Protein Variants | Comment | Organism |
---|---|---|
F279S | mutation identified in patients with X-linked mental retardation. abolishes catalytic activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | P0CH95 | - |
- |
Homo sapiens | Q9UPP1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
jaw | - |
Danio rerio | - |
neuron | - |
Danio rerio | - |
U2-OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Danio rerio | a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Danio rerio | a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
additional information | enzyme acts additionally as mono-methyl histone H4 lysine 20 demethylase | Homo sapiens | ? | - |
? | |
additional information | enzyme acts additionally as mono-methyl histone H4 lysine 20 demethylase | Danio rerio | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone lysine demethylase | - |
Danio rerio |
PHF8 | - |
Homo sapiens |
PHF8 | - |
Danio rerio |
General Information | Comment | Organism |
---|---|---|
physiological function | PHF8 over-expression in U2OS but not HeLa cells results in a significant reduction of H3K9me2 level and only a slight reduction of the global level of H4K20me1 | Homo sapiens |
physiological function | PHF8 regulates cell survival in the zebrafish developing brain and jaw development. In a model PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB | Danio rerio |