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Literature summary for 4.6.1.1 extracted from

  • Ramos, L.S.; Zippin, J.H.; Kamenetsky, M.; Buck, J.; Levin, L.R.
    Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells (2008), J. Gen. Physiol., 132, 329-338.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
G-protein
-
 Rattus norvegicus
glucagon-like peptide-1 stimulates the enzyme via activation of the specific G protein-coupled receptor GLP-1 Rattus norvegicus
glucose
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus the soluble adenylyl cyclase is the main producer of glucose-induced cAMP in INS-1E insulinoma cells, while the transmembrane adenylyl cyclase does not play a role, overview 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
INS-1E cell
-
 Rattus norvegicus
-
insulinoma cell
-
 Rattus norvegicus
-
pancreatic beta cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the soluble adenylyl cyclase is the main producer of glucose-induced cAMP in INS-1E insulinoma cells, while the transmembrane adenylyl cyclase does not play a role, overview Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus