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Literature summary for 1.14.13.9 extracted from

  • Gonzalez Esquivel, D.; Ramirez-Ortega, D.; Pineda, B.; Castro, N.; Rios, C.; Perez de la Cruz, V.
    Kynurenine pathway metabolites and enzymes involved in redox reactions (2017), Neuropharmacology, 112, 331-345 .
    View publication on PubMed
Search for more literature for 1.14.13.9

Organism

Organism UniProt Comment Textmining
Homo sapiens O15229
-
-
Rattus norvegicus O88867
-
-

Source Tissue

Source Tissue Comment Organism Textmining
microglia
-
 Homo sapiens
-
microglia
-
 Rattus norvegicus
-
neuron
-
 Homo sapiens
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + NADPH + H+ + O2
-
 Homo sapiens 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
L-kynurenine + NADPH + H+ + O2
-
 Rattus norvegicus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein Homo sapiens
FAD flavoprotein Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus expression level is upregulated by pro-inflammatory cytokines up

General Information

General Information Comment Organism
metabolism the enzyme is involved in kynurenine pathway. It catalyzes the decisive step in production of metabolites as quinolinic acid Homo sapiens
metabolism the enzyme is very important in kynurenine pathway because it catalyzes the decisive step in production of metabolites as quinolinic acid Rattus norvegicus