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EC 1.13.1.12
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formerly
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indolamine 2,3-dioxygenase
indole 2,3-dioxygenase
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indoleamine 2, 3-dioxygenase
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indoleamine 2,3 dioxygenase
indoleamine 2,3-dioxygenase
indoleamine 2,3-dioxygenase 1
indoleamine 2,3-dioxygenase 2
indoleamine 2,3-dioxygenase-1
indoleamine 2,3-dioxygenase-2
indoleamine 2,3-dioxygenase-like protein
indoleamine-2,3-dioxygenase
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Indoleamine-pyrrole 2,3-dioxygenase
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L-tryptophan 2,3-dioxygenase
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L-tryptophan pyrrolase
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oxygenase, tryptophan 2,3-di-
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proto-indoleamine 2,3-dioxygenase
Tryptamin 2,3-dioxygenase
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tryptamine 2,3-dioxygenase
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tryptophan 2,3-dioxygenase
tryptophan peroxidase
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tryptophan pyrrolase
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tryptophan-2,3-dioxygenase
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hIDO
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IDO
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IDO
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395463, 395469, 657493, 657494, 657496, 659233, 659651, 660112, 660438, 660498, 664443, 666239, 666378, 666763, 666895, 671714, 674188, 675506, 676846, 688728, 710824, 711218, 711247, 711422, 711580, 711776, 712112, 712172, 712173, 712250, 712647, 712820, 712832, 712945, 712947, 724912, 725120, 725522, 726383
IDO
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395502, 395503, 395504, 688457, 711229, 711910, 712694, 712906, 713484, 742073, 742634, 742699, 743005, 743064, 743296, 764273, 764301
IDO-1
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IDO-2
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IDO1
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IDO1
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724429, 741581, 742442, 743005, 743064, 743654, 764286, 764291, 764292, 764294, 764295, 764396, 764463, 765149, 765221, 765223, 765226, 765311, 765422, 765516
IDO2
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INDO
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INDOL1
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indolamine 2,3-dioxygenase
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indolamine 2,3-dioxygenase
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indoleamine 2,3 dioxygenase
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indoleamine 2,3 dioxygenase
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indoleamine 2,3-dioxygenase
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indoleamine 2,3-dioxygenase
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indoleamine 2,3-dioxygenase
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657494, 657496, 660438, 696151, 696734, 696944, 697829, 698255, 698260, 698485, 698952, 699118, 699299, 699335, 699473, 699921, 699931, 700405, 701232, 701385
indoleamine 2,3-dioxygenase
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indoleamine 2,3-dioxygenase
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indoleamine 2,3-dioxygenase
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indoleamine 2,3-dioxygenase
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indoleamine 2,3-dioxygenase
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indoleamine 2,3-dioxygenase
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indoleamine 2,3-dioxygenase 1
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indoleamine 2,3-dioxygenase 1
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indoleamine 2,3-dioxygenase 1
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indoleamine 2,3-dioxygenase 2
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indoleamine 2,3-dioxygenase 2
F5H5G0
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indoleamine 2,3-dioxygenase 2
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indoleamine 2,3-dioxygenase 2
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indoleamine 2,3-dioxygenase-1
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indoleamine 2,3-dioxygenase-1
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indoleamine 2,3-dioxygenase-1
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indoleamine 2,3-dioxygenase-1
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indoleamine 2,3-dioxygenase-2
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indoleamine 2,3-dioxygenase-2
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indoleamine 2,3-dioxygenase-2
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indoleamine 2,3-dioxygenase-2
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indoleamine 2,3-dioxygenase-2
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indoleamine 2,3-dioxygenase-2
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indoleamine 2,3-dioxygenase-2
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indoleamine 2,3-dioxygenase-2
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indoleamine 2,3-dioxygenase-like protein
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indoleamine 2,3-dioxygenase-like protein
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indoleamine 2,3-dioxygenase-like protein
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indoleamine 2,3-dioxygenase-like protein
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indoleamine 2,3-dioxygenase-like protein
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proto-indoleamine 2,3-dioxygenase
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proto-indoleamine 2,3-dioxygenase
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proto-indoleamine 2,3-dioxygenase
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proto-indoleamine 2,3-dioxygenase
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proto-indoleamine 2,3-dioxygenase
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proto-indoleamine 2,3-dioxygenase
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TDO
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TDO2
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TioF
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tryptophan 2,3-dioxygenase
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tryptophan 2,3-dioxygenase
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tryptophan 2,3-dioxygenase
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tryptophan 2,3-dioxygenase
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tryptophan 2,3-dioxygenase
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three splicing variants
tryptophan 2,3-dioxygenase
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tryptophan 2,3-dioxygenase
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tryptophan 2,3-dioxygenase
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tryptophan 2,3-dioxygenase
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tryptophan 2,3-dioxygenase
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tryptophan dioxygenase
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tryptophan dioxygenase
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tryptophan dioxygenase
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tryptophan oxygenase
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1-benzofuran-DL-tryptophan + O2
?
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1 mM, 22% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
1-benzothiophene-DL-tryptophan + O2
?
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1 mM, 19% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
1-methyl-D-tryptophan + O2
N-methyl-N-formyl-D-kynurenine
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?
1-methyl-DL-tryptophan + O2
?
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1 mM, 7% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
1-methyl-L-tryptophan + O2
?
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?
1-methyl-L-tryptophan + O2
N-methyl-N-formyl-L-kynurenine
1H-indole + H2O + O2
2,3-dihydro-1H-indole-2,3-diol
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?
2-bromo-L-tryptophan + O2
?
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1 mM, 21% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
2-chloro-L-tryptophan + O2
?
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1 mM, 33% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
2-hydroxy-L-tryptophan + O2
?
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1 mM, 4% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
3-indoleethanol + O2-
?
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?
4-methyl-DL-tryptophan + O2
?
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1 mM, 33% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
5-benzyloxy-DL-tryptophan + O2
?
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1 mM, 1% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
5-bromo-DL-tryptophan + O2
?
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1 mM, 36% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
5-fluoro-DL-tryptophan + O2
5-fluoro-N-formyl-DL-kynurenine
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?
5-fluoro-DL-tryptophan + O2
?
5-fluoro-L-tryptophan + O2
5-fluoro-N-formyl-L-kynurenine
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?
5-fluoro-tryptophan + O2
4-(2-amino-5-fluorophenyl)-2-(formylamino)-4-oxobutanoic acid
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?
5-fluoro-tryptophan + O2
?
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?
5-fluorotryptophan + O2
?
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?
5-hydroxy-L-tryptophan + O2
(2S)-4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid
5-hydroxy-L-tryptophan + O2
5-hydroxy-N-formyl-L-kynurenine
5-hydroxy-L-tryptophan + O2
?
5-hydroxy-L-tryptophan + O2
N-formyl-5-hydroxy-L-kynurenine
5-hydroxy-tryptophan + O2
4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid
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?
5-hydroxytryptamine + O2
?
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?
5-hydroxytryptophan + O2
?
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?
5-hydroxytryptophan + O2-
N-formyl-5-hydroxykynurenine
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?
5-methoxy-D,L-tryptophan + O2
?
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1 mM, 70% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
5-methoxy-DL-tryptophan + O2
5-methoxy-N-formyl-DL-kynurenine
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?
5-methoxy-L-tryptophan + O2
5-methoxy-N-formyl-L-kynurenine
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?
5-methyl-D,L-tryptophan + O2
?
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1 mM, 123% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
5-methyl-DL-tryptophan + O2
5-methyl-N-formyl-DL-kynurenine
5-methyl-DL-tryptophan + O2
?
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?
5-methyl-tryptophan + O2
4-(2-amino-5-methylphenyl)-2-(formylamino)-4-oxobutanoic acid
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?
5-methyltryptophan + O2
?
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?
6-fluoro-DL-tryptophan + O2
?
6-fluorotryptophan + O2
?
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?
6-methyl-DL-tryptophan + O2
6-methyl-N-formyl-DL-kynurenine
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?
6-methyl-DL-tryptophan + O2
?
6-nitro-L-tryptophan + O2
?
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1 mM, 2% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
7-methyl-DL-tryptophan + O2
?
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1 mM, 18% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
alpha-methyl-DL-tryptophan + O2
?
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1 mM, 35% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
alpha-methyl-DL-tryptophan + O2-
?
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?
alpha-N-methyl-L-tryptophan + O2
?
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1 mM, 21% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
beta-methyl-DL-tryptophan + O2
?
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1 mM, 32% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
beta-[3-benzo(b)thienyl]-L-alanine + O2
?
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?
D-5-hydroxytryptophan + O2
?
D-Trp + O2
D-formylkynurenine
D-Trp + O2
N-formyl-D-kynurenine
D-tryptophan + O2
?
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?
D-tryptophan + O2
N-formyl-D-kynurenine
DL-5-fluoro-methyltryptophan + O2
?
DL-5-methyltryptophan + O2
?
DL-6-fluorotryptophan + O2
?
DL-alpha-methyltryptophan + O2
alpha-methyl-N-formyl-DL-kynurenine
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9.0% of the activity with L-Trp
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?
indole-3-propionic acid + O2
?
altered kinetics for IPA (very long lag phase) as being consistent with a role for the ammonium group in stabilizing the ferric superoxide complex (via the radical pathway). The rate-limiting steps are different from the other substrates examined so that Compound II does not accumulate, but product formation is still possible, product formation ananlysis by LC-MS
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?
L-5-hydroxytryptophan + O2
?
L-Trp + O2
L-formylkynurenine
L-Trp + O2
N-formyl-L-kynurenine
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?
L-tryptophan + O2
N-formyl-L-kynurenine
L-tryptophan + O2
N-formylkynurenine
L-tryptophan + O2-
N-formyl-L-kynurenine
L-tryptophan ethyl ester + O2
?
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1 mM, 14% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
L-tryptophan methyl ester + O2
?
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1 mM, 15% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
N-acetyl-L-tryptophan + O2
?
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1 mM, 3% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
serotonin + O2-
?
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?
Trp + O2
formylkynurenine
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?
tryptamine + O2-
?
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?
tryptophan + O2
N-formylkynurenine
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if the cellular environment protects indoleamine 2,3-dioxygenase from oxidation to the ferric form, no additional electron donor might by required for indolamine 2,3-dioxygenase activity in intact tissues
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?
additional information
?
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1-methyl-L-tryptophan + O2
N-methyl-N-formyl-L-kynurenine
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?
1-methyl-L-tryptophan + O2
N-methyl-N-formyl-L-kynurenine
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?
5-fluoro-DL-tryptophan + O2
?
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1 mM, 46% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
5-fluoro-DL-tryptophan + O2
?
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?
5-fluoro-DL-tryptophan + O2
?
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?
5-hydroxy-L-tryptophan + O2
(2S)-4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid
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?
5-hydroxy-L-tryptophan + O2
(2S)-4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid
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?
5-hydroxy-L-tryptophan + O2
5-hydroxy-N-formyl-L-kynurenine
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-
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?
5-hydroxy-L-tryptophan + O2
5-hydroxy-N-formyl-L-kynurenine
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?
5-hydroxy-L-tryptophan + O2
?
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-
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?
5-hydroxy-L-tryptophan + O2
?
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1 mM, 59% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
5-hydroxy-L-tryptophan + O2
N-formyl-5-hydroxy-L-kynurenine
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?
5-hydroxy-L-tryptophan + O2
N-formyl-5-hydroxy-L-kynurenine
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?
5-hydroxy-L-tryptophan + O2
N-formyl-5-hydroxy-L-kynurenine
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?
5-methyl-DL-tryptophan + O2
5-methyl-N-formyl-DL-kynurenine
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?
5-methyl-DL-tryptophan + O2
5-methyl-N-formyl-DL-kynurenine
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?
5-methyl-DL-tryptophan + O2
5-methyl-N-formyl-DL-kynurenine
high activity
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?
6-fluoro-DL-tryptophan + O2
?
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1 mM, 38% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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?
6-fluoro-DL-tryptophan + O2
?
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-
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?
6-fluoro-DL-tryptophan + O2
?
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-
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?
6-methyl-DL-tryptophan + O2
?
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1 mM, 72% activity relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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-
?
6-methyl-DL-tryptophan + O2
?
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-
-
?
D-5-hydroxytryptophan + O2
?
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-
-
-
?
D-5-hydroxytryptophan + O2
?
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enzyme from lung
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?
D-Trp + O2
D-formylkynurenine
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-
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?
D-Trp + O2
D-formylkynurenine
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?
D-Trp + O2
D-formylkynurenine
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?
D-Trp + O2
N-formyl-D-kynurenine
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?
D-Trp + O2
N-formyl-D-kynurenine
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?
D-Trp + O2
N-formyl-D-kynurenine
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-
-
?
D-Trp + O2
N-formyl-D-kynurenine
1.13.11.52 indoleamine 2,3-dioxygenase
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