Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acid | cytosolic calcium chelator, reduces isolated juxtaglomerular intracellular calcium, allowing an increased activity of the calcium-inhibitable isoform adenylyl cyclase-V, stimulates both cAMP and renin release | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus | |
NKY80 | selective adenylyl cyclase-V inhibitor, completely blocks both 5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acidstimulated cAMP formation and renin release | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | AC-V isoform dispersed throughout the cytoplasm in granule like foci, similar cytoplasmic localization for both renin and AC-V | Mus musculus | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
120000 | - |
adenylyl cyclase-V, Western blotting | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C-57/B6 mice | - |
Mus musculus C57/B6 | - |
C-57/B6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | predominance if not the exclusive presence of AC-V isoform in juxtaglomerular cells, AC-VI isoform not detectable | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Mus musculus C57/B6 | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC-V | - |
Mus musculus |
AC-VI | - |
Mus musculus |
adenylyl cyclase, type-V | - |
Mus musculus |
adenylyl cyclase, type-VI | - |
Mus musculus |
adenylyl cyclase-V | - |
Mus musculus |