Literature summary for 4.6.1.1 extracted from

Farrell, S.R.; Howlett, S.E.
The age-related decrease in catecholamine sensitivity is mediated by ss(1)-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats (2008), Mech. Ageing Dev., 129, 735-744.

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Activating Compound

Activating Compound	Comment	Organism	Structure
forskolin	direct adenylate cyclase agonist, causes smaller increases in contraction and Ca2+ transient amplitudes in aged compared to younger ventricular myocytes	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Fischer 344 rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
myocyte	ventricular, significantly less cAMP formation in response to adenylate cyclase stimulation in aged compared to younger cells	Rattus norvegicus	-

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Release 2023.1 (January 2023)