show all | hide all No of entries

Information on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

for references in articles please use BRENDA:EC1.13.11.52
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase . It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver . While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan [2,6]. Superoxide radicals can replace O2 as oxygen donor [4,7].
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
indoleamine-2,3-dioxygenase, tryptophan pyrrolase, tryptophan oxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase-1, tryptophan dioxygenase, indolamine 2,3-dioxygenase, l-tryptophan 2,3-dioxygenase, hido1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-tryptophan + O2 = N-formyl-D-kynurenine
show the reaction diagram
-
-
-
-
L-tryptophan + O2 = N-formyl-L-kynurenine
show the reaction diagram