Activating Compound | Comment | Organism | Structure |
---|---|---|---|
gamma-interferon | induces IDO expression | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | Mus musculus | - |
N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | Mus musculus | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | - |
C57BL6J and murine cell lines P815B murine mastocytoma cells | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
hippocampus | neurons, level of activity is lower than in monocytic cells in lymph nodes | Mus musculus | - |
hippocampus | the enzyme is upregulated by interferon-gamma in neurons of the hippocampus | Mus musculus | - |
macrophage | - |
Mus musculus | - |
microglia | - |
Mus musculus | - |
additional information | entorhinal cortex | Mus musculus | - |
neuron | the enzyme is upregulated by interferon-gamma in neurons of the hippocampus. The enzyme could contribute to the vulnerability of neurons to inflammatory conditions | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | - |
Mus musculus | N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Mus musculus | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Mus musculus |