Reference on EC 4.6.1.1 - adenylate cyclase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Masure, H.R.; Storm, D.R.
Characterization of the bacterial cell associated calmodulin-sensitive adenylate cyclase from Bordetella pertussis
Biochemistry
28
438-442
1989
Bordetella pertussis
Rogel, A.; Farfel, Z.; Goldschmidt, S.; Shiloach, J.; Hanski, E.
Bordetella pertussis adenylate cyclase. Identification of multiple forms of the enzyme by antibodies
J. Biol. Chem.
263
13310-13316
1988
Bordetella pertussis
Carricarte, V.C.; Bianchini, G.M.; Muschietti, J.P.; Tellez-Inon, M.T.; Perticari, A.; Torres, N.; Flawia, M.M.
Adenylate cyclase activity in a higher plant, alfalfa (Medicago sativa)
Biochem. J.
249
807-811
1988
Bordetella pertussis, Medicago sativa
Ladant, D.; Brezin, C.; Alonso, J.M.; Crenon, I.; Guiso, N.
Bordetella pertussis adenylate cyclase. Purification, characterization, and radioimmunoassay
J. Biol. Chem.
261
16264-16269
1986
Bordetella pertussis
Kessin, R.H.; Franke, J.
Secreted adenylate cyclase of Bordetella pertussis: calmodulin requirements and partial purification of two forms
J. Bacteriol.
166
290-296
1986
Bordetella pertussis
Shattuck, R.L.; Oldenburg, D.J.; Storm, D.R.
Purification and characterization of a calmodulin-sensitive adenylate cyclase from Bordetella pertussis
Biochemistry
24
6356-6362
1985
Bordetella pertussis, Bos taurus
Jayaswal, R.K.; Bressan, R.A.; Handa, A.K.
Adenylate cyclase form the phytopathogenic fungus Alternaria solani
FEMS Microbiol. Lett.
27
313-318
1985
Alternaria solani
-
Yeager, R.E.; Heideman, W.; Rosenberg, G.B.; Storm, D.R.
Purification of the calmodulin-sensitive adenylate cyclase from bovine cerebral cortex
Biochemistry
24
3776-3783
1985
Bos taurus
Wolff, J.; Cook, G.H.
Microtubule-associated adenylate cyclase
Biochim. Biophys. Acta
844
34-41
1985
Bos taurus
Schultz, J.E.; Klumpp, S.
Adenylate cyclase in cilia from Paramecium
FEBS Lett.
154
347-350
1983
Paramecium tetraurelia
-
Yang, J.K.; Epstein, W.
Purification and characterization of adenylate cyclase from Escherichia coli K12
J. Biol. Chem.
258
3750-3758
1983
Glutamicibacter nicotianae, Escherichia coli
Rosenberg, G.B.; Pall, M.L.
Characterization of an ATP-Mg2+-dependent guanine nucleotide-stimulated adenylate cyclase from Neurospora crassa
Arch. Biochem. Biophys.
221
243-253
1983
Neurospora crassa
Reig, J.A.; Kornbliht, A.R.; Flawia, M.M.; Torres, H.N.
Soluble adenylate cyclase activity in Neurospora crassa
Biochem. J.
207
43-49
1982
Neurospora crassa
Cantore, M.L.; Passeron, S.
Kinetic properties, solubilization, and molecular characterization of Mucor rouxii adenylate cyclase
Arch. Biochem. Biophys.
219
1-11
1982
Amylomyces rouxii
De Vries, G.W.; Ferrendelli, J.A.
Characterization and localization of adenylate and guanylate cyclases
Methods Enzymol.
81
517-522
1982
squirrel
Kornblihtt, A.R.; Flawia, M.M.; Torres, H.N.
Manganese ion dependent adenylate cyclase activity in rat testes: purification and properties
Biochemistry
20
1262-1267
1981
Rattus norvegicus
Janecek, J.; Naprstek, J.; Dobrova, Z.; Jiresova, M.; Spizek, J.
Characterization of adenylate cyclase from Escherichia coli
Folia Microbiol. (Praha)
25
361-368
1980
Glutamicibacter nicotianae, Escherichia coli
Cohen, R.J.; Ness, J.L.; Whiddon, S.M.
Adenylate cyclase from Phycomyces sporangiophore
Phytochemistry
19
1913-1918
1980
Phycomyces blakesleeanus
-
Dessauer, C.W.; Gilman, A.G.
Purification and characterization of a soluble form of mammalian adenylyl cyclase
J. Biol. Chem.
271
16967-16974
1996
Mammalia
Read, L.K.; Mikkelsen, R.B.
Plasmodium falciparum-infected erythrocytes contain an adenylate cyclase with properties which differ from those of the host enzyme
Mol. Biochem. Parasitol.
45
109-120
1991
Homo sapiens, Plasmodium falciparum
Rodan, S.B.; Egan, J.J.; Golub, E.E.; Rodan, G.A.
Comparison of bone and osteosarcoma adenylate cyclase. Partial purification of membranes and kinetic properties of enzyme
Biochem. J.
185
617-627
1980
Rattus norvegicus
Stengel, D.; Hanoune, J.
Solubilization and physical characterization of the adenylate cyclase from rat-liver plasma membranes
Eur. J. Biochem.
102
21-34
1979
Rattus norvegicus
Gidwitz, S.; Toscano, W.A.; Toscano, D.G.; Weber, M.J.; Storm, D.R.
A comparison between adenylate cyclase solubilized from normal and Rous sarcoma virus-transformed chicken embryo fibroblasts
Biochim. Biophys. Acta
627
1-16
1980
Gallus gallus
Martin, B.R.; Voorheis, H.P.; Kenedy, E.L.
Adenylate cyclase in bloodstream forms of Trypanosoma (Trypanozoon) brucei sp.
Biochem. J.
175
207-212
1978
Trypanosoma brucei
Morishima, I.
Adenylate cyclase in silkworm. Properties of the enzyme in pupal fat body
J. Biochem.
84
1495-1500
1978
Bombyx mori
Neer, E.J.
Physical and functional properties of adenylate cyclase from mature rat testis
J. Biol. Chem.
253
5808-5812
1978
Rattus norvegicus
Asbury, R.F.; Cook, G.H.; Wolff, J.
Soluble adenylate cyclase from thyroid membranes
J. Biol. Chem.
253
5286-5292
1978
Bos taurus
Reddy, N.B.; Oliver, K.L.; Festoff, B.W.; Engel, W.K.
Adenylate cyclase system of human skeletal muscle subcellular distribution and general problems
Biochim. Biophys. Acta
540
371-388
1978
Homo sapiens
-
Forsyth, G.W.; Hamilton, D.L.; Goertz, K.E.; Oliphant, L.W.
Some comparative properties and localization of porcine jejunal adenylate cyclase
Can. J. Biochem.
56
280-286
1978
Sus scrofa
Deschodt-Lanckman, M.; Robberecht, P.; Christophe, J.
Characterization of VIP-sensitive adenylate cyclase in guinea pig brain
FEBS Lett.
83
76-80
1977
Cavia porcellus
Wedner, H.J.; Parker, C.W.
Adenylate cyclase activity in lymphocyte subcellular fractions. Characterization of a nuclear adenylate cyclase
Biochem. J.
162
483-491
1977
Homo sapiens
Braun, T.
Purification of soluble form of adenylyl cyclase from testes
Methods Enzymol.
195
130-136
1991
Rattus norvegicus
Varimo, K.; Londesborough, J.
Solubilization and other studies on adenylate cyclase of baker s yeast
Biochem. J.
159
363-370
1976
Saccharomyces cerevisiae
Herman, C.A.; Zahler, W.L.; Doak, G.A.; Campbell, B.J.
Bull sperm adenylate cyclase: localization and partial characterization
Arch. Biochem. Biophys.
177
622-629
1976
Bos taurus
Pfeuffer, E.; Mollner, S.; Pfeuffer, T.
Purification of adenylyl cyclase from heart and brain
Methods Enzymol.
195
83-91
1991
Oryctolagus cuniculus
Venter, C.; Kaplan, N.O.
A partial purification of the beta-adrenergic receptor adenylate cyclase complex by affinity chromatography to glass bead-immobilized isoproterenol
Methods Enzymol.
38C
187-191
1974
Meleagris gallopavo
-
Tao, M.
Preparation and properties of adenylate cyclase from Escherichia coli
Methods Enzymol.
38C
155-160
1974
Glutamicibacter nicotianae, Escherichia coli
Drummond, G.I.; Severson, D.L.
Preparation and characterization of adenylate cyclase from heart and skeletal muscle
Methods Enzymol.
38C
143-149
1974
Cavia porcellus, Oryctolagus cuniculus
Neer, E.J.
The size of adenylate cyclase
J. Biol. Chem.
249
6527-6531
1974
Rattus norvegicus
Takai, K.; Kurashina, Y.; Suzuki-Hori, C.; Okamoto, H.; Hayaishi, O.
Adenylate cyclase from Brevibacterium liquefaciens. I. Purification, crystallization, and some properties
J. Biol. Chem.
249
1965-1972
1974
Glutamicibacter nicotianae
Hellevuo, K.; Yoshimura, M.; Mons, N.; Hoffman, P.L.; Cooper, D.M.F.; Tabakoff, B.
The characterization of a novel human adenylyl cyclase which is present in brain and other tissues
J. Biol. Chem.
270
11581-11589
1995
Homo sapiens
Watson, P.A.; Krupinski, J.; Kempinski, A.M.; Frankenfeld, C.D.
Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells
J. Biol. Chem.
269
28893-28898
1994
Mus musculus
Dessauer, C.W.; Gilman, A.G.
The catalytic mechanism of mammalian adenylyl cyclase. Equilibrium binding and kinetic analysis of P-site inhibition
J. Biol. Chem.
272
27787-27795
1997
Mammalia
Wei, J.; Wayman, G.; Storm, D.R.
Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo
J. Biol. Chem.
271
24231-24235
1996
Mammalia
Gentile, F.; Knipling, L.G.; Sackett, D.L.; Wolff, J.
Invasive adenylyl cyclase of Bordetella pertussis. Physical, catalytic, and toxic properties
J. Biol. Chem.
265
10686-10692
1990
Bordetella pertussis
Yoshimura, M.; Cooper, D.M.F.
Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells
Proc. Natl. Acad. Sci. USA
89
6716-6720
1992
Mammalia
Feinstein, P.G.; Schrader, K.A.; Bakalyar, H.A.; Tang, W-J.; Krupinski, J.; Gilman, A.G.; Reed, R.R.
Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain
Proc. Natl. Acad. Sci. USA
88
10173-10177
1991
Rattus norvegicus
Tang, W.J.; Krupinski, J.; Gilman, A.G.
Expression and characterization of calmodulin-activated (type I) adenylylcyclase
J. Biol. Chem.
266
8595-8603
1991
Bos taurus
Dieudonne, M.N.; Pequery, R.; Giudicelli, Y.
Characteristics of the alpha 2/beta-adrenoceptor-coupled adenylate cyclase system and their relationship with adrenergic responsiveness in hamster fat cells from different anatomical sites
Eur. J. Biochem.
205
867-873
1992
Mesocricetus auratus
Munier, H.; Gilles, A.M.; Glaser, P.; Krin, E.; Danchin, A.; Sarfati, R.; Barzu, O.
Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase
Eur. J. Biochem.
196
469-474
1991
Bordetella pertussis
Iourgenko, V.; Kliot, B.; Cann, M.J.; Levin, L.R.
Cloning and characterization of a Drosophila adenylyl cyclase homologous to mammalian type IX
FEBS Lett.
413
104-108
1997
Drosophila melanogaster
Kawabe, J.I.; Toya, Y.; Schencke, C.; Oka, N.; Ebina, T.; Ishikawa, Y.
Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells. Purification and biochemical characterization
J. Biol. Chem.
271
20132-20137
1996
Spodoptera frugiperda
Sismeiro, O.; Trotot, P.; Bibille, F.; Vivares, C.; Danchin, A.
Aeromonas hydrophila adenylyl cyclase 2: a new class of adenylyl cyclases with thermophilic properties and sequence similarities to proteins from hyperthermophilic archaebacteria
J. Bacteriol.
180
3339-3344
1998
Aeromonas hydrophila (Q59119), Aeromonas hydrophila
Premont, R.T.; Matsuoka, I.; Mattei, M.G.; Pouille, Y.; Defer, N.; Hanoune, J.
Identification and characterization of a widely expressed form of adenylyl cyclase
J. Biol. Chem.
271
13900-13907
1996
Mus musculus (P51830), Mus musculus, Rattus norvegicus
Sethi, R.; Dhalla, K.S.; Shah, K.R.; Dhalla, N.S.
Characterization of adenylyl cyclase in heart sarcolemma in the absence or presence of alamethicin
Mol. Cell. Biol.
119
185-193
1993
Rattus norvegicus
Plesneva, S.A.; Nalivaeva, N.N.; Zhuravin, I.A.
Adenylate cyclase system of the rat striatum: regulatory properties and the effects of gangliosides
Neurosci. Behav. Physiol.
28
392-396
1998
Rattus norvegicus
Masure, H.R.; Shattuck, R.L.; Storm, D.R.
Mechanisms of bacterial pathogenicity that involve production of calmodulin-sensitive adenylate cyclases
Microbiol. Rev.
51
60-65
1987
Bordetella pertussis
Masure, H.R.; Oldenburg, D.J.; Donovan, M.G.; Shattuck, R.L.; Storm, D.R.
The interaction of Ca2+ with the calmodulin-sensitive adenylate cyclase from Bordetella pertussis
J. Biol. Chem.
263
6933-6940
1988
Bordetella pertussis
Wolff, J.; Cook, G.H.; Goldhammer, A.R.; Berkkowitz, S.A.
Calmodulin activates prokaryotic adenylate cyclase
Proc. Natl. Acad. Sci. USA
77
3841-3844
1980
Bordetella pertussis
Ide, M.
Adenyl cyclase of bacteria
Arch. Biochem. Biophys.
144
262-268
1971
Alcaligenes faecalis, Arthrobacter citreus, Arthrobacter globiformis, Glutamicibacter nicotianae, Rhodococcus equi, Escherichia coli, Pectobacterium carotovorum, Micrococcus flavus, Micrococcus luteus, Nocardia erythropolis
-
Reddy, P.; Peterkofsky, A.; McKenney, K.
Hyperexpression and purification of Escherichia coli adenylate cyclase using a vector designed for expression of lethal gene products
Nucleic Acids Res.
17
10473-10488
1989
Escherichia coli
Moos Jr., M.; Morris, D.I.; Robbins, J.; Appel, L.; Seamon, K.B.
Purification of bovine brain adenylyl cyclase with a novel derivative of forskolin: evidence for a high specific activity form of the enzyme
Prep. Biochem. Biotechnol.
26
155-167
1996
Bos taurus
Enomoto, L.; Takano, M.; Ariyoshi, S.; Asakawa, T.
Mechanism and properties of inhibition of purified rat brain adenylate cyclase by G protein beta gamma-subunits
Jpn. J. Pharmacol.
69
239-250
1995
Rattus norvegicus
Kirkham, D.M.; Henley, J.M.
Characterization of adenylyl cyclase in goldfish brain
Biochem. Pharmacol.
46
1559-1563
1993
Carassius auratus
Colvin, R.A.; Oibo, J.A.; Allen, R.A.
Calcium inhibition of cardiac adenylyl cyclase. Evidence for two distinct sites of inhibition
Cell Calcium
12
19-27
1991
Canis lupus familiaris
Glaser, P.; Landant, D.; Sezer, O.; Pichot, F.; Ullmann, A.; Danchin, A.
The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia coli
Mol. Microbiol.
2
19-30
1988
Bordetella pertussis
Pozo, D.; Segura, J.J.; Carrero, I.; Guijarro, L.G.; Prieto, J.C.; Calvo, J.R.
Characterization of adenylyl cyclase stimulated by VIP in rat and mouse peritoneal macrophage membranes
Biochim. Biophys. Acta
1312
249-254
1996
Mus musculus, Rattus norvegicus
Nair, B.G.; Patel, T.B.
Inhibition of hepatic adenylate cyclase by NADH
Life Sci.
49
915-923
1991
Rattus norvegicus
Khan, N.A.; Quemener, V.; Moulinoux, J.P.
Inhibition of adenylate cyclase activity by polyamines in human erythrocyte plasma membranes
Life Sci.
46
43-47
1990
Homo sapiens
Crasnier, M.; Danchin, A.
Characterization of Escherichia coli adenylate cyclase mutants with modified regulation
J. Gen. Microbiol.
136
1825-1831
1990
Escherichia coli
Wadman, I.A.; Farndale, R.W.; Martin, B.R.
Evidence for regulation of human platelet adenylate cyclase by phosphorylation. Inhibition by ATP and guanosine 5 -[beta-thio]diphosphate occur by distinct mechanisms
Biochem. J.
276
621-630
1991
Homo sapiens
Wang, P.; Storm, D.R.
Purification and characterization of calmodulin-sensitive adenylyl cyclase from bovine brain
Methods Enzymol.
195
65-82
1991
Bos taurus
Bieger, B.; Essen, L.O.
Crystallization and preliminary X-ray analysis of the catalytic domain of the adenylate cyclase GRESAG4.1 from Trypanosoma brucei
Acta Crystallogr. Sect. D
56
359-362
2000
Trypanosoma brucei
Defer, N.; Best-Belpomme, M.; Hanoune, J.
Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase
Am. J. Physiol.
279
F400-F416
2000
Gallus gallus, Mus musculus, Rattus norvegicus
Hanoune, J.; Defer, N.
Regulation and role of adenylyl cyclase isoforms
Annu. Rev. Pharmacol. Toxicol.
41
145-174
2001
Homo sapiens
Jasso-Chavez, R.; Vega-Segura, A.; El-Hafidi, M.; Moreno-Sanchez, R.; Torres-Marquez, M.E.
Kinetic and thermodynamic characterization of adenylyl cyclase from Euglena gracilis
Arch. Biochem. Biophys.
404
48-54
2002
Euglena gracilis
Weber, J.H.; Vishnyakov, A.; Hambach, K.; Schultz, A.; Schultz, J.E.; Linder, J.U.
Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins
Cell. Signal.
16
115-125
2003
Tetrahymena pyriformis (Q8I0I1), Paramecium tetraurelia (Q8I759), Plasmodium falciparum (Q8I7A1), Plasmodium falciparum
Kanacher, T.; Schultz, A.; Linder, J.U.; Schultz, J.E.
A GAF-domain-regulated adenylyl cyclase from Anabaena is a self-activating cAMP switch
EMBO J.
21
3672-3680
2002
Anabaena sp. (P94181)
Gallay, J.; Vincent, M.; Li de la Sierra, I.M.; Munier-Lehmann, H.; Renouard, M.; Sakamoto, H.; Barzu, O.; Gilles, A.M.
Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy
Eur. J. Biochem.
271
821-833
2004
Bordetella pertussis
Shenoy, A.R.; Srinivasan, N.; Subramaniam, M.; Visweswariah, S.S.
Mutational analysis of the Mycobacterium tuberculosis Rv1625c adenylyl cyclase: residues that confer nucleotide specificity contribute to dimerization
FEBS Lett.
545
253-259
2003
Mycobacterium tuberculosis
Dumortier, F.; Vanhalewyn, M.; Debast, G.; Colombo, S.; Ma, P.; Winderickx, J.; Van Dijck, P.; Thevelein, J.M.
A specific mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K1876M, eliminates glucose- and acidification-induced cAMP signalling and delays glucose-induced loss of stress resistance
Int. J. Food Microbiol.
55
103-107
2000
Saccharomyces cerevisiae
Tellez-Sosa, J.; Soberon, N.; Vega-Segura, A.; Torres-Marquez, M.E.; Cevallos, M.A.
The Rhizobium etli cyaC product: characterization of a novel adenylate cyclase class
J. Bacteriol.
184
3560-3568
2002
Rhizobium etli (Q8KY20), Rhizobium etli
McVey, M.; Hill, J.; Howlett, A.; Klein, C.
Adenylyl cyclase, a coincidence detector for nitric oxide
J. Biol. Chem.
274
18887-18892
1999
Homo sapiens
Kasahara, M.; Unno, T.; Yashiro, K.; Ohmori, M.
CyaG, a novel cyanobacterial adenylyl cyclase and a possible ancestor of mammalian guanylyl cyclases
J. Biol. Chem.
276
10564-10569
2001
Arthrospira platensis (Q9EXQ2), Arthrospira platensis
Jaiswal, B.S.; Conti, M.
Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase
J. Biol. Chem.
276
31698-31708
2001
Mus musculus, Rattus norvegicus
Reddy, S.K.; Kamireddi, M.; Dhanireddy, K.; Young, L.; Davis, A.; Reddy, P.T.
Eukaryotic-like adenylyl cyclases in Mycobacterium tuberculosis H37Rv: cloning and characterization
J. Biol. Chem.
276
35141-35149
2001
Mycobacterium tuberculosis (P9WQ35), Mycobacterium tuberculosis H37Rv (P9WQ35), Mycobacterium tuberculosis H37Rv
Lawrence, A.J.; Coote, J.G.; Kazi, Y.F.; Lawrence, P.D.; MacDonald-Fyall, J.; Orr, B.M.; Parton, R.; Riehle, M.; Sinclair, J.; Young, J.; Price, N.C.
A direct pyrophosphatase-coupled assay provides new insights into the activation of the secreted adenylate cyclase from Bordetella pertussis by calmodulin
J. Biol. Chem.
277
22289-22296
2002
Bordetella pertussis
D'Angelo, M.A.; Montagna, A.E.; Sanguineti, S.; Torres, H.N.; Flawia, M.M.
A Novel Calcium-stimulated Adenylyl Cyclase from Trypanosoma cruzi, Which Interacts with the Structural Flagellar Protein Paraflagellar Rod
J. Biol. Chem.
277
35025-35034
2002
Trypanosoma cruzi (O77079), Trypanosoma cruzi
Litvin, T.N.; Kamenetsky, M.; Zarifyan, A.; Buck, J.; Levin, L.R.
Kinetic Properties of "Soluble" Adenylyl Cyclase. Synergism between calcium and bicarbonate
J. Biol. Chem.
278
15922-15926
2003
Homo sapiens
Muhia, D.K.; Swales, C.A.; Eckstein-Ludwig, U.; Saran, S.; Polley, S.D.; Kelly, J.M.; Schaap, P.; Krishna, S.; Baker, D.A.
Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum
J. Biol. Chem.
278
22014-22022
2003
Plasmodium falciparum (Q7Z1B9), Plasmodium falciparum
Baker, L.P.; Nielsen, M.D.; Impey, S.; Hacker, B.M.; Poser, S.W.; Chan, M.Y.M.; Storm, D.R.
Regulation and immunohistochemical localization of bg-stimulated adenylyl cyclases in mouse hippocampus
J. Neurosci.
19
180-192
1999
Mus musculus
Cumbay, M.G.; Watts, V.J.
Novel Regulatory Properties of Human Type 9 Adenylate Cyclase (AC9)
J. Pharmacol. Exp. Ther.
310
108-115
2004
Homo sapiens
Tada, T.; Sekimoto, H.; Ohmori, M.
Biochemical characterization of an adenylate cyclase, CyaB1, in the cyanobacterium Anabaena sp. strain PCC 7120
J. Plant Res.
114
387-394
2001
Anabaena sp.
-
Hatley, M.E.; Gilman, A.G.; Sunahara, R.K.
Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases
Methods Enzymol.
345
127-140
2001
Canis lupus familiaris, Rattus norvegicus
Rhee, M.H.; Nevo, I.; Avidor-Reiss, T.; Levy, R.; Vogel, Z.
Differential superactivation of adenylyl cyclase isozymes after chronic activation of the CB1 cannabinoid receptor
Mol. Pharmacol.
57
746-752
2000
Homo sapiens
Bernatchez, R.; Belkacemi, L.; Rassart, E.; Daoud, G.; Simoneau, L.; Lafond, J.
Differential expression of membrane and soluble adenylyl cyclase isoforms in cytotrophoblast cells and syncytiotrophoblasts of human placenta
Placenta
24
648-657
2003
Homo sapiens, Homo sapiens (O43306), Homo sapiens (O60266), Homo sapiens (O95622), Homo sapiens (P40145), Homo sapiens (P51828), Homo sapiens (Q08462), Homo sapiens (Q08828), Homo sapiens (Q96PN6)
Buck, J.; Sinclair, M.L.; Schapal, L.; Cann, M.J.; Levin, L.R.
Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals
Proc. Natl. Acad. Sci. USA
96
79-84
1999
Rattus norvegicus (Q9Z286)
Asboth, G.; Price, S.A.; Bellinger, J.; Ledger, W.; Barlow, D.H.; Bernal, A.L.
Characterization of adenylyl cyclases in cultured human granulosa cells
Reproduction
121
217-228
2001
Homo sapiens
Tesmer, J.J.G.; Sunahara, R.K.; Johnson, R.A.; Gosselin, G.; Gilman, A.G.; Sprang, S.R.
Two-metal-ion catalysis in adenylyl cyclase
Science
285
756-760
1999
Rattus norvegicus
Fabbri, E.; Capuzzo, A.
Adenylyl cyclase activity and its modulation in the gills of Mytilus galloprovincialis exposed to Cr6+ and Cu2+
Aquat. Toxicol.
76
59-68
2006
Mytilus galloprovincialis
Gupta, M.; Alam, S.; Bhatnagar, R.
Kinetic characterization and ligand binding studies of His351 mutants of Bacillus anthracis adenylate cyclase
Arch. Biochem. Biophys.
446
28-34
2006
Bacillus anthracis
Gille, A.; Guo, J.; Mou, T.C.; Doughty, M.B.; Lushington, G.H.; Seifert, R.
Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5'-triphosphates, nucleoside 5'-[g-thio]triphosphates and nucleoside 5'-[b,g-imido]triphosphates
Biochem. Pharmacol.
71
89-97
2005
Mus musculus
Jaleel, M.; Shenoy, A.R.; Visweswariah, S.S.
Tyrphostins Are Inhibitors of Guanylyl and Adenylyl Cyclases
Biochemistry
43
8247-8255
2004
Homo sapiens
Shenoy, A.R.; Srinivas, A.; Mahalingam, M.; Visweswariah, S.S.
An adenylyl cyclase pseudogene in Mycobacterium tuberculosis has a functional ortholog in Mycobacterium avium
Biochimie
87
557-563
2005
Mycobacterium avium (Q5UFR5), Mycobacterium avium, Mycobacterium avium TN104 (Q5UFR5)
Masuda, S.; Ono, T.a.
Biochemical characterization of the major adenylyl cyclase, Cya1, in the cyanobacterium Synechocystis sp. PCC 6803
FEBS Lett.
577
255-258
2004
Synechocystis sp. PCC 6803
Siegel, L.S.; Hylemon, P.B.; Phibbs, P.V., Jr.
Cyclic adenosine 3',5'-monophosphate levels and activities of adenylate cyclase and cyclic adenosine 3',5'-monophosphate phosphodiesterase in Pseudomonas and Bacteroides
J. Bacteriol.
129
87-96
1977
no activity in Bacteroides fragilis
Masuda, S.; Ono, T.a.
Adenylyl cyclase activity of Cya1 from the cyanobacterium Synechocystis sp. strain PCC 6803 is inhibited by bicarbonate
J. Bacteriol.
187
5032-5035
2005
Synechocystis sp.
Guo, Q.; Shen, Y.; Zhukovskaya, N.L.; Florian, J.; Tang, W.J.
Structural and Kinetic Analyses of the Interaction of Anthrax Adenylyl Cyclase Toxin with Reaction Products cAMP and Pyrophosphate
J. Biol. Chem.
279
29427-29435
2004
Bacillus anthracis
Iwatsubo, K.; Minamisawa, S.; Tsunematsu, T.; Nakagome, M.; Toya, Y.; Tomlinson, J.E.; Umemura, S.; Scarborough, R.M.; Levy, D.E.; Ishikawa, Y.
Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration
J. Biol. Chem.
279
40938-40945
2004
Mus musculus
Chen-Goodspeed, M.; Lukan, A.N.; Dessauer, C.W.
Modeling of Gas and Gai Regulation of Human Type V and VI Adenylyl Cyclase
J. Biol. Chem.
280
1808-1816
2005
Homo sapiens
Steegborn, C.; Litvin, T.N.; Hess, K.C.; Capper, A.B.; Taussig, R.; Buck, J.; Levin, L.R.; Wu, H.
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen
J. Biol. Chem.
280
31754-31759
2005
Homo sapiens, Arthrospira platensis
Mou, T.C.; Gille, A.; Fancy, D.A.; Seifert, R.; Sprang, S.R.
Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-methylanthraniloyl)-guanosine 5 '-triphosphate
J. Biol. Chem.
280
7253-7261
2005
Mammalia
Valbonesi, P.; Caselli, F.; Capuzzo, A.; Fabbri, E.
Modulation of adenyl cyclase activity in the gills of Tapes philippinarum
J. Exp. Zool. A
301
952-960
2004
Ruditapes philippinarum
Ketkar, A.D.; Shenoy, A.R.; Ramagopal, U.A.; Visweswariah, S.S.; Suguna, K.
A Structural Basis for the Role of Nucleotide Specifying Residues in Regulating the Oligomerization of the Rv1625c Adenylyl Cyclase from M. tuberculosis
J. Mol. Biol.
356
904-916
2006
Mycobacterium tuberculosis (P9WQ35), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ35)
Yahr, T.L.; Vallis, A.J.; Hancock, M.K.; Barbieri, J.T.; Frank, D.W.
ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system
Proc. Natl. Acad. Sci. USA
95
13899-13904
1998
Pseudomonas aeruginosa
Tews, I.; Findeisen, F.; Sinning, I.; Schultz, A.; Schultz, J.E.; Linder, J.U.
The Structure of a pH-Sensing Mycobacterial Adenylyl Cyclase Holoenzyme
Science
308
1020-1023
2005
Mycobacterium tuberculosis (P9WQ35), Mycobacterium tuberculosis H37Rv (P9WQ35)
Smith, N.; Kim, S.K.; Reddy, P.T.; Gallagher, D.T.
Crystallization of the class IV adenylyl cyclase from Yersinia pestis
Acta Crystallogr. Sect. F
62
200-204
2006
Yersinia pestis
Yoshimura, M.; Pearson, S.; Kadota, Y.; Gonzalez, C.E.
Identification of ethanol responsive domains of adenylyl cyclase
Alcohol. Clin. Exp. Res.
30
1824-1832
2006
Rattus norvegicus (P21932), Rattus norvegicus (P26769), Homo sapiens (P51828)
Paunescu, T.G.; Da Silva, N.; Russo, L.M.; McKee, M.; Lu, H.A.; Breton, S.; Brown, D.
Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells
Am. J. Physiol. Renal Physiol.
294
F130-F138
2008
Mus musculus, Rattus norvegicus
Beltran, C.; Vacquier, V.D.; Moy, G.; Chen, Y.; Buck, J.; Levin, L.R.; Darszon, A.
Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction
Biochem. Biophys. Res. Commun.
358
1128-1135
2007
Strongylocentrotus purpuratus
Hammer, A.; Hodgson, D.R.; Cann, M.J.
Regulation of prokaryotic adenylyl cyclases by CO2
Biochem. J.
396
215-218
2006
Anabaena sp., Synechocystis sp.
Alvarez-Curto, E.; Weening, K.E.; Schaap, P.
Pharmacological profiling of the Dictyostelium adenylate cyclases ACA, ACB and ACG
Biochem. J.
401
309-316
2007
Dictyostelium discoideum
Wang, S.C.; Lai, H.L.; Chiu, Y.T.; Ou, R.; Huang, C.L.; Chern, Y.
Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor
Biochem. J.
406
383-388
2007
Rattus norvegicus (Q04400)
Diel, S.; Beyermann, M.; Navarro Llorens, J.M.; Wittig, B.; Kleuss, C.
Two Interaction Sites on Mammalian Adenylyl Cyclase Type I and II: modulation by calmodulin and Gbetagamma
Biochem. J.
411
449-456
2008
Bos taurus (P19754)
Sayner, S.; Stevens, T.
Soluble adenylate cyclase reveals the significance of compartmentalized cAMP on endothelial cell barrier function
Biochem. Soc. Trans.
34
492-494
2006
synthetic construct
Kolachala, V.L.; Obertone, T.S.; Wang, L.; Merlin, D.; Sitaraman, S.V.
Adenosine 2b receptor (A2bR) signals through adenylate cyclase (AC) 6 isoform in the intestinal epithelial cells
Biochim. Biophys. Acta
1760
1102-1108
2006
Cricetulus griseus, Homo sapiens
Strait, K.A.; Stricklett, P.K.; Kohan, D.E.
Altered collecting duct adenylyl cyclase content in collecting duct endothelin-1 knockout mice
BMC Nephrol.
8
8
2007
Mus musculus
Baudouin-Legros, M.; Hamdaoui, N.; Borot, F.; Fritsch, J.; Ollero, M.; Planelles, G.; Edelman, A.
Control of Basal CFTR Gene Expression by Bicarbonate-Sensitive Adenylyl Cyclase in Human Pulmonary Cells
Cell. Physiol. Biochem.
21
75-86
2008
Homo sapiens
Linder, J.U.
Class III adenylyl cyclases: molecular mechanisms of catalysis and regulation
Cell. Mol. Life Sci.
63
1736-1751
2006
Bacillus anthracis, Bordetella pertussis, Saccharomyces cerevisiae, Caenorhabditis elegans, Chlamydomonas reinhardtii, Chloroflexus aurantiacus, Dictyostelium discoideum, Drosophila melanogaster, Escherichia coli, Euglena gracilis, Mus musculus, Myxococcus xanthus, Pseudomonas aeruginosa, Rattus norvegicus, Sinorhizobium meliloti, Schizosaccharomyces pombe, Arthrospira platensis, Trypanosoma brucei, Ustilago maydis, Yersinia enterocolitica, Mycobacterium tuberculosis (P9WQ35), Nostoc sp. PCC 7120 = FACHB-418 (Q7A2D9), Nostoc sp. PCC 7120 = FACHB-418 (Q8YMH0), Nostoc sp. PCC 7120 = FACHB-418 (Q8YVS0), Mycobacterium tuberculosis H37Rv (P9WQ35)
Gros, R.; Ding, Q.; Chorazyczewski, J.; Pickering, J.G.; Limbird, L.E.; Feldman, R.D.
Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization
Circ. Res.
99
845-852
2006
Rattus norvegicus
Xie, F.; Garcia, M.A.; Carlson, A.E.; Schuh, S.M.; Babcock, D.F.; Jaiswal, B.S.; Gossen, J.A.; Esposito, G.; van Duin, M.; Conti, M.
Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization
Dev. Biol.
296
353-362
2006
Mus musculus
Beazely, M.A.; Watts, V.J.
Regulatory properties of adenylate cyclases type 5 and 6: A progress report
Eur. J. Pharmacol.
535
1-12
2006
Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Abdel Motaal, A.; Tews, I.; Schultz, J.E.; Linder, J.U.
Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv
FEBS J.
273
4219-4228
2006
Mycobacterium tuberculosis (P71914), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P71914), Mycobacterium tuberculosis H37Rv
Linder, J.U.; Bruder, S.; Schultz, A.; Schultz, J.E.
Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2
FEBS J.
274
1514-1523
2007
Anabaena sp. (P94181)
Shenoy, A.R.; Visweswariah, S.S.
Mycobacterial adenylyl cyclases: biochemical diversity and structural plasticity
FEBS Lett.
580
3344-3352
2006
Brevibacterium sp., Mycobacterium avium, Mycobacterium tuberculosis variant bovis, Mycobacterium leprae, Mycobacterium marinum, Mycolicibacterium smegmatis, Streptomyces coelicolor, Mycobacterium tuberculosis (O06362), Mycobacterium tuberculosis (O06572), Mycobacterium tuberculosis (O07732), Mycobacterium tuberculosis (O53213), Mycobacterium tuberculosis (O53720), Mycobacterium tuberculosis (P71914), Mycobacterium tuberculosis (P94982), Mycobacterium tuberculosis (P9WM05), Mycobacterium tuberculosis (P9WMU7), Mycobacterium tuberculosis (P9WMV1), Mycobacterium tuberculosis (P9WQ29), Mycobacterium tuberculosis (P9WQ31), Mycobacterium tuberculosis (P9WQ33), Mycobacterium tuberculosis (P9WQ35), Mycobacterium tuberculosis (Q11028), Mycobacterium avium subsp. paratuberculosis (Q73S12), Mycobacterium avium subsp. paratuberculosis (Q73T75), Mycobacterium avium subsp. paratuberculosis (Q73WG5), Mycobacterium avium subsp. paratuberculosis (Q73WI8), Mycobacterium avium subsp. paratuberculosis (Q73X03), Mycobacterium avium subsp. paratuberculosis (Q73X69), Mycobacterium avium subsp. paratuberculosis (Q73XQ9), Mycobacterium avium subsp. paratuberculosis (Q73Y78), Mycobacterium avium subsp. paratuberculosis (Q740J3), Mycobacterium avium subsp. paratuberculosis (Q740N2), Mycobacterium avium subsp. paratuberculosis (Q740R3), Mycobacterium avium subsp. paratuberculosis (Q744B5), Mycobacterium tuberculosis H37Rv (O53213), Mycobacterium tuberculosis H37Rv (O53720), Mycobacterium tuberculosis H37Rv (P71914), Mycobacterium tuberculosis H37Rv (P94982), Mycobacterium tuberculosis H37Rv (P9WM05), Mycobacterium tuberculosis H37Rv (P9WMU7), Mycobacterium tuberculosis H37Rv (P9WMV1), Mycobacterium tuberculosis H37Rv (P9WQ29), Mycobacterium tuberculosis H37Rv (P9WQ31), Mycobacterium tuberculosis H37Rv (P9WQ33), Mycobacterium tuberculosis H37Rv (P9WQ35), Mycobacterium avium TN104
Nlend, M.C.; Schmid, A.; Sutto, Z.; Ransford, G.A.; Conner, G.E.; Fregien, N.; Salathe, M.
Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia
FEBS Lett.
581
3241-3246
2007
Homo sapiens
Perez Vidakovics, M.L.; Lamberti, Y.; van der Pol, W.L.; Yantorno, O.; Rodriguez, M.E.
Adenylate cyclase influences filamentous haemagglutinin-mediated attachment of Bordetella pertussis to epithelial alveolar cells
FEMS Immunol. Med. Microbiol.
48
140-147
2006
Bordetella pertussis, Bordetella pertussis Tohama I
Ortiz-Capisano, M.C.; Ortiz, P.A.; Harding, P.; Garvin, J.L.; Beierwaltes, W.H.
Decreased intracellular calcium stimulates renin release via calcium-inhibitable adenylyl cyclase
Hypertension
49
162-169
2007
Mus musculus, Mus musculus C57/B6
Ortiz-Capisano, M.C.; Ortiz, P.A.; Harding, P.; Garvin, J.L.; Beierwaltes, W.H.
Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells
Hypertension
49
618-624
2007
Mus musculus, Mus musculus C57/B6
Chapman, K.E.; Duggan, P.S.; Billington, N.A.; Adams, D.G.
Mutation at different sites in the Nostoc punctiforme cyaC gene, encoding the multiple domain enzyme adenylate cyclase, results in different levels of infection of the host plant Blasia pusilla
J. Bacteriol.
190
1843-1847
2007
Nostoc punctiforme
Gao, X.; Sadana, R.; Dessauer, C.W.; Patel, T.B.
Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits
J. Biol. Chem.
282
294-302
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Willoughby, D.; Cooper, D.M.
Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP
J. Cell Sci.
119
828-836
2006
Homo sapiens
Bishop, G.A.; Berbari, N.F.; Lewis, J.; Mykytyn, K.
Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain
J. Comp. Neurol.
505
562-571
2007
Mus musculus, Mus musculus 129:BL6
Schmid, A.; Sutto, Z.; Nlend, M.C.; Horvath, G.; Schmid, N.; Buck, J.; Levin, L.R.; Conner, G.E.; Fregien, N.; Salathe, M.
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP
J. Gen. Physiol.
130
99-109
2007
Homo sapiens
Gallagher, D.T.; Smith, N.N.; Kim, S.K.; Heroux, A.; Robinson, H.; Reddy, P.T.
Structure of the class IV adenylyl cyclase reveals a novel fold
J. Mol. Biol.
362
114-122
2006
Yersinia pestis (Q7CH76), Yersinia pestis
Findeisen, F.; Linder, J.U.; Schultz, A.; Schultz, J.E.; Bruegger, B.; Wieland, F.; Sinning, I.; Tews, I.
The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid
J. Mol. Biol.
369
1282-1295
2007
Mycobacterium tuberculosis (P9WQ35), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ35)
Wachten, S.; Schlenstedt, J.; Gauss, R.; Baumann, A.
Molecular identification and functional characterization of an adenylyl cyclase from the honeybee
J. Neurochem.
96
1580-1590
2006
Apis mellifera (Q1MU16), Apis mellifera
Rottlaender, D.; Matthes, J.; Vatner, S.F.; Seifert, R.; Herzig, S.
Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2(3)-O-(N-methylanthraniloyl)-guanosine 5-[gamma-thio]triphosphate
J. Pharmacol. Exp. Ther.
321
608-615
2007
Mus musculus, Mus musculus C57BL/6
Nawoschik, S.P.; Olsen, M.; Smith, D.L.; Khawaja, X.
Stable expression of adenylyl cyclase 2 leads to the functional rescue of human 5-HT6 receptor in a CHODUKX cell line
J. Pharmacol. Toxicol. Methods
55
323-331
2007
Rattus norvegicus
Mattick, P.; Parrington, J.; Odia, E.; Simpson, A.; Collins, T.; Terrar, D.
Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current
J. Physiol.
582
1195-1203
2007
Cavia porcellus
Watts, V.J.
Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection
Mol. Interv.
7
70-73
2007
Mus musculus, Rattus norvegicus
Mou, T.C.; Gille, A.; Suryanarayana, S.; Richter, M.; Seifert, R.; Sprang, S.R.
Broad specificity of mammalian adenylyl cyclase for interaction with 2,3-substituted purine- and pyrimidine nucleotide inhibitors
Mol. Pharmacol.
70
878-886
2006
Canis lupus familiaris, Rattus norvegicus
Goettle, M.; Dove, S.; Steindel, P.; Shen, Y.; Tang, W.J.; Geduhn, J.; Koenig, B.; Seifert, R.
Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides
Mol. Pharmacol.
72
526-535
2007
Bordetella pertussis
Lastro, M.; Collins, S.; Currie, W.B.
Adenylyl cyclases in oocyte maturation: a characterization of AC isoforms in bovine cumulus cells
Mol. Reprod. Dev.
73
1202-1210
2006
Bos taurus
Antoni, F.A.; Wiegand, U.K.; Black, J.; Simpson, J.
Cellular localisation of adenylyl cyclase: a post-genome perspective
Neurochem. Res.
31
287-295
2006
Homo sapiens, Macaca sp., Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
Conti, A.C.; Maas, J.W.; Muglia, L.M.; Dave, B.A.; Vogt, S.K.; Tran, T.T.; Rayhel, E.J.; Muglia, L.J.
Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain
Neuroscience
146
713-729
2007
Mus musculus, Mus musculus C57BL/6
Willoughby, D.; Cooper, D.M.
Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains
Physiol. Rev.
87
965-1010
2007
Aplysia sp., Canis lupus familiaris, Oryctolagus cuniculus, Dictyostelium discoideum, Drosophila sp. (in: flies), Homo sapiens, Mus musculus, Paramecium sp., Rattus norvegicus, Tetrahymena sp., Plasmodium sp.
Kim, K.S.; Lee, K.W.; Lee, K.W.; Im, J.Y.; Yoo, J.Y.; Kim, S.W.; Lee, J.K.; Nestler, E.J.; Han, P.L.
Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action
Proc. Natl. Acad. Sci. USA
103
3908-3913
2006
Mus musculus, Mus musculus C57/BL6J
Sinha, S.C.; Sprang, S.R.
Structure, mechanism, regulation and evolution of class III nucleotidyl cyclases
Rev. Physiol. Biochem. Pharmacol.
157
105-140
2007
Aeromonas hydrophila, Bacillus anthracis, Prevotella ruminicola, Bordetella pertussis, Canis lupus familiaris, Caulobacter vibrioides, Escherichia sp., Haemophilus sp., Mycobacterium tuberculosis, Yersinia pestis, Pseudomonas sp., Pseudomonas aeruginosa, Rattus norvegicus, Rhizobium etli, Sinorhizobium meliloti, Arthrospira platensis, Trypanosoma brucei, Vibrio parahaemolyticus, Yersinia sp.
Cooper, D.M.; Crossthwaite, A.J.
Higher-order organization and regulation of adenylyl cyclases
Trends Pharmacol. Sci.
27
426-431
2006
Homo sapiens
Li, Y.; Descorbeth, M.; Anand-Srivastava, M.B.
Role of oxidative stress in high glucose-induced decreased expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells
Am. J. Physiol. Heart Circ. Physiol.
294
H2845-H2854
2008
Rattus norvegicus
Spangler, C.M.; Spangler, C.; Goettle, M.; Shen, Y.; Tang, W.J.; Seifert, R.; Schaeferling, M.
A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin
Anal. Biochem.
381
86-93
2008
Bacillus anthracis
Lee, C.B.; Koh, H.C.
Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats
Auton. Neurosci.
146
70-75
2009
Rattus norvegicus
Linder, J.U.
Structure-function relationships in Escherichia coli adenylate cyclase
Biochem. J.
415
449-454
2008
Escherichia coli (P00936), Escherichia coli
Bosier, B.; Hermans, E.; Lambert, D.M.
Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression
Biochem. Pharmacol.
77
216-227
2009
Mus musculus, Mus musculus C57BL/6
Zachariou, V.; Liu, R.; LaPlant, Q.; Xiao, G.; Renthal, W.; Chan, G.C.; Storm, D.R.; Aghajanian, G.; Nestler, E.J.
Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies
Biol. Psychiatry
63
1013-1021
2008
Mus musculus (O88444), Mus musculus (P97490)
Krishnan, V.; Graham, A.; Mazei-Robison, M.S.; Lagace, D.C.; Kim, K.S.; Birnbaum, S.; Eisch, A.J.; Han, P.L.; Storm, D.R.; Zachariou, V.; Nestler, E.J.
Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting
Biol. Psychiatry
64
336-343
2008
Mus musculus (O88444), Mus musculus (P84309), Mus musculus (P97490)
Koukoulitsa, C.; Zervou, M.; Demetzos, C.; Mavromoustakos, T.
Comparative docking studies of labdane-type diterpenes with forskolin at the active site of adenylyl cyclase
Bioorg. Med. Chem.
16
8237-8243
2008
Homo sapiens
Eyler, C.E.; Jackson, T.; Elliott, L.E.; De Castro, L.M.; Jonassaint, J.; Ashley-Koch, A.; Telen, M.J.
beta2-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion
Br. J. Haematol.
141
105-108
2008
Homo sapiens
Slotkin, T.A.; Ryde, I.T.; Mackillop, E.A.; Bodwell, B.E.; Seidler, F.J.
Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects
Brain Res. Bull.
76
522-530
2008
Rattus norvegicus
Wann, B.P.; DAnjou, B.; Bah, T.M.; Webster, H.H.; Godbout, R.; Rousseau, G.
Effect of olfactory bulbectomy on adenylyl cyclase activity in the limbic system
Brain Res. Bull.
79
32-36
2009
Homo sapiens, Rattus norvegicus
Ichikawa, S.; Koller, D.L.; Curry, L.R.; Lai, D.; Xuei, X.; Edenberg, H.J.; Hui, S.L.; Peacock, M.; Foroud, T.; Econs, M.J.
Association of adenylate cyclase 10 (ADCY10) polymorphisms and bone mineral density in healthy adults
Calcif. Tissue Int.
84
97-102
2009
Homo sapiens
Xu, X.L.; Lee, R.T.; Fang, H.M.; Wang, Y.M.; Li, R.; Zou, H.; Zhu, Y.; Wang, Y.
Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p
Cell Host Microbe
4
28-39
2008
Candida albicans
Kloster, M.M.; Hafte, T.T.; Moltzau, L.R.; Naderi, E.H.; Dahle, M.K.; Skalhegg, B.S.; Gaudernack, G.; Levy, F.O.; Naderi, S.; Blomhoff, H.K.
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase
Cell. Signal.
20
1169-1178
2008
Homo sapiens
Baragli, A.; Grieco, M.L.; Trieu, P.; Villeneuve, L.R.; Hebert, T.E.
Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s
Cell. Signal.
20
480-492
2008
Mus musculus (P84309), Mus musculus (Q80TL1), Mus musculus
Thangavel, M.; Liu, X.; Sun, S.Q.; Kaminsky, J.; Ostrom, R.S.
The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae
Cell. Signal.
21
301-308
2009
Homo sapiens
Vatner, S.F.; Yan, L.; Ishikawa, Y.; Vatner, D.E.; Sadoshima, J.
Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress
Circ. J.
73
195-200
2009
Mus musculus
Ueno, K.; Kidokoro, Y.
Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster
Eur. J. Neurosci.
28
1956-1966
2008
Drosophila melanogaster
Ohnishi, H.; Miyake, M.; Kamitani, S.; Horiguchi, Y.
The morphological changes in cultured cells caused by Bordetella pertussis adenylate cyclase toxin
FEMS Microbiol. Lett.
279
174-179
2008
Bordetella pertussis
Kamerewerd, J.; Jansson, M.; Nowrousian, M.; Poeggeler, S.; Kueck, U.
Three alpha-subunits of heterotrimeric G proteins and an adenylyl cyclase have distinct roles in fruiting body development in the homothallic fungus Sordaria macrospora
Genetics
180
191-206
2008
Sordaria macrospora (B3KYI7), Sordaria macrospora
Costa, L.; Santangelo, F.; Li Volsi, G.; Ciranna, L.
Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus
Hippocampus
19
99-109
2009
Rattus norvegicus
Paccani, S.R.; Dal Molin, F.; Benagiano, M.; Ladant, D.; DElios, M.M.; Montecucco, C.; Baldari, C.T.
Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis
Infect. Immun.
76
2822-2832
2008
Bordetella pertussis
Mann, L.; Heldman, E.; Shaltiel, G.; Belmaker, R.H.; Agam, G.
Lithium preferentially inhibits adenylyl cyclase V and VII isoforms
Int. J. Neuropsychopharmacol.
11
533-539
2008
Mus musculus
Lai, N.C.; Tang, T.; Gao, M.H.; Saito, M.; Takahashi, T.; Roth, D.M.; Hammond, H.K.
Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice
J. Am. Coll. Cardiol.
51
1490-1497
2008
Mus musculus
Okumura, S.; Tsunematsu, T.; Bai, Y.; Jiao, Q.; Ono, S.; Suzuki, S.; Kurotani, R.; Sato, M.; Minamisawa, S.; Umemura, S.; Ishikawa, Y.
Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight
J. Appl. Physiol.
105
173-179
2008
Mus musculus (P84309), Mus musculus, Mus musculus C57BL/6 (P84309)
Buboltz, A.M.; Nicholson, T.L.; Parette, M.R.; Hester, S.E.; Parkhill, J.; Harvill, E.T.
Replacement of adenylate cyclase toxin in a lineage of Bordetella bronchiseptica
J. Bacteriol.
190
5502-5511
2008
Bordetella bronchiseptica
Younes, A.; Lyashkov, A.E.; Graham, D.; Sheydina, A.; Volkova, M.V.; Mitsak, M.; Vinogradova, T.M.; Lukyanenko, Y.O.; Li, Y.; Ruknudin, A.M.; Boheler, K.R.; van Eyk, J.; Lakatta, E.G.
Ca2+-stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells
J. Biol. Chem.
283
14461-14468
2008
Oryctolagus cuniculus
Jiang, L.I.; Collins, J.; Davis, R.; Fraser, I.D.; Sternweis, P.C.
Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII
J. Biol. Chem.
283
23429-23439
2008
Homo sapiens (P51828), Homo sapiens (P51829)
Guo, Q.; Jureller, J.E.; Warren, J.T.; Solomaha, E.; Florian, J.; Tang, W.J.
Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently
J. Biol. Chem.
283
23836-23845
2008
Bordetella pertussis (P0DKX7), Bordetella pertussis
Gao, M.H.; Tang, T.; Guo, T.; Miyanohara, A.; Yajima, T.; Pestonjamasp, K.; Feramisco, J.R.; Hammond, H.K.
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes
J. Biol. Chem.
283
33527-33535
2008
Mus musculus, Rattus norvegicus
Hallows, K.R.; Wang, H.; Edinger, R.S.; Butterworth, M.B.; Oyster, N.M.; Li, H.; Buck, J.; Levin, L.R.; Johnson, J.P.; Pastor-Soler, N.M.
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells
J. Biol. Chem.
284
5774-5783
2009
Rattus norvegicus (Q9Z286)
Sakihama, T.; Masuda, K.; Sato, T.; Doi, T.; Kodama, T.; Hamakubo, T.
Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system
J. Biotechnol.
135
28-33
2008
Homo sapiens (O43306)
Tovey, S.C.; Dedos, S.G.; Taylor, E.J.; Church, J.E.; Taylor, C.W.
Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP
J. Cell Biol.
183
297-311
2008
Homo sapiens (O43306), Homo sapiens (O60266), Homo sapiens
Ramos, L.S.; Zippin, J.H.; Kamenetsky, M.; Buck, J.; Levin, L.R.
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells
J. Gen. Physiol.
132
329-338
2008
Rattus norvegicus
Kamanova, J.; Kofronova, O.; Masin, J.; Genth, H.; Vojtova, J.; Linhartova, I.; Benada, O.; Just, I.; Sebo, P.
Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling
J. Immunol.
181
5587-5597
2008
Bordetella sp.
Schlicker, C.; Rauch, A.; Hess, K.C.; Kachholz, B.; Levin, L.R.; Buck, J.; Steegborn, C.
Structure-based development of novel adenylyl cyclase inhibitors
J. Med. Chem.
51
4456-4464
2008
Rattus norvegicus, Arthrospira platensis (O32393), Homo sapiens (Q96PN6), Homo sapiens
Kim, K.S.; Lee, K.W.; Baek, I.S.; Lim, C.M.; Krishnan, V.; Lee, J.K.; Nestler, E.J.; Han, P.L.
Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior
J. Neurochem.
107
105-115
2008
Mus musculus
Jackson, C.R.; Chaurasia, S.S.; Zhou, H.; Haque, R.; Storm, D.R.; Michael Iuvone, P.
Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in photoreceptor cells
J. Neurochem.
109
148-157
2009
Mus musculus, Mus musculus C57/BL6J
Ueda, A.; Wu, C.F.
Role of rut adenylyl cyclase in the ensemble regulation of presynaptic terminal excitability: reduced synaptic strength and precision in a Drosophila memory mutant
J. Neurogenet.
23
185-199
2008
Drosophila melanogaster
Shan, Q.; Chan, G.C.; Storm, D.R.
Type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory
J. Neurosci.
28
12864-12867
2008
Mus musculus
Donati, R.J.; Dwivedi, Y.; Roberts, R.C.; Conley, R.R.; Pandey, G.N.; Rasenick, M.M.
Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase
J. Neurosci.
28
3042-3050
2008
Homo sapiens
Moore, S.W.; Lai Wing Sun, K.; Xie, F.; Barker, P.A.; Conti, M.; Kennedy, T.E.
Soluble adenylyl cyclase is not required for axon guidance to netrin-1
J. Neurosci.
28
3920-3924
2008
Mus musculus (Q8C0T9), Rattus norvegicus (Q9Z286)
Wang, H.; Wu, L.J.; Zhang, F.; Zhuo, M.
Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors
J. Neurosci.
28
4385-4397
2008
Mus musculus (O88444), Mus musculus (P97490)
Zhang, M.; Moon, C.; Chan, G.C.; Yang, L.; Zheng, F.; Conti, A.C.; Muglia, L.; Muglia, L.J.; Storm, D.R.; Wang, H.
Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory
J. Neurosci.
28
4736-4744
2008
Mus musculus, Mus musculus (P97490), Mus musculus C57BL/6, Mus musculus C57BL/6 (P97490)
Moulder, K.L.; Jiang, X.; Chang, C.; Taylor, A.A.; Benz, A.M.; Conti, A.C.; Muglia, L.J.; Mennerick, S.
A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing
J. Neurosci.
28
5159-5168
2008
Mus musculus, Rattus norvegicus
Iwasato, T.; Inan, M.; Kanki, H.; Erzurumlu, R.S.; Itohara, S.; Crair, M.C.
Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development
J. Neurosci.
28
5931-5943
2008
Mus musculus
Brown, J.T.; Kant, A.; Mailman, R.B.
Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: Application in GPCR-mediated adenylate cyclase assays
J. Neurosci. Methods
177
261-266
2009
Homo sapiens
Davis-Taber, R.; Baker, S.; Lehto, S.G.; Zhong, C.; Surowy, C.S.; Faltynek, C.R.; Scott, V.E.; Honore, P.
Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states
J. Pain
9
449-456
2008
Rattus norvegicus
Vonk, A.; Reinart, R.; Rinken, A.
Modulation of adenylyl cyclase activity in rat striatal homogenate by dopaminergic receptors
J. Pharmacol. Sci.
108
63-70
2008
Rattus norvegicus
Gao, J.; Zhang, L.; Wang, Y.; Lu, B.; Cui, H.; Fu, W.; Wang, H.; Yu, Y.; Yu, X.
Antiarrhythmic effect of acupuncture pretreatment in rats subjected to simulative global ischemia and reperfusion - involvement of adenylate cyclase, protein kinase a, and L-type ca(2+) channel
J. Physiol. Sci.
58
389-396
2008
Rattus norvegicus
Lomovatskaya, L.A.; Romanenko, A.S.; Filinova, N.V.
Plant adenylate cyclases
J. Recept. Signal Transduct. Res.
28
531-542
2008
Euglena gracilis, Medicago sativa, Nicotiana tabacum, Solanum tuberosum, Bryum argenteum, Rattus norvegicus (Q9Z286)
Bailey, C.P.; Nicholls, R.E.; Zhang, X.L.; Zhou, Z.Y.; Mueller, W.; Kandel, E.R.; Stanton, P.K.
Galpha(i2) inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses
Learn. Mem.
15
261-270
2008
Mus musculus
Farrell, S.R.; Howlett, S.E.
The age-related decrease in catecholamine sensitivity is mediated by ss(1)-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats
Mech. Ageing Dev.
129
735-744
2008
Rattus norvegicus
Cheung, G.Y.; Kelly, S.M.; Jess, T.J.; Prior, S.; Price, N.C.; Parton, R.; Coote, J.G.
Functional and structural studies on different forms of the adenylate cyclase toxin of Bordetella pertussis
Microb. Pathog.
46
36-42
2009
Bordetella pertussis (P0DKX7), Bordetella pertussis
Clark, M.J.; Linderman, J.J.; Traynor, J.R.
Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model
Mol. Pharmacol.
73
1538-1548
2008
Homo sapiens
Martin, A.C.; Willoughby, D.; Ciruela, A.; Ayling, L.J.; Pagano, M.; Wachten, S.; Tengholm, A.; Cooper, D.M.
Capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8
Mol. Pharmacol.
75
830-842
2009
Mus musculus, Rattus norvegicus (P40146)
Ristori, C.; Ferretti, M.E.; Pavan, B.; Cervellati, F.; Casini, G.; Catalani, E.; Dal Monte, M.; Biondi, C.
Adenylyl cyclase/cAMP system involvement in the antiangiogenic effect of somatostatin in the retina. Results from transgenic mice
Neurochem. Res.
33
1247-1255
2008
Mus musculus
Sanchez, G.; Colettis, N.; Vazquez, P.; Cervenansky, C.; Aguirre, A.; Quillfeldt, J.A.; Jerusalinsky, D.; Kornisiuk, E.
Muscarinic inhibition of hippocampal and striatal adenylyl cyclase is mainly due to the M(4) receptor
Neurochem. Res.
34
1363-1371
2009
Rattus norvegicus
Mostany, R.; Diaz, A.; Valdizan, E.M.; Rodriguez-Munoz, M.; Garzon, J.; Hurle, M.A.
Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits
Neuropharmacology
54
989-997
2008
Rattus norvegicus
Dwivedi, Y.; Pandey, G.N.
Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
Neuropsychiatr. Disease Treat.
4
161-176
2008
Homo sapiens
Sadana, R.; Dessauer, C.W.
Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies
Neurosignals
17
5-22
2009
Mammalia, Mus musculus, Mus musculus (O88444), Mus musculus (P51829), Mus musculus (P84309), Mus musculus (P97490), Mus musculus (Q01341), Mus musculus (Q80TL1), Mus musculus (Q8VHH7)
Farrell, J.; Ramos, L.; Tresguerres, M.; Kamenetsky, M.; Levin, L.R.; Buck, J.
Somatic soluble adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex knockout mice
PLoS ONE
3
e3251
2008
Rattus norvegicus
Ono, T.; Cabrita-Santos, L.; Leitao, R.; Bettiol, E.; Purcell, L.A.; Diaz-Pulido, O.; Andrews, L.B.; Tadakuma, T.; Bhanot, P.; Mota, M.M.; Rodriguez, A.
Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection
PLoS Pathog.
4
e1000008
2008
Plasmodium berghei, Plasmodium falciparum, Plasmodium yoelii
Piggott, L.A.; Bauman, A.L.; Scott, J.D.; Dessauer, C.W.
The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain
Proc. Natl. Acad. Sci. USA
105
13835-13840
2008
Rattus norvegicus
Ryzhov, S.; Zaynagetdinov, R.; Goldstein, A.E.; Matafonov, A.; Biaggioni, I.; Feoktistov, I.
Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8
Purinergic Signal.
5
289-298
2009
Cricetulus griseus, Homo sapiens
Rhim, J.H.; Jang, I.S.; Song, K.Y.; Ha, M.K.; Cho, S.C.; Yeo, E.J.; Park, S.C.
Lysophosphatidic acid and adenylyl cyclase inhibitor increase proliferation of senescent human diploid fibroblasts by inhibiting adenosine monophosphate-activated protein kinase
Rejuvenation Res.
11
781-792
2008
Homo sapiens
Marquez, B.; Suarez, S.S.
Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation
Reprod. Fertil. Dev.
20
247-252
2008
Mus musculus (Q8C0T9)
von Hayn, K.; Werthmann, R.C.; Nikolaev, V.O.; Hommers, L.G.; Lohse, M.J.; Buenemann, M.
Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells
Am. J. Physiol. Cell Physiol.
298
C324-C332
2010
Mus musculus
Strait, K.A.; Stricklett, P.K.; Chapman, M.; Kohan, D.E.
Characterization of vasopressin-responsive collecting duct adenylyl cyclases in the mouse
Am. J. Physiol. Renal Physiol.
298
F859-F867
2010
Mus musculus
Cha, P.H.; Park, S.Y.; Park, S.Y.; Moon, M.W.; Subhadra, B.; Oh, T.K.; Kim, E.; Kim, J.F.; Lee, J.K.
Characterization of an adenylate cyclase gene (cyaB) deletion mutant of Corynebacterium glutamicum ATCC 13032
Appl. Microbiol. Biotechnol.
85
1061-1068
2010
Corynebacterium glutamicum
Koshimizu, T.A.; Tsuchiya, H.; Tsuda, H.; Fujiwara, Y.; Shibata, K.; Hirasawa, A.; Tsujimoto, G.; Fujimura, A.
Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment
Biochem. Biophys. Res. Commun.
392
603-607
2010
Homo sapiens
Mou, T.C.; Masada, N.; Cooper, D.M.; Sprang, S.R.
Structural basis for inhibition of mammalian adenylyl cyclase by calcium
Biochemistry
48
3387-3397
2009
Homo sapiens
Bennun, A.
Characterization of the norepinephrine-activation of adenylate cyclase suggests a role in memory affirmation pathways Overexposure to epinephrine inactivates adenylate cyclase, a causal pathway for stress-pathologies
BioSystems
100
87-93
2010
Rattus norvegicus
Mann, L.; Heldman, E.; Bersudsky, Y.; Vatner, S.F.; Ishikawa, Y.; Almog, O.; Belmaker, R.H.; Agam, G.
Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect
Bipolar. Disord.
11
885-896
2009
Mus musculus
Liou, J.T.; Liu, F.C.; Mao, C.C.; Hsin, S.T.; Lui, P.W.
Adenylate cyclase inhibition attenuates neuropathic pain but lacks pre-emptive effects in rats
Can. J. Anesth.
56
763-769
2009
Rattus norvegicus
Oener, S.S.; Kaya, A.I.; Onaran, H.O.; Oezcan, G.; Ugur, O.
beta2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low density membrane fractions
Eur. J. Pharmacol.
630
42-52
2010
Homo sapiens
Guo, Y.L.; Mayer, H.; Vollmer, W.; Dittrich, D.; Sander, P.; Schultz, A.; Schultz, J.E.
Polyphosphates from Mycobacterium bovis--potent inhibitors of class III adenylate cyclases
FEBS J.
276
1094-1103
2009
Mycobacterium tuberculosis, Mycobacterium tuberculosis BCG 1721
Moen, S.T.; Blumentritt, C.A.; Slater, T.M.; Patel, S.D.; Tutt, C.B.; Estrella-Jimenez, M.E.; Pawlik, J.; Sower, L.; Popov, V.L.; Schein, C.H.; Gilbertson, S.R.; Peterson, J.W.; Torres, A.G.
Testing the efficacy and toxicity of adenylyl cyclase inhibitors against enteric pathogens using in vitro and in vivo models of infection
Infect. Immun.
78
1740-1749
2010
Escherichia coli
Macdougall, D.A.; Wachten, S.; Ciruela, A.; Sinz, A.; Cooper, D.M.
Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart Ca2+/calmodulin binding and autoinhibition
J. Biol. Chem.
284
15573-15588
2009
Homo sapiens
Sotomayor Perez, A.C.; Karst, J.C.; Davi, M.; Guijarro, J.I.; Ladant, D.; Chenal, A.
Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the Bordetella pertussis adenylate cyclase toxin
J. Mol. Biol.
397
534-549
2010
Bordetella pertussis
Goettle, M.; Geduhn, J.; Koenig, B.; Gille, A.; Hoecherl, K.; Seifert, R.
Characterization of mouse heart adenylyl cyclase
J. Pharmacol. Exp. Ther.
329
1156-1165
2009
Mus musculus
Suryanarayana, S.; Goettle, M.; Huebner, M.; Gille, A.; Mou, T.C.; Sprang, S.R.; Richter, M.; Seifert, R.
Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2,3-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5-triphosphates
J. Pharmacol. Exp. Ther.
330
687-695
2009
Homo sapiens
Werthmann, R.C.; von Hayn, K.; Nikolaev, V.O.; Lohse, M.J.; Buenemann, M.
Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6
J. Physiol.
587
4091-4104
2009
Homo sapiens
Latini, S.; Chiarpotto, M.; Muciaccia, B.; Vaccari, S.; Barberi, M.; Guglielmo, M.C.; Stefanini, M.; Cecconi, S.; Canipari, R.
Inhibitory effect of pituitary adenylate cyclase activating polypeptide on the initial stages of rat follicle development
Mol. Cell. Endocrinol.
320
34-44
2010
Rattus norvegicus
Mato, S.; Vidal, R.; Castro, E.; Diaz, A.; Pazos, A.; Valdizan, E.M.
Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibition of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms
Mol. Pharmacol.
77
424-434
2010
Rattus norvegicus
Tupal, S.; Faingold, C.
Inhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats
Neuropharmacology
59
107-111
2010
Rattus norvegicus
Jolivel, V.; Basille, M.; Aubert, N.; de Jouffrey, S.; Ancian, P.; Le Bigot, J.F.; Noack, P.; Massonneau, M.; Fournier, A.; Vaudry, H.; Gonzalez, B.J.; Vaudry, D.
Distribution and functional characterization of pituitary adenylate cyclase-activating polypeptide receptors in the brain of non-human primates
Neuroscience
160
434-451
2009
Callithrix jacchus, Macaca fascicularis
Rotte, C.; Krach, C.; Balfanz, S.; Baumann, A.; Walz, B.; Blenau, W.
Molecular characterization and localization of the first tyramine receptor of the American cockroach (Periplaneta americana)
Neuroscience
162
1120-1133
2009
Periplaneta americana
Taylor, M.; Grundt, P.; Griffin, S.A.; Newman, A.H.; Luedtke, R.R.
Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways
Synapse
64
251-266
2010
Homo sapiens
Hasanuzzaman, M.; Yoshimura, M.
Effects of straight chain alcohols on specific isoforms of adenylyl cyclase
Alcohol. Clin. Exp. Res.
34
743-749
2010
Homo sapiens
Blount, M.
A timely characterization of vasopressin-sensitive adenylyl cyclase isoforms in the mouse inner medullary collecting duct
Am. J. Physiol.
298
F857-F858
2010
Mus musculus
Sugano, Y.; Lai, N.C.; Gao, M.H.; Firth, A.L.; Yuan, J.X.; Lew, W.Y.; Hammond, H.K.
Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart
Biochem. Biophys. Res. Commun.
405
349-355
2011
Mus musculus
Derkach, K.; Shpakov, A.; Uspenskaya, Z.; Yudin, A.
Functional characteristics of calcium-sensitive adenylyl cyclase of the infusorian Tetrahymena pyriformis
Cell Tissue Biol.
4
587-593
2010
Tetrahymena pyriformis
-
O'Brien, E.D.; Krapf, D.; Cabada, M.O.; Visconti, P.E.; Arranz, S.E.
Transmembrane adenylyl cyclase regulates amphibian sperm motility through protein kinase A activation
Dev. Biol.
350
80-88
2011
Rhinella arenarum
Fuss, N.; Mujagic, S.; Erber, J.; Wachten, S.; Baumann, A.
Biochemical properties of heterologously expressed and native adenylyl cyclases from the honeybee brain (Apis mellifera L.)
Insect Biochem. Mol. Biol.
40
573-580
2010
Apis mellifera
Stierl, M.; Stumpf, P.; Udwari, D.; Gueta, R.; Hagedorn, R.; Losi, A.; Gaertner, W.; Petereit, L.; Efetova, M.; Schwarzel, M.; Oertner, T.G.; Nagel, G.; Hegemann, P.
Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa
J. Biol. Chem.
286
1181-1188
2011
Beggiatoa sp.
Gallagher, D.T.; Kim, S.K.; Robinson, H.; Reddy, P.T.
Active-site structure of class IV adenylyl cyclase and transphyletic mechanism
J. Mol. Biol.
405
787-803
2011
Yersinia pestis (Q7CH76), Yersinia pestis
Geduhn, J.; Dove, S.; Shen, Y.; Tang, W.J.; Koenig, B.; Seifert, R.
Bis-halogen-anthraniloyl-substituted nucleoside 5-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin
J. Pharmacol. Exp. Ther.
336
104-115
2011
Bordetella pertussis
Fulcher, N.B.; Holliday, P.M.; Klem, E.; Cann, M.J.; Wolfgang, M.C.
The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity
Mol. Microbiol.
76
889-904
2010
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAK
Gao, M.H.; Tang, T.; Lai, N.C.; Miyanohara, A.; Guo, T.; Tang, R.; Firth, A.L.; Yuan, J.X.; Hammond, H.K.
Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant
Mol. Pharmacol.
79
381-388
2011
Rattus norvegicus
Erdorf, M.; Seifert, R.
Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes
Naunyn Schmiedebergs Arch. Pharmacol.
383
357-372
2011
Oryctolagus cuniculus
Pinto, C.; Lushington, G.H.; Richter, M.; Gille, A.; Geduhn, J.; Koenig, B.; Mou, T.C.; Sprang, S.R.; Seifert, R.
Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases
Biochem. Pharmacol.
82
358-370
2011
Homo sapiens
Imber, A.N.; Santin, J.M.; Graham, C.D.; Putnam, R.W.
A HCO3--dependent mechanism involving soluble adenylyl cyclase for the activation of Ca2+ currents in locus coeruleus neurons
Biochim. Biophys. Acta
1842
2569-2578
2014
Rattus norvegicus
Heindorff, K.; Blenau, W.; Walz, B.; Baumann, O.
Characterization of a Ca2+/calmodulin-dependent AC1 adenylyl cyclase in a non-neuronal tissue, the blowfly salivary gland
Cell Calcium
52
103-112
2012
Calliphora vicina
Balfanz, S.; Ehling, P.; Wachten, S.; Jordan, N.; Erber, J.; Mujagic, S.; Baumann, A.
Functional characterization of transmembrane adenylyl cyclases from the honeybee brain
Insect Biochem. Mol. Biol.
42
435-445
2012
Apis mellifera (I4EC00), Apis mellifera (I4EC01)
Selwa, E.; Davi, M.; Chenal, A.; Sotomayor-Perez, A.C.; Ladant, D.; Malliavin, T.E.
Allosteric activation of Bordetella pertussis adenylyl cyclase by calmodulin: molecular dynamics and mutagenesis studies
J. Biol. Chem.
289
21131-21141
2014
Bordetella pertussis
Nikolic, I.; Mitrovic, M.; Zelen, I.; Zaric, M.; Kastratovic, T.; Stanojevic, M.; Nenadovic, M.; Stojanovic, T.
Inhibitory role of monovalent ions on rat brain cortex adenylyl cyclase activity
J. Enzyme Inhib. Med. Chem.
28
1061-1066
2013
Rattus norvegicus
Topal, H.; Fulcher, N.B.; Bitterman, J.; Salazar, E.; Buck, J.; Levin, L.R.; Cann, M.J.; Wolfgang, M.C.; Steegborn, C.
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa
J. Mol. Biol.
416
271-286
2012
Pseudomonas aeruginosa (Q9HZ23), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (Q9HZ23)
Salazar, E.; Bank, E.M.; Ramsey, N.; Hess, K.C.; Deitsch, K.W.; Levin, L.R.; Buck, J.
Characterization of Plasmodium falciparum adenylyl cyclase-beta and its role in erythrocytic stage parasites
PLoS ONE
7
e39769
2012
Plasmodium falciparum
Kleinboelting, S.; Diaz, A.; Moniot, S.; van den Heuvel, J.; Weyand, M.; Levin, L.R.; Buck, J.; Steegborn, C.
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate
Proc. Natl. Acad. Sci. USA
111
3727-3732
2014
Homo sapiens
Barott, K.L.; Helman, Y.; Haramaty, L.; Barron, M.E.; Hess, K.C.; Buck, J.; Levin, L.R.; Tresguerres, M.
High adenylyl cyclase activity and in vivo cAMP fluctuations in corals suggest central physiological role
Sci. Rep.
3
1379
2013
Pocillopora damicornis, Acropora digitifera
Zhao, Z.; Babu, G.; Wen, H.; Fefelova, N.; Gordan, R.; Sui, X.; Yan, L.; Vatner, D.; Vatner, S.; Xie, L.
Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart
Am. J. Physiol.
308
H240-H249
2015
Mus musculus (P84309)
Fernandez, S.; Cordoba, M.
A membrane-associated adenylate cyclase modulates lactate dehydrogenase and creatine kinase activities required for bull sperm capacitation induced by hyaluronic acid
Anim. Reprod. Sci.
179
80-87
2017
Bos taurus
Luebker, C.; Urbauer, R.; Moskovitz, J.; Dove, S.; Weisemann, J.; Fedorova, M.; Urbauer, J.; Seifert, R.
Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin
Biochem. Pharmacol.
93
196-209
2015
Bos taurus (P19754)
Kleinboelting, S.; Ramos-Espiritu, L.; Buck, H.; Colis, L.; van den Heuvel, J.; Glickman, J.F.; Levin, L.R.; Buck, J.; Steegborn, C.
Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric activator site
J. Biol. Chem.
291
9776-9784
2016
Homo sapiens (Q96PN6), Homo sapiens
Etzl, S.; Lindner, R.; Nelson, M.D.; Winkler, A.
Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic applications
J. Biol. Chem.
293
9078-9089
2018
Synechocystis sp. PCC 6803 (A0A068MZJ9)
Lindner, R.; Hartmann, E.; Tarnawski, M.; Winkler, A.; Frey, D.; Reinstein, J.; Meinhart, A.; Schlichting, I.
Photoactivation mechanism of a bacterial light-regulated adenylyl cyclase
J. Mol. Biol.
429
1336-1351
2017
Beggiatoa sp. PS (A7BT71)
Penzkofer, A.; Tanwar, M.; Veetil, S.; Kateriya, S.
Photo-dynamics of photoactivated adenylyl cyclase TpPAC from the spirochete bacterium Turneriella parva strain HT
J. Photochem. Photobiol. B
153
90-102
2015
Turneriella parva, Turneriella parva DSM 21527
Ritt, M.; Sivaramakrishnan, S.
Correlation between activity and domain complementation in adenylyl cyclase demonstrated with a novel fluorescence resonance energy transfer sensor
Mol. Pharmacol.
89
407-412
2016
Homo sapiens (O95622), Homo sapiens (Q08462)
Scheib, U.; Broser, M.; Constantin, O.M.; Yang, S.; Gao, S.; Mukherjee, S.; Stehfest, K.; Nagel, G.; Gee, C.E.; Hegemann, P5
Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 A structure of the adenylyl cyclase domain
Nat. Commun.
9
2046
2018
Catenaria anguillulae (A0A1Y2HEJ3), Catenaria anguillulae, Catenaria anguillulae PL171 (A0A1Y2HEJ3)
Ohki, M.; Sugiyama, K.; Kawai, F.; Tanaka, H.; Nihei, Y.; Unzai, S.; Takebe, M.; Matsunaga, S.; Adachi, S.; Shibayama, N.; Zhou, Z.; Koyama, R.; Ikegaya, Y.; Takahashi, T.; Tame, J.R.; Iseki, M.; Park, S.Y.
Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium
Proc. Natl. Acad. Sci. USA
113
6659-6664
2016
Oscillatoria acuminata (K9TLZ5), Oscillatoria acuminata, Oscillatoria acuminata PCC 6304 (K9TLZ5)
Ohki, M.; Sato-Tomita, A.; Matsunaga, S.; Iseki, M.; Tame, J.R.H.; Shibayama, N.; Park, S.Y.
Molecular mechanism of photoactivation of a light-regulated adenylate cyclase
Proc. Natl. Acad. Sci. USA
114
8562-8567
2017
Oscillatoria acuminata (K9TLZ5), Oscillatoria acuminata, Oscillatoria acuminata PCC 6304 (K9TLZ5)
Tong, R.; Wade, R.; Bruce, N.
Comparative electrostatic analysis of adenylyl cyclase for isoform dependent regulation properties
Proteins
84
1844-1858
2016
Mus musculus (O88444), Mus musculus (P51829), Mus musculus (P51830), Mus musculus (P84309), Mus musculus (P97490), Mus musculus (Q01341), Mus musculus (Q80TL1), Mus musculus (Q8VHH7), Mus musculus (Q91WF3)
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