with autosomal-recessive dopa-responsive dystonia: A case report.
Diagnosing dopamine-responsive dystonias.
Diagnosis and Treatment of Neurotransmitter Disorders.
Dopa-responsive dystonia caused by tyrosine hydroxylase deficiency: Three cases report and literature review.
Dopa-responsive dystonia due to mild tyrosine hydroxylase deficiency.
Effects of a rat model of gestational hypothyroidism on forebrain dopaminergic, GABAergic, and serotonergic systems and related behaviors.
Expanding Phenotype and Clinical Analysis of Tyrosine Hydroxylase Deficiency.
Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in Dopa-responsive dystonia.
L-dopa and selegiline for tyrosine hydroxylase deficiency.
L-dopa-responsive infantile hypokinetic rigid parkinsonism due to tyrosine hydroxylase deficiency.
Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase.
Levodopa-induced dyskinesias in tyrosine hydroxylase deficiency.
Long-term course of L-dopa-responsive dystonia caused by tyrosine hydroxylase deficiency.
Myoclonus-dystonia syndrome due to tyrosine hydroxylase deficiency.
Neuromotor and cognitive outcomes of early treatment in tyrosine hydroxylase deficiency type B.
Novel mutations in the tyrosine hydroxylase gene in the first Czech patient with tyrosine hydroxylase deficiency.
Novel Protein Biomarkers of Monoamine Metabolism Defects Correlate with Disease Severity.
Pediatric neurotransmitter diseases.
Pre- and postnatal diagnosis of tyrosine hydroxylase deficiency.
Study of a fetal brain affected by a severe form of tyrosine hydroxylase deficiency, a rare cause of early parkinsonism.
Teaching Video NeuroImage: Improvement in Motor Development After Start of Levodopa in Tyrosine Hydroxylase Deficiency.
The pediatric neurotransmitter disorders.
Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia.
Tyrosine hydroxylase deficiency in Taiwanese infants.
Tyrosine hydroxylase deficiency in three Greek patients with a common ancestral mutation.
Tyrosine hydroxylase deficiency presenting with a biphasic clinical course.
Tyrosine hydroxylase deficiency unresponsive to L-dopa treatment with unusual clinical and biochemical presentation.
Tyrosine hydroxylase deficiency with severe clinical course.
Tyrosine hydroxylase deficiency with severe clinical course: clinical and biochemical investigations and optimization of therapy.
Tyrosine hydroxylase deficiency-Clinical insights and a novel deletion in TH gene in an Indian patient.
Tyrosine hydroxylase deficiency. A unifying concept of Parkinsonism.
Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis.
Tyrosine hydroxylase deficiency: clinical manifestations of catecholamine insufficiency in infancy.
[Tyrosine hydroxylase deficiency: a case of autosomal recessive dopa-responsive dystonia].
Uremia
Activities of cerebral dihydropteridine reductase and tyrosine hydroxylase in chronic uremia in rats.
Urinary Incontinence
Systemic and topical hormone therapies reduce vaginal innervation density in postmenopausal women.
Ventricular Fibrillation
Pinocembrin Decreases Ventricular Fibrillation Susceptibility in a Rat Model of Depression.
Virus Diseases
Levodopa-responsive infantile parkinsonism due to a novel mutation in the tyrosine hydroxylase gene and exacerbation by viral infections.
Tyrosine hydroxylase activity in the superior cervical ganglion during herpes simplex virus infection: correlation with viral titers and viral antigen.
Tyrosine hydroxylase activity in Venezuelan equine encephalomyelitis virus infection.
Vitamin E Deficiency
Nigral dopaminergic cell loss in vitamin E deficient rats.
Vitiligo
Autoantibodies against tyrosine hydroxylase in patients with non-segmental (generalised) vitiligo.
Epitopes, Avidity and IgG Subclasses of Tyrosine Hydroxylase Autoantibodies in Patients with Vitiligo and Alopecia Areata.
Melanocyte antigen-specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo.
Whooping Cough
Effects of pertussis toxin on inhibition of synaptosomal tyrosine hydroxylase activity by apomorphine.
Inhibition of dopamine synthesis by dopamine D2 and D3 but not D4 receptors.
Wilms Tumor
Detection of neuroblastoma cells in blood by reverse transcriptase-polymerase chain reaction.
Expression of Wilms tumor gene in high risk neuroblastoma: complementary marker to tyrosine hydroxylase for detection of minimal residual disease.
Wolfram Syndrome
Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.