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Literature summary for 1.14.16.4 extracted from

  • Scheuch, K.; Lautenschlager, M.; Grohmann, M.; Stahlberg, S.; Kirchheiner, J.; Zill, P.; Heinz, A.; Walther, D.J.; Priller, J.
    Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons (2007), Biol. Psychiatry, 62, 1288-1294.
    View publication on PubMed
Search for more literature for 1.14.16.4

Protein Variants

Protein Variants Comment Organism
additional information polymorphism rs11178997 of the TPH2 promoter significantly reduces TPH2 transcriptional activity by 22% in primary serotonergic neurons. In contrast, no significant differences in promoter activity are observed for the G- and T-alleles of rs4570625. Reduced binding of the transcription factor POU3F2, i.e. Brn-2 or N-Oct-3, to the A-allele occur with the polymorphism rs11178997, while overexpression of POU3F2 results in a robust activation of the TPH2 promoter by about 2.7fold. The human TPH2 promoter is active in rat serotonergic raphe neurons Rattus norvegicus
additional information polymorphism rs11178997 of the TPH2 promoter significantly reduces TPH2 transcriptional activity by 7% in SHP-77 cells. In contrast, no significant differences in promoter activity are observed for the G- and T-alleles of rs4570625. Reduced binding of the transcription factor POU3F2, i.e. Brn-2 or N-Oct-3, to the A-allele occur with the polymorphism rs11178997, while overexpression of POU3F2 results in a robust activation of the TPH2 promoter by about 2.7fold, functional assays of TPH2 regulatory region variants, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 Rattus norvegicus TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes TPH1 and TPH2
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Rattus norvegicus Q8CGU9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain raphe nuclei Rattus norvegicus
-
neuron primary serotonergic, from raphe nuclei Rattus norvegicus
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SHP-77 cell human small cell lung carcinoma cell line, SHP-77 cells preferentially express TPH1 over TPH2 mRNA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2
-
 Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Synonyms

Synonyms Comment Organism
TPH1
-
 Homo sapiens
TPH2
-
 Homo sapiens
TPH2
-
 Rattus norvegicus
tryptophan hydroxylase 2
-
 Homo sapiens
tryptophan hydroxylase 2
-
 Rattus norvegicus