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Information on EC 1.14.11.53 - mRNA N6-methyladenine demethylase

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IUBMB Comments
Contains iron(II). Catalyses oxidative demethylation of mRNA N6-methyladenine. The FTO enzyme from human can also demethylate N3-methylthymine from single stranded DNA and N3-methyluridine from single stranded RNA [1,2] with low activity .
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Word Map
  • 1.14.11.53
  • demethylation
  • demethylases
  • mettl14
  • reader
  • writer
  • erasers
  • epitranscriptomic
  • ythdf1
  • m6a-related
  • hnrnpc
  • m6a-binding
  • igf2bp1
  • merip
  • m6a-dependent
  • methyltransferase-like
  • m6a-modified
The enzyme appears in viruses and cellular organisms
Reaction Schemes
N6-methyladenine in mRNA
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adenine in mRNA
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Synonyms
AlkB homolog 5, ALKBH5, ALKBH5 demethylase, fat mass and obesity-associated protein, FTO, m6A mRNA demethylase, m6A RNA demethylase, m6A-RNA demethylase, N6-methyladenosine demethylase, RNA N6-methyladenine demethylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N6-methyladenine in mRNA + 2-oxoglutarate + O2 = adenine in mRNA + formaldehyde + succinate + CO2
show the reaction diagram
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