Information on EC 4.6.1.1 - adenylate cyclase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
4.6.1.1
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RECOMMENDED NAME
GeneOntology No.
adenylate cyclase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP = 3',5'-cyclic AMP + diphosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
P-O bond cleavage
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
purine metabolism
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Purine metabolism
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SYSTEMATIC NAME
IUBMB Comments
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-42-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Arthrobacter nicotianae
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Manually annotated by BRENDA team
Beggiatoa sp.
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Manually annotated by BRENDA team
silkworm
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Manually annotated by BRENDA team
strain RB50, no expression in strain 253, gene cyaA
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Manually annotated by BRENDA team
strain Tohama I
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Manually annotated by BRENDA team
gene cyaA
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain SC5314
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain ATCC 13032
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Escherichia sp.
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
turkey
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Mus musculus 129:BL6
129:BL6 background
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Manually annotated by BRENDA team
Mus musculus C-57/B6
C-57/B6 mice
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Manually annotated by BRENDA team
strain BCG 1721
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
no activity in Bacteroides fragilis
crude cell extract
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Manually annotated by BRENDA team
Nocardia erythropolis
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
several forms of the soluble isozyme, and a transmembrane isozyme
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Manually annotated by BRENDA team
a self-fertile filamentous ascomycete, several strains, overview, gene sac1
UniProt
Manually annotated by BRENDA team
squirrel
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
synthetic construct
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Manually annotated by BRENDA team
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Genbank
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
adenyloimidodiphosphate
?
show the reaction diagram
Arthrobacter nicotianae
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?
adenylomethyloendiphosphate
?
show the reaction diagram
Arthrobacter nicotianae
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?
ATP
3',5'-cAMP + diphosphate
show the reaction diagram
ATP
3',5'-cyclic AMP + diphosphate
show the reaction diagram
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
ATP
cAMP + diphosphate
show the reaction diagram
dATP
deoxy-cAMP + diphosphate
show the reaction diagram
Arthrobacter nicotianae
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?
deoxy-cAMP + diphosphate
ATP
show the reaction diagram
Arthrobacter nicotianae
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r
GTP
3',5'-cGMP + diphosphate
show the reaction diagram
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?
GTP
3',5'-cyclic-GMP + diphosphate
show the reaction diagram
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class IV adenylyl cyclase also functions as guanylyl cyclase with about 20% efficiency
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?
GTP
?
show the reaction diagram
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Rv1900
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?
GTP
c-diGMP
show the reaction diagram
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?
MgATP2-
?
show the reaction diagram
MnATP2-
?
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP
3',5'-cAMP + diphosphate
show the reaction diagram
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?
ATP
3',5'-cyclic AMP + diphosphate
show the reaction diagram
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
MgATP2-
?
show the reaction diagram
MnATP2-
?
show the reaction diagram
additional information
?
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