Literature summary for 4.6.1.1 extracted from

Etzl, S.; Lindner, R.; Nelson, M.D.; Winkler, A.
Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic applications (2018), J. Biol. Chem., 293, 9078-9089 .

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Application

Application	Comment	Organism
additional information	construction of a fusion between Deinococcus radiodurans bacteriophytochrome linked to Synechocystis sp. guanylate/adenylate cyclase. The construct shows low dark-state activity and high dynamic range that outperforms previous optogenetic tools in vitro	Synechocystis sp. PCC 6803

Crystallization (Commentary)

Crystallization (Comment)	Organism
fusion between Deinococcus radiodurans bacteriophytochrome linked to Synechocystis sp. guanylate/adenylate cyclase, to 2.35 A resolution. Light-induced conformational changes in the phytochrome destabilize the coiled-coil sensor-effector linker, which releases the cyclase regulatory element from an inhibited conformation, increasing cyclase activity of the artificial system	Synechocystis sp. PCC 6803

Organism

Organism	UniProt	Comment	Textmining
Synechocystis sp. PCC 6803	A0A068MZJ9	-	-

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Release 2023.1 (January 2023)