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Literature summary for 1.14.17.3 extracted from
- Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system (2005), FEBS J., 272, 942-955.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence determination and analysis, phylogenetic analysis | Dugesia japonica |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | localization around the nuclei | Dugesia japonica | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | essentially required for activity, 2 atoms bound by 5 conserved His residues and 1 conserved Met residue | Dugesia japonica |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Dugesia japonica | enzyme is required for amidation of the C-terminus of neuropeptides | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dugesia japonica | Q4W7B5 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | neuronal cell bodies, axon bundles | Dugesia japonica | - |
| eye | expression only in the photoreceptor cells adjacent to the eye cup | Dugesia japonica | - |
| additional information | tissue expression pattern, the enzyme colocalizes with cytochrome b561 along the central nervous system | Dugesia japonica | - |
| neuron | - |
Dugesia japonica | - |
| ventral nerve cord | - |
Dugesia japonica | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme is required for amidation of the C-terminus of neuropeptides | Dugesia japonica | ? | - |
? | |
| peptidylglycine + ascorbate + O2 | peptidylglycine alpha-hydroxylating monooxygenase PHM reaction | Dugesia japonica | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| peptidylglycine alpha-hydroxylating monooxygenase | - |
Dugesia japonica |
| PHM | - |
Dugesia japonica |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ascorbate | - |
Dugesia japonica | |
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Release 2023.1 (January 2023)
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