Literature summary for 1.14.16.4 extracted from

Pennati, R.; Candiani, S.; Biggiogero, M.; Zega, G.; Groppelli, S.; Oliveri, D.; Parodi, M.; De Bernardi, F.; Pestarino, M.
Developmental expression of tryptophan hydroxylase gene in Ciona intestinalis (2007), Dev. Genes Evol., 217, 307-313.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene tph, DNA and amino acid sequence deterination and analysis, expression analysis, phylogenetic analysis	Ciona intestinalis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	Ciona intestinalis	rate-limiting enzyme in serotonin synthesis	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Ciona intestinalis	A1Y9J6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
larva	TPH expression pattern during development, TPH expression was found from tailbud stage in the precursor cells of the visceral ganglion and in the tail	Ciona intestinalis	-
neuron	TPHexpressing neurons form two clusters in the anterior central nervous system at the level of the visceral ganglion	Ciona intestinalis	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	-	Ciona intestinalis	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	rate-limiting enzyme in serotonin synthesis	Ciona intestinalis	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
TPH	-	Ciona intestinalis
tryptophan hydroxylase	-	Ciona intestinalis

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Release 2023.1 (January 2023)