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Literature summary for 4.6.1.1 extracted from

  • Ortiz-Capisano, M.C.; Ortiz, P.A.; Harding, P.; Garvin, J.L.; Beierwaltes, W.H.
    Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells (2007), Hypertension, 49, 618-624.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acid cytosolic calcium chelator, reduces isolated juxtaglomerular intracellular calcium, allowing an increased activity of the calcium-inhibitable isoform adenylyl cyclase-V, stimulates both cAMP and renin release Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
Mus musculus
NKY80 selective adenylyl cyclase-V inhibitor, completely blocks both 5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acid–stimulated cAMP formation and renin release Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm AC-V isoform dispersed throughout the cytoplasm in granule like foci, similar cytoplasmic localization for both renin and AC-V Mus musculus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
adenylyl cyclase-V, Western blotting Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C-57/B6 mice
-
Mus musculus C57/B6
-
C-57/B6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information predominance if not the exclusive presence of AC-V isoform in juxtaglomerular cells, AC-VI isoform not detectable Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mus musculus 3',5'-cAMP + diphosphate
-
?
ATP
-
Mus musculus C57/B6 3',5'-cAMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
AC-V
-
Mus musculus
AC-VI
-
Mus musculus
adenylyl cyclase, type-V
-
Mus musculus
adenylyl cyclase, type-VI
-
Mus musculus
adenylyl cyclase-V
-
Mus musculus