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Literature summary for 4.6.1.1 extracted from

  • Gao, M.H.; Tang, T.; Lai, N.C.; Miyanohara, A.; Guo, T.; Tang, R.; Firth, A.L.; Yuan, J.X.; Hammond, H.K.
    Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant (2011), Mol. Pharmacol., 79, 381-388.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
D425A catalytically inactive mutant of isoform AC6, the expression of the mutant is associated with marked reduction in cAMP production Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC6 isoform Rattus norvegicus
adenylyl cyclase type 6
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
Calmodulin
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus isoform AC6 expression is stimulated by forskolin and isoproterenol (0.01 mM) up