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Literature summary for 1.14.16.4 extracted from

  • Bach-Mizrachi, H.; Underwood, M.D.; Tin, A.; Ellis, S.P.; Mann, J.J.; Arango, V.
    Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides (2008), Mol. Psychiatry, 13, 507-13, 465.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens the enzyme is rate-limiting in serotonin biosynthesis, deficient levels of serotonin are associated with suicide and depression 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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 ?
additional information Homo sapiens localized changes in TPH2 expression in specific subnuclei of the dorsal raphe nucleus suggest that the serotonergic compensatory mechanism in depression and suicide is specifically regulated within the DRN and has implications for regions innervated by this subnucleus, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IWU9
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain dorsal and median raphe nuclei, in the dorsal raphe nucleus there are more serotonin neurons and more neuronal TPH2 expression postmortem in depressed suicides. Depressed suicides have 26.5% more TPH2 grain density per neuron in the DRN compared with matched controls Homo sapiens
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brain stem expression analysis Homo sapiens
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neuron TPH2, serotonergic neurons Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 the enzyme is rate-limiting in serotonin biosynthesis, deficient levels of serotonin are associated with suicide and depression Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information localized changes in TPH2 expression in specific subnuclei of the dorsal raphe nucleus suggest that the serotonergic compensatory mechanism in depression and suicide is specifically regulated within the DRN and has implications for regions innervated by this subnucleus, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TPH
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 Homo sapiens
TPH2
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 Homo sapiens
tryptophan hydroxylase
-
 Homo sapiens
tryptophan hydroxylase-2
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 Homo sapiens