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Information on EC 1.1.1.188 - prostaglandin-F synthase

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IUBMB Comments
Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
pgfs, akr1b7, prostaglandin f synthase, pgf synthase, vas deferens protein, prostaglandin f synthetase, prostamide/pgf synthase, p100/11e, pgf2alpha synthase, prostaglandin f2alpha synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
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PATHWAY SOURCE
PATHWAYS