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Information on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

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IUBMB Comments

A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase . It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver . While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan [2,6]. Superoxide radicals can replace O2 as oxygen donor [4,7].

The enzyme appears in viruses and cellular organisms

Synonyms
indoleamine 2,3-dioxygenase, indoleamine-2,3-dioxygenase, tryptophan pyrrolase, tryptophan oxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase-1, indolamine 2,3-dioxygenase, tryptophan dioxygenase, hido1, indoleamine-pyrrole 2,3-dioxygenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-tryptophan + O2 = N-formyl-D-kynurenine
show the reaction diagram
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L-tryptophan + O2 = N-formyl-L-kynurenine
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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