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Information on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase

for references in articles please use BRENDA:EC1.1.1.270

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IUBMB Comments

The enzyme acts on multiple 3β-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17β-estradiol 17-dehydrogenase .

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
3beta-hydroxysteroid dehydrogenase, hsd3b1, akr1c2, hsd17b7, erg27, 3beta-hsd1, 3-ketosteroid reductase, 3beta-hsd2, 3-ketoreductase, erg27p, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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