Cloned (Comment) | Organism |
---|---|
expression in the BL21 (DE3) Escherichia coli strain | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H204A | inactive mutant enzyme | Homo sapiens |
H266A | activity is significantly compromised | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | localised in nuclear speckles, which are subnuclear structures that are enriched in pre-messenger RNA splicing factors | Homo sapiens | 5634 | - |
nucleus | localised in nuclear speckles, which are subnuclear structures that are enriched in pre-messenger RNA splicing factors | Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N6-methyladenine in mRNA + 2-oxoglutarate + O2 | Homo sapiens | - |
adenine in mRNA + formaldehyde + succinate + CO2 | - |
? | |
N6-methyladenine in mRNA + 2-oxoglutarate + O2 | Mus musculus | - |
adenine in mRNA + formaldehyde + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6P6C2 | - |
- |
Mus musculus | Q3TSG4 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N6-methyladenine in mRNA + 2-oxoglutarate + O2 | - |
Homo sapiens | adenine in mRNA + formaldehyde + succinate + CO2 | - |
? | |
N6-methyladenine in mRNA + 2-oxoglutarate + O2 | - |
Mus musculus | adenine in mRNA + formaldehyde + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALKBH5 | - |
Homo sapiens |
ALKBH5 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Alkbh5-deficient male mice have increased m6A in mRNA and are characterized by impaired fertility resulting from apoptosis that affects meiotic metaphase stage spermatocytes | Homo sapiens |
malfunction | Alkbh5-deficient male mice have increased m6A in mRNA and are characterized by impaired fertility resulting from apoptosis that affects meiotic metaphase stage spermatocytes | Mus musculus |