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Literature summary for 1.14.11.53 extracted from

  • Zheng, G.
    Dahl, J.A.; Niu, Y.; Fedorcsak, P.; Huang, C.M.; Li, C.J.; Vagbo, C.B.; Shi, Y.; Wang, W.L.; Song, S.H.; Lu, Z.; Bosmans, R.P.; Dai, Q.; Hao, Y.J.; Yang, X.; Zhao, W.M.; Tong, W.M.; Wang, X.J.; Bogdan, F.; Furu, K.; Fu, Y.; Jia, G.; Zhao, X.; Liu, J.; Krokan, H.E.; Klungland, A.; Yang, Y.G.; He, C.: ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility (2013), Mol. Cell, 49, 18-29.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in the BL21 (DE3) Escherichia coli strain Homo sapiens

Protein Variants

Protein Variants Comment Organism
H204A inactive mutant enzyme Homo sapiens
H266A activity is significantly compromised Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus localised in nuclear speckles, which are subnuclear structures that are enriched in pre-messenger RNA splicing factors Homo sapiens 5634
-
nucleus localised in nuclear speckles, which are subnuclear structures that are enriched in pre-messenger RNA splicing factors Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6-methyladenine in mRNA + 2-oxoglutarate + O2 Homo sapiens
-
adenine in mRNA + formaldehyde + succinate + CO2
-
?
N6-methyladenine in mRNA + 2-oxoglutarate + O2 Mus musculus
-
adenine in mRNA + formaldehyde + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6P6C2
-
-
Mus musculus Q3TSG4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-methyladenine in mRNA + 2-oxoglutarate + O2
-
Homo sapiens adenine in mRNA + formaldehyde + succinate + CO2
-
?
N6-methyladenine in mRNA + 2-oxoglutarate + O2
-
Mus musculus adenine in mRNA + formaldehyde + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
ALKBH5
-
Homo sapiens
ALKBH5
-
Mus musculus

General Information

General Information Comment Organism
malfunction Alkbh5-deficient male mice have increased m6A in mRNA and are characterized by impaired fertility resulting from apoptosis that affects meiotic metaphase stage spermatocytes Homo sapiens
malfunction Alkbh5-deficient male mice have increased m6A in mRNA and are characterized by impaired fertility resulting from apoptosis that affects meiotic metaphase stage spermatocytes Mus musculus