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Literature summary for 1.13.11.52 extracted from

  • Roy, E.J.; Takikawa, O.; Kranz, D.M.; Brown, A.R.; Thomas, D.L.
    Neuronal localization of indoleamine 2,3-dioxygenase in mice (2005), Neurosci. Lett., 387, 95-99.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
gamma-interferon induces IDO expression Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-tryptophan + O2 Mus musculus
-
N-formyl-D-kynurenine
-
?
L-tryptophan + O2 Mus musculus
-
N-formyl-L-kynurenine
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus
-
C57BL6J and murine cell lines P815B murine mastocytoma cells
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
hippocampus neurons, level of activity is lower than in monocytic cells in lymph nodes Mus musculus
-
hippocampus the enzyme is upregulated by interferon-gamma in neurons of the hippocampus Mus musculus
-
macrophage
-
Mus musculus
-
microglia
-
Mus musculus
-
additional information entorhinal cortex Mus musculus
-
neuron the enzyme is upregulated by interferon-gamma in neurons of the hippocampus. The enzyme could contribute to the vulnerability of neurons to inflammatory conditions Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-tryptophan + O2
-
Mus musculus N-formyl-D-kynurenine
-
?
L-tryptophan + O2
-
Mus musculus N-formyl-L-kynurenine
-
?

Synonyms

Synonyms Comment Organism
IDO
-
Mus musculus