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BRENDA support

Information on EC 1.3.1.72 - DELTA24-sterol reductase

for references in articles please use BRENDA:EC1.3.1.72

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IUBMB Comments

Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
dhcr24, seladin-1, dwarf1, 24-dehydrocholesterol reductase, 24-reductase, dehydrocholesterol reductase, diminuto/dwarf1, delta24-reductase, zmdwf1, desmosterol reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5alpha-cholest-7-en-3beta-ol + NADP+ = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
cholesterol biosynthesis (algae, late side-chain reductase), cholesterol biosynthesis (diatoms), cholesterol biosynthesis (plants, early side-chain reductase), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), sterol biosynthesis (methylotrophs)