Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.2 extracted from

  • Hallen, A.; Cooper, A.J.
    Reciprocal control of thyroid binding and the pipecolate pathway in the brain (2017), Neurochem. Res., 42, 217-243 .
    View publication on PubMed
Search for more literature for 1.5.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-pyrroline-5-carboxylate + NADH + H+ Homo sapiens
-
 L-proline + NAD+
-
 ?
1-pyrroline-5-carboxylate + NADPH + H+ Homo sapiens
-
 L-proline + NADP+
-
 ?
L-pipecolate + NAD+ Homo sapiens
-
 DELTA1-piperideine 6-carboxylate + NADH + H+
-
 ?
L-pipecolate + NADP+ Homo sapiens
-
 DELTA1-piperideine 6-carboxylate + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96C36
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-pyrroline-5-carboxylate + NADH + H+
-
 Homo sapiens L-proline + NAD+
-
 ?
1-pyrroline-5-carboxylate + NADPH + H+
-
 Homo sapiens L-proline + NADP+
-
 ?
L-pipecolate + NAD+
-
 Homo sapiens DELTA1-piperideine 6-carboxylate + NADH + H+
-
 ?
L-pipecolate + NADP+
-
 Homo sapiens DELTA1-piperideine 6-carboxylate + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
aldimine reductase
-
 Homo sapiens
DELTA1-pyrroline-5-carboxylate reductase
-
 Homo sapiens
Pyr5C reductase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 7 about 60% higher reaction rate at pH 5.0 compared to pH 7.0 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADH
-
 Homo sapiens
NADP+
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
evolution enzymes that reduce DELTA1-pyrroline-5-carboxylate and DELTA1-piperideine-6-carboxylate are aldimine reductases whereas enzymes that reduce DELTA1-piperideine-2-carboxylate and DELTA1-pyrroline-2-carboxylate (P2C/Pyr2C) are ketimine reductases (KRs) Homo sapiens
metabolism mammalian tissues contain a Pyr5C/P6C reductase that is distinct from Pyr2C/P2C reductase. In higher eukaryotes Pyr5C is also generated by a mitochondrial isozyme Pyr5C synthetase (isozyme PYCR1, UniProt ID P32322). Lysine/ornithine catabolism and interconnected pathways with 5-carbon amino acid (L-glutamate gamma-semialdehyde, L-glutamate, L-ornithine, L-proline) metabolism in mammalian tissues, overview. Although the ketimine reductase (KR) is important in the formation of L-pipecolate in the brain, it is also an important source of L-proline. This proline (via proline oxidase) in turn is an important source of Pyr5C and hence of glutamate and to a lesser extent ornithine Homo sapiens
physiological function L-proline has important roles in mammalian bioenergetics, cellular redox control, apoptosis and cancer. In mammals, Pyr5C reductase exists in two isoforms: a short form is present in the intestine that is feedback inhibited by ornithine and may be important in the synthesis of L-arginine from L-glutamate in the intestine. On the other hand, most other tissues express a long form of DELTA1-pyrroline-5-carboxylate reductase, which is thought to be important in the synthesis of L-proline from L-glutamate Homo sapiens