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Information on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase

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IUBMB Comments
A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).
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The enzyme appears in viruses and cellular organisms
Synonyms
selenoprotein p, phgpx, glutathione peroxidase 4, phospholipid hydroperoxide glutathione peroxidase, gpx-4, glutathione peroxidase-4, npgpx, selenoperoxidase, gpx4b, gpx4a, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
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