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Literature summary for 4.6.1.1 extracted from

  • Bailey, C.P.; Nicholls, R.E.; Zhang, X.L.; Zhou, Z.Y.; Mueller, W.; Kandel, E.R.; Stanton, P.K.
    Galpha(i2) inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses (2008), Learn. Mem., 15, 261-270.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Protein Variants

Protein Variants Comment Organism
additional information transgenic mice that express a mutant, constitutively active inhibitory G protein, Galpha12, in principal neurons of the forebrain, show markedly enhanced long-term depression and impaired late-phase long-term potentiation at Schaffer collateral synapses, with no associated differences in input/output relations, paired-pulse facilitation, or NMDA receptor-gated conductances Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Gi GTP-binding protein inhibitory G-protein signaling acts presynaptically to regulate release, and, when paired with elevations in the concentration of cyclic GMP, converts a transient cyclic GMP-induced depression into a long-lasting decrease in release, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
synapse Schaffer collateral-CA1 hippocampal synapses Mus musculus 45202
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus cyclic AMP signaling plays a central role in regulating activity at a number of synapses in the brain, Galpha(i2) inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses, detailed overview 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP cyclic AMP signaling plays a central role in regulating activity at a number of synapses in the brain, Galpha(i2) inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses, detailed overview Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?