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Information on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase

for references in articles please use BRENDA:EC1.1.1.270
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IUBMB Comments
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
3beta-hydroxysteroid dehydrogenase, akr1c2, hsd17b7, 3beta-hsd1, erg27, 3-ketosteroid reductase, 3beta-hsd2, 3-ketoreductase, erg27p, akr1cs, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+
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